Chronic dacryocystitis

Summary

Chronic dacryocystitis (MONDO:0004925) is a disease and 3 clinical trials. Top therapeutic interventions include fluorouracil and poliglusam. A subtype of chronic inflammation of lacrimal passage — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	chronic dacryocystitis
Mondo ID	MONDO:0004925
DOID	DOID:9937
ICD-10-CM	H04.41
ICD-11	617640909
SNOMED CT	84627005
UMLS	C0149506
MedGen	508388
Is cancer (heuristic)	no

Also known as: dacryocystitis, chronic

Disease family

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye adnexa disorder › lacrimal apparatus disorder › chronic inflammation of lacrimal passage › chronic dacryocystitis

Related subtypes (2): chronic canaliculitis, dacryocystocele

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	1
PHASE1	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07499791	PHASE2	NOT_YET_RECRUITING	Absorbable Drug-Eluting Lacrimal Sac Stent for Recurrent Chronic Dacryocystitis
NCT06175676	PHASE1	COMPLETED	Safety and Efficacy of Thermosensitive Hydroxybutyl Chitosan and 5-fluorouracil Assisted Endoscopic Dacryocystorhinostomy in the Treatment of Chronic Dacryocystitis
NCT06551766	Not specified	RECRUITING	The Application of Photosensitive Hydrogel in Intranasal Endoscopic Dacryocystorhinostomy

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
FLUOROURACIL	4	1
POLIGLUSAM	3	1