Chronic gastritis
diseaseOn this page
Also known as chronic gastritis (disease)gastritis (disease), chronic
Summary
Chronic gastritis (MONDO:0005001) is a disease and 31 clinical trials. Top therapeutic interventions include berberine, esomeprazole, and clarithromycin. A subtype of gastritis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 31
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | chronic gastritis |
| Mondo ID | MONDO:0005001 |
| EFO | EFO:0000337 |
| NCIT | C26929 |
| SNOMED CT | 8493009 |
| UMLS | C0085695 |
| MedGen | 39089 |
| Is cancer (heuristic) | no |
Also known as: chronic gastritis · chronic gastritis (disease) · gastritis (disease), chronic
Data availability: 1 HPO phenotype.
Disease family
This is a subtype of gastritis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › stomach disorder › gastritis › chronic gastritis
Related subtypes (15): gastroduodenal Crohn disease, viral gastritis, eosinophilic gastritis, bacterial gastritis, fungal gastritis, lymphocytic gastritis, necrotizing gastritis, granulomatous gastritis, gastroduodenitis, alcoholic gastritis, gastric mucosal hypertrophy, chronic erosive gastritis, autoimmune gastritis, collagenous gastritis, pediatric collagenous gastritis
Subtypes (1): chronic atrophic gastritis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 4 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Abeprazan | Phase 3 (in late-stage trials) |
| Esomeprazole | Phase 3 (in late-stage trials) |
| Rebamipide | Phase 3 (in late-stage trials) |
| Recoflavone | Phase 3 (in late-stage trials) |
Clinical trials & evidence
Clinical trials
Clinical trials: 31.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE3 | 11 |
| PHASE4 | 9 |
| Not specified | 9 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01119768 | PHASE4 | COMPLETED | Esomeprazole Treatment Co-diagnosed Non Erosive Reflux Disease (NERD) and Chronic Gastritis Patients |
| NCT01817556 | PHASE4 | COMPLETED | A Study to Evaluate the Efficacy and of Stillen Tab. and to Demonstrate the Non-inferiority of Stillen Tab. |
| NCT02356679 | PHASE4 | COMPLETED | Efficacy and Safety of Eupasidin-s Tab.(EUPASIDIN-S) in Gastritis Patients |
| NCT03609892 | PHASE4 | COMPLETED | Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy |
| NCT04697186 | PHASE4 | COMPLETED | Helicobacter Pylori Eradication With Berberine Plus Amoxicillin Triple Therapy Versus Bismuth-containing Quadruple Therapy |
| NCT05014334 | PHASE4 | COMPLETED | Study on The Efficacy and Safety of Berberine-containing Triple Therapy in Helicobacter Pylori First-Line Eradication |
| NCT06514274 | PHASE4 | COMPLETED | Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication |
| NCT06603688 | PHASE4 | UNKNOWN | Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori. |
| NCT07312721 | PHASE4 | COMPLETED | Comparative Effectiveness of Triple Versus Quadruple Therapy in the Treatment of Helicobacter Pylori Induced Gastritis |
| NCT00455806 | PHASE3 | UNKNOWN | Esomeprazole, Moxifloxacin and Amoxicilin for Rescue Therapy of Helicobacter Pylori Infection |
| NCT00996788 | PHASE3 | COMPLETED | Anti Free Radical & Anti Inflammatory Effect & Safety of Rebamipide in Chronic Gastritis |
| NCT01813812 | PHASE3 | UNKNOWN | A Study to Evaluate the Efficacy and Safety of DA-6034 and to Demonstrate the Non-inferiority of DA-6034 |
| NCT02219529 | PHASE3 | COMPLETED | Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases |
| NCT02282670 | PHASE3 | UNKNOWN | A Study to Evaluate the Efficacy and Safety of DA-5204 |
| NCT03443804 | PHASE3 | COMPLETED | To Evaluate the Efficacy and Safety of DW-1401 in Acute and Chronic Gastritis Patients |
| NCT04066530 | PHASE3 | COMPLETED | A Study to Evaluate the Efficacy and Safety of AD-203 |
| NCT04189705 | PHASE3 | COMPLETED | A Study to Evaluate the Efficacy and Safety of MCT-SR in Patients With Gastritis |
| NCT04341454 | PHASE3 | COMPLETED | Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Acute or Chronic Gastritis |
| NCT05163756 | PHASE3 | COMPLETED | To Evaluate the Efficacy and Safety of DW1903 in Acute and Chronic Gastritis Patient |
| NCT06151210 | PHASE3 | COMPLETED | Clinical Trial to Evaluate the Efficacy and Safety of DA-5219 in Patients With Acute or Chronic Gastritis |
| NCT07139886 | PHASE2 | COMPLETED | A Study to Evaluate the Safety and Efficacy of DA9601 for Acute and Chronic Gastritis and to Determine the Optimal Clinical Dosage and Administration |
| NCT02658864 | PHASE1 | COMPLETED | Pharmacokinetic Properties and Effect of Food on Pharmacokinetic Properties of the Oral Lafutidine Tablets |
| NCT04702542 | Not specified | ACTIVE_NOT_RECRUITING | To Develop Methods for the Rehabilitation of Chronic Gastroduodenal Pathology in Children. |
| NCT05021029 | Not specified | ENROLLING_BY_INVITATION | UC Davis Cohort of Pre-Malignant and Malignant Gastro-Intestinal DisEases Study |
| NCT07129824 | Not specified | NOT_YET_RECRUITING | Relationship Between Diet and Gastritis |
| NCT07542652 | Not specified | RECRUITING | Association Between Microplastic Exposure and the Pathological Progression of Gastric Carcinogenesis |
| NCT03847753 | Not specified | COMPLETED | Exploring the Comorbidity Between Mental Disorders and General Medical Conditions |
| NCT05048069 | Not specified | UNKNOWN | Post-Marketing Surveillance of Safety and Effectiveness of Mucosta®SR Tab. |
| NCT05073614 | Not specified | COMPLETED | Evaluation of Immunohistochemical Expression of Heparanase in Helicobacter Pylori-Associated Chronic Gastritis |
| NCT05666531 | Not specified | UNKNOWN | Research on Innovative Diagnosis and Treatment System of Syndrome Differentiation of Zang-fu Viscera and Effectiveness Evaluation Based on Inter-Arm Blood Pressure Measured Simultaneously |
| NCT06269380 | Not specified | COMPLETED | Evaluation of Antral Biopsies Obtained in Normal Esophagogastroduodenoscopy |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BERBERINE | 4 | 15 |
| ESOMEPRAZOLE | 4 | 5 |
| CLARITHROMYCIN | 4 | 4 |
| RABEPRAZOLE | 4 | 2 |
| VONOPRAZAN | 4 | 2 |
| AMOXICILLIN | 4 | 1 |
| FURAZOLIDONE | 4 | 1 |
| MINOCYCLINE | 4 | 1 |
| MOXIFLOXACIN | 4 | 1 |
| TETRACYCLINE | 4 | 1 |
| REBAMIPIDE | 3 | 5 |
| LAFUTIDINE | 3 | 1 |
| RECOFLAVONE | 3 | 1 |
| METERGOLINE | 2 | 1 |
| CHEMBL3137673 | 0 | 5 |
| CHEMBL1703336 | 0 | 2 |
| CHEMBL1374738 | 0 | 1 |
| CHEMBL1572167 | 0 | 1 |