Chronic hiccup

Summary

Chronic hiccup (MONDO:0018334) is a disease. A subtype of autonomic nervous system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: 1-9 / 100 000 (Europe) [Orphanet-validated]
• Phenotypes (HPO): 8

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-9 / 100 000	1	Europe	Validated

Signs & symptoms

Clinical features (HPO)

8 HPO clinical features (Orphanet curated; top 8 by frequency):

HPO ID	Term	Frequency
HP:0100247	Recurrent singultus	Very frequent (80-99%)
HP:0000716	Depression	Frequent (30-79%)
HP:0000775	Abnormality of the diaphragm	Frequent (30-79%)
HP:0001824	Weight loss	Frequent (30-79%)
HP:0001944	Dehydration	Frequent (30-79%)
HP:0002360	Sleep abnormality	Frequent (30-79%)
HP:0004395	Malnutrition	Frequent (30-79%)
HP:0100738	Abnormal eating behavior	Frequent (30-79%)

Identifiers

Disease identifiers

Field	Value
Canonical name	chronic hiccup
Mondo ID	MONDO:0018334
Orphanet	396
ICD-11	1300687612
SNOMED CT	716771000
UMLS	C0744898
MedGen	900733
GARD	0006657
NORD	1242
Is cancer (heuristic)	no

Also known as: chronic hiccups · Hiccups, Chronic · Hiccups, intractable · intractable hiccups · intractable singultus · persistent hiccups

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of autonomic nervous system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › autonomic nervous system disorder › chronic hiccup

Related subtypes (12): idiopathic peripheral autonomic neuropathy, autonomic neuropathy, autonomic nervous system neoplasm, Frey syndrome, harlequin syndrome, pure autonomic failure, baroreflex failure, autonomic dysreflexia, dysautonomia, sympathetic nervous system disorder, parasympathetic nervous system disorder, central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.