Chronic periodontitis

Summary

Chronic periodontitis (MONDO:0005593) is a disease and 255 clinical trials. Top therapeutic interventions include alendronic acid, doxycycline anhydrous, and methylene blue cation. A subtype of periodontitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 255

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	chronic periodontitis
Mondo ID	MONDO:0005593
EFO	EFO:0006343
MeSH	D055113
ICD-10-CM	K05.3
ICD-11	1242548497
NCIT	C35326
SNOMED CT	5689008
Is cancer (heuristic)	no

Also known as: periodontitis, chronic

Disease family

This is a subtype of periodontitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › periodontal disorder › periodontitis › chronic periodontitis

Related subtypes (3): acute pericementitis, periapical periodontitis, pericoronitis

Subtypes (3): chronic apical periodontitis, periodontitis, chronic, adult, periodontitis, aggressive

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Azithromycin	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 255.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	146
PHASE4	32
PHASE2/PHASE3	24
PHASE2	23
PHASE3	12
PHASE1/PHASE2	8
EARLY_PHASE1	7
PHASE1	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00805558	PHASE4	COMPLETED	Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis
NCT01034501	PHASE4	COMPLETED	Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis
NCT01195493	PHASE4	COMPLETED	Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care
NCT01211223	PHASE4	COMPLETED	Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis.
NCT01532674	PHASE4	UNKNOWN	Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy
NCT01837199	PHASE4	COMPLETED	MTZ Plus AMX in the Treatment of Smokers and Non-smokers
NCT01997814	PHASE4	COMPLETED	Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis
NCT01997853	PHASE4	COMPLETED	Omega-3 Fatty Acids in Chronic Periodontitis.
NCT02014532	PHASE4	COMPLETED	Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis
NCT02197260	PHASE4	COMPLETED	Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing
NCT02218515	PHASE4	COMPLETED	Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft
NCT02355977	PHASE4	COMPLETED	The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis
NCT02391974	PHASE4	UNKNOWN	Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets
NCT02437747	PHASE4	COMPLETED	Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus
NCT02442453	PHASE4	COMPLETED	Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients
NCT02641210	PHASE4	COMPLETED	Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin
NCT02666573	PHASE4	COMPLETED	Photodynamic Therapy During Supportive Periodontal Therapy
NCT02734784	PHASE4	COMPLETED	Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy
NCT02735395	PHASE4	UNKNOWN	Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis
NCT02808988	PHASE4	COMPLETED	Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis
NCT02886676	PHASE4	COMPLETED	Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects
NCT02901743	PHASE4	COMPLETED	Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease
NCT03262701	PHASE4	TERMINATED	Adjunctive Hydrogen Peroxide for Periodontal Therapy
NCT03419429	PHASE4	COMPLETED	Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis
NCT03498404	PHASE4	COMPLETED	Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling
NCT03791099	PHASE4	UNKNOWN	Porous Metronidazole Loaded Matrix for Local Treatment of Periodontitis.
NCT03863249	PHASE4	COMPLETED	Use of the xCELLigence System for Quantification of Bacterial Biofilm’s Real Time Formation and Antibiotics Selection.
NCT04274244	PHASE4	UNKNOWN	Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.
NCT04623164	PHASE4	COMPLETED	Complex Phytoadaptogenes in Chronic Periodontitis Treatment.
NCT04767243	PHASE4	COMPLETED	Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).
NCT05759416	PHASE4	COMPLETED	Evaluation Efficacy of Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis
NCT06254118	PHASE4	COMPLETED	Treatment of Periodontitis in Menopausal Patients
NCT00997178	PHASE3	COMPLETED	Diabetes and Periodontal Therapy Trial
NCT01330082	PHASE2/PHASE3	UNKNOWN	Adjunctive Photodynamic Therapy in the Treatment of Chronic Periodontitis
NCT01870362	PHASE3	COMPLETED	Efficacy of a Probiotic Lozenge (Inersan) in Patients With Chronic Periodontitis
NCT01917292	PHASE3	COMPLETED	Impact of Periodontal Intervention on Vascular Dysfunction
NCT02033226	PHASE3	COMPLETED	Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regeneration
NCT02060032	PHASE2/PHASE3	COMPLETED	1.2% Atorvastatin and 1.2% Simvastatin in Treatment of Chronic Periodontitis
NCT02121665	PHASE3	COMPLETED	Efficacy of a Probiotic Lozenges in Chronic Periodontitis Patients.
NCT02174757	PHASE3	COMPLETED	Effect of Probiotic Inersan and Doxycycline in Chronic Periodontitis

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ALENDRONIC ACID	4	9
DOXYCYCLINE ANHYDROUS	4	3
METHYLENE BLUE CATION	4	3
MONTELUKAST	4	3
ZOLEDRONIC ACID ANHYDROUS	4	3
INDOCYANINE GREEN ACID FORM	4	2
METRONIDAZOLE	4	2
TALC	4	2
ALBENDAZOLE	4	1
AMOXICILLIN	4	1
CHLORHEXIDINE	4	1
GLUCOSAMINE	4	1
MINOCYCLINE	4	1
MOXIFLOXACIN	4	1
OLIVE OIL	4	1
SIMVASTATIN	4	1
WATER	4	1
ZINC SULFATE	4	1
ALOE	3	3
OMEGA-3 FATTY ACIDS	3	2
OZONE	3	2
ACACIA	3	1
EDETIC ACID	3	1
HONEY	3	1
LACTOSE, ANHYDROUS	3	1
LYCOPENE	3	1
PROPOLIS WAX	3	1
WITHANOLIDE D	3	1
TOLONIUM CHLORIDE	2	1
ALLYL ISOTHIOCYANATE	1	1