Chronic otitis media
disease diseaseOn this page
Also known as chronic otitis media (disease)otitis media (disease), chronic
Summary
Chronic otitis media (MONDO:0021204) is a disease and 19 clinical trials. Top therapeutic interventions include dexmedetomidine. A subtype of otitis media — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- ClinVar variants: 1
- Clinical trials: 19
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | chronic otitis media |
| Mondo ID | MONDO:0021204 |
| ICD-11 | 38010200 |
| SNOMED CT | 21186006 |
| UMLS | C0271441 |
| MedGen | 75751 |
| Is cancer (heuristic) | no |
Also known as: chronic otitis media (disease) · otitis media (disease), chronic
Data availability: 1 ClinVar variant.
Disease family
This is a subtype of otitis media. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › auditory system disorder › middle ear disorder › otitis media › chronic otitis media
Related subtypes (7): middle ear cholesterol granuloma, non-suppurative otitis media, otosalpingitis, suppurative otitis media, allergic otitis media, infectious otitis media, tympanitis
Subtypes (4): chronic tympanitis, chronic purulent otitis media, chronic eustachian salpingitis, chronic non-suppurative otitis media
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
ClinVar germline variants
1 retrieved; paginated sample, class counts are floors:
1 uncertain significance
| ClinVar | Variant (HGVS) | Gene | Classification | Review |
|---|---|---|---|---|
| 267932 | 46;XX;t(1;13)(q11.2;p11.2)dn | Uncertain significance | criteria provided, single submitter |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 19.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 17 |
| PHASE3 | 1 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00271778 | PHASE3 | UNKNOWN | A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media |
| NCT01188551 | PHASE2/PHASE3 | COMPLETED | Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement |
| NCT04396145 | Not specified | ACTIVE_NOT_RECRUITING | The Effects of Chronic Otitis Surgery on SVV |
| NCT00189098 | Not specified | COMPLETED | Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media |
| NCT00270660 | Not specified | UNKNOWN | A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis Media |
| NCT00941993 | Not specified | COMPLETED | Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus |
| NCT01157910 | Not specified | UNKNOWN | Bacterial Assessment of Middle Ear Fluid in Children Undergoing Ventilation Tube Placement Surgery |
| NCT01251432 | Not specified | COMPLETED | Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults |
| NCT01855425 | Not specified | COMPLETED | Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose |
| NCT02226718 | Not specified | COMPLETED | Validation of a Questionnaire for Measuring Quality of Life in Patients With Chronic Inflammation of the Middle Ear |
| NCT02495038 | Not specified | COMPLETED | Optimal Dose of Combination of Rocuronium and Cisatracurium |
| NCT02716376 | Not specified | COMPLETED | Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy |
| NCT03294421 | Not specified | UNKNOWN | Combined Access Closed Tympanomastoidectomy: Microsurgery Allied to Endoscopy |
| NCT04374266 | Not specified | COMPLETED | Tegmen Defect Management During Mastoidectomy |
| NCT04423952 | Not specified | WITHDRAWN | Validity of the French Version of the Quality of Life Questionnaire COMQ12-FR |
| NCT04864912 | Not specified | COMPLETED | Retrospective Health Care Utilisation and Current Quality of Life in Adults With Chronic Otitis Media Who Had a Middle Ear Surgery |
| NCT06398899 | Not specified | COMPLETED | Sugammadex v.s. Neostigmine/Glycopyrrolate |
| NCT07149480 | Not specified | COMPLETED | Comparison of Postoperative Outcomes of Interlay vs Underlay Graft in Tympanoplasty |
| NCT07595484 | Not specified | COMPLETED | A Prospective Comparative Study of Dry vs Wet Temporalis Fascia Graft in Tympanoplasty |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DEXMEDETOMIDINE | 4 | 1 |
Related Atlas pages
- Drugs: Dexmedetomidine