Chronic pain syndrome

Summary

Chronic pain syndrome (MONDO:0024317) is a disease and 74 clinical trials. Top therapeutic interventions include cholecalciferol, ergocalciferol, and gabapentin. A subtype of neurological pain disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 74

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	chronic pain syndrome
Mondo ID	MONDO:0024317
ICD-10-CM	G89.4
SNOMED CT	373621006
UMLS	C1298685
MedGen	720585
Is cancer (heuristic)	no

Also known as: chronic disorder involving pain · chronic pain disease · disorder involving pain, chronic

Disease family

This is a subtype of neurological pain disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › neurological pain disorder › chronic pain syndrome

Related subtypes (8): psychologic dyspareunia, paroxysmal extreme pain disorder, headache disorder, neuralgia, vulvodynia, coccygodynia, Eagle syndrome, glossodynia

Subtypes (3): fibromyalgia, complex regional pain syndrome, loin pain hematuria syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 74.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	57
PHASE3	8
PHASE1	3
PHASE4	2
PHASE2/PHASE3	2
PHASE2	1
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01417923	PHASE4	UNKNOWN	The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain
NCT03472521	PHASE4	COMPLETED	Prevention of Persistent Opioid Use in Mothers
NCT04429893	PHASE2/PHASE3	UNKNOWN	Magnesium Sulphate to Bupivicaine in Serratus Anterior Plane Block in Modified Radical Mastectomy
NCT05548738	PHASE2/PHASE3	COMPLETED	Caudal Epidural Prolotherapy Versus Steroids in Failed Back Surgery Syndrome
NCT06071936	PHASE3	UNKNOWN	Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
NCT06071949	PHASE3	UNKNOWN	Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
NCT06071962	PHASE3	UNKNOWN	Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain
NCT06071975	PHASE3	UNKNOWN	Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Diabetic Polyneuropathy
NCT06071988	PHASE3	UNKNOWN	Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
NCT06072001	PHASE3	UNKNOWN	Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
NCT06072560	PHASE3	UNKNOWN	Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain
NCT06072573	PHASE3	UNKNOWN	Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Diabetic Polyneuropathy
NCT03944447	PHASE2	UNKNOWN	Outcomes Mandate National Integration With Cannabis as Medicine
NCT05674903	PHASE1/PHASE2	COMPLETED	Deep Brain Therapy With Low-intensity Ultrasound for Generalized Chronic Pain
NCT05603702	PHASE1	RECRUITING	STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
NCT00529386	PHASE1	TERMINATED	Botox for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
NCT04473950	PHASE1	TERMINATED	The Effect of Chronic Pain on Delay Discounting in Methadone Patients
NCT03233594	Not specified	ACTIVE_NOT_RECRUITING	PET Imaging of Chronic Pain Syndromes
NCT04689646	Not specified	RECRUITING	Mind Body Syndrome Therapy for Chronic Pain
NCT05754190	Not specified	RECRUITING	Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
NCT06387706	Not specified	RECRUITING	The Development of a Gamified Web-based Pain Management Program (GAP) for Community-dwelling Older Adults With Chronic Pain
NCT06440668	Not specified	NOT_YET_RECRUITING	Management of Chronic Non-Cancer Pain With Non-Pharmacological Therapies
NCT06480786	Not specified	RECRUITING	SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
NCT06503562	Not specified	RECRUITING	Chronic Nonspecific Neck Pain and Central Nervous System Focused Treatment Program
NCT06527183	Not specified	RECRUITING	Fibromyalgia and Small Fiber Neuropathy
NCT06835868	Not specified	RECRUITING	Neuro-Pain Provides a Dynamic and Interactive Register for the Invasvive Neuromodulatory Therapies for Different Chronic Pain Syndromes. Patients Living in Belgium and Suffering From Persistent Spinal Pain Syndromes Type 2 as Well as Suffering From Complex Regional Pain Syndromes Are Included.
NCT06903962	Not specified	RECRUITING	Mind Body Intervention for Chronic Upper Extremity Pain (Repetitive Stress Injury)
NCT06929598	Not specified	RECRUITING	Shiatsu for Chronic Non-Inflammatory Pain in Children and Adolescents
NCT06964243	Not specified	RECRUITING	Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain
NCT07143396	Not specified	NOT_YET_RECRUITING	Evaluation of a Mind-Body Based Approach for Chronic Pain Treatment
NCT07313280	Not specified	ENROLLING_BY_INVITATION	Central Sensitization Syndromes and Post-Traumatic Stress in Women: Psychological Profile and Intervention
NCT07325110	Not specified	RECRUITING	Interoceptive Awareness and Function in Adolescents With Chronic Pain
NCT07331766	Not specified	ENROLLING_BY_INVITATION	Collaboratory Treatment Pathway for Chronic Pain Patients.
NCT07429019	Not specified	NOT_YET_RECRUITING	Intraoperative Bupivacaine Injection to Reduce Acute and Chronic Pain After TVT/TVT-O Surgery. Randomized Double-Blind Trial
NCT07468591	Not specified	NOT_YET_RECRUITING	Spinal Cord Stimulation for Refractory Pain Randomized Controlled Trial: the PAcStim RCT
NCT01431261	Not specified	COMPLETED	Neck Exercises, Training and Pain Management as a Treatment for Whiplash Patients With Chronic Neck Pain
NCT01778426	Not specified	COMPLETED	Post-reimbursement Study to Follow Spinal Neurostimulator Devices for Pain Therapy (French SCS Registry)
NCT01967342	Not specified	COMPLETED	Literacy-Adapted Psychosocial Treatments for Chronic Pain — Learning About Mastering/My Pain
NCT02197741	Not specified	COMPLETED	The Effect of an Additional Bolus Application in Patients With Intrathecal Opiate Administration - a Pilot Study
NCT03119896	Not specified	COMPLETED	Supporting Self-management of Chronic Pain

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CHOLECALCIFEROL	4	1
ERGOCALCIFEROL	4	1
GABAPENTIN	4	1
LACOSAMIDE	4	1
NALOXONE	4	1