Chronic closed-angle glaucoma

Summary

Chronic closed-angle glaucoma (MONDO:0001966) is a disease and 4 clinical trials. A subtype of primary angle-closure glaucoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	chronic closed-angle glaucoma
Mondo ID	MONDO:0001966
DOID	DOID:14445
ICD-10-CM	H40.22
SNOMED CT	33647009
UMLS	C0154947
MedGen	509736
Is cancer (heuristic)	no

Also known as: anatomical narrow angle glaucoma · angle-closure glaucoma, chronic · chronic angle-closure glaucoma

Disease family

This is a subtype of primary angle-closure glaucoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › glaucoma › angle-closure glaucoma › primary angle-closure glaucoma › chronic closed-angle glaucoma

Related subtypes (4): interval angle-closure glaucoma, acute closed-angle glaucoma, residual stage angle-closure glaucoma, hereditary glaucoma, primary closed-angle

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02152774	PHASE2	UNKNOWN	A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma
NCT01742819	Not specified	ACTIVE_NOT_RECRUITING	Advanced Glaucoma Progression Study
NCT00452998	Not specified	COMPLETED	Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study
NCT00823706	Not specified	UNKNOWN	Prevalence of Angle Closure in Caucasian Hyperopes