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Atlas / Disease / Chronic prostatitis

Chronic prostatitis

disease
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Summary

Chronic prostatitis (MONDO:0022103) is a disease with 12 GWAS associations across 4 studies and 38 clinical trials. Top therapeutic interventions include celecoxib, tamsulosin hydrochloride, and cinnamon. A subtype of prostatitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • GWAS associations: 12
  • Clinical trials: 38

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namechronic prostatitis
Mondo IDMONDO:0022103
ICD-10-CMN41.1
ICD-11249426483
NCITC26930
SNOMED CT19905009
UMLSC0085696
MedGen88454
Is cancer (heuristic)no

Also known as: chronic prostatitis

Data availability: 12 GWAS associations (4 studies).

Disease family

This is a subtype of prostatitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › male reproductive system disorder › prostate disorder › prostatitis › chronic prostatitis

Related subtypes (4): prostatocystitis, granulomatous prostatitis, gonococcal prostatitis, Trichomonas prostatitis

Genetics & variants

GWAS landscape

12 GWAS associations across 4 studies. Top hits map to 7 distinct genes (as reported by GWAS).

Top associations by p-value

rsIDp-valueGeneRisk alleleOdds ratio
rs621132142e-14KLK3G0.81
rs108868932e-12LINC01153 - RN7SKP167C1.11
rs110845963e-11LINC03103 - RNA5SP471C0.92
rs59697492e-10RBBP7, TXLNGC1.06
rs1571654e-09DLEU1T1.09
rs96986364e-09RAI2A0.89
rs4654988e-09CLPTM1LG0.93
rs64814831e-08ODAD2C1.09
rs1447078554e-08MIR4431 - ASB3G0.44

Top studies (by case count)

StudyLead authorYearCasesControlsTitle
GCST90832123Rosenthal SB202610,035420,271A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men.
GCST90832126Rosenthal SB202610,035420,271A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men.
GCST90832124Rosenthal SB20263,553102,528A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men.
GCST90832125Rosenthal SB202698746,021A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

TierVariants
Tier 1: coding0
Tier 2: splice/UTR1
Tier 3: regulatory0
Tier 4: intronic/intergenic8

MAF distribution

BucketVariants
common (>=0.05)8
low_freq (0.01-0.05)0
rare (<0.01)0
unknown1

Functional consequences

ConsequenceCount
intron_variant7
intergenic_variant1
3_prime_UTR_variant1

Top variants

rsIDChrPosAllelesMAFConsequenceGenep-valueTier
rs621132141950859281T>G0.05intron_variantKLK32e-14Tier 4: intronic/intergenic
rs1088689310121284938T>C,G0.05intron_variantLINC01153 - RN7SKP1672e-12Tier 4: intronic/intergenic
rs110845961931614073T>C0.05intergenic_variantLINC03103 - RNA5SP4713e-11Tier 4: intronic/intergenic
rs5969749X16843370T>A,C,G0.053_prime_UTR_variantRBBP7, TXLNG2e-10Tier 2: splice/UTR
rs1571651350508808C>T0.05intron_variantDLEU14e-09Tier 4: intronic/intergenic
rs9698636X17811779C>A0.05intron_variantRAI24e-09Tier 4: intronic/intergenic
rs46549851325688A>C,G,T0.05intron_variantCLPTM1L8e-09Tier 4: intronic/intergenic
rs64814831027818485T>A,C0.05intron_variantODAD21e-08Tier 4: intronic/intergenic
rs144707855252764460A>Gintron_variantMIR4431 - ASB34e-08Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 38.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified24
PHASE45
PHASE35
PHASE22
EARLY_PHASE11
PHASE11

Top trials by phase / activity

NCTPhaseStatusTitle
NCT05890235PHASE4COMPLETEDEfficacy and Safety of Ningmitai Capsule in Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
NCT06159114PHASE4COMPLETEDEfficacy and Safety of Ningmitai Capsule Alone or Combined With Celecoxib in the Treatment of CP/CPPS
NCT06345014PHASE4UNKNOWNThe Efficacy and Safety of OM-89 in Patients With Recurrent Chronic Prostatitis/Chronic Pelvic Pain Syndrome
NCT06804083PHASE4COMPLETEDBovine Colostrum Efficacy for the Treatment of Chronic Prostatitis Symptoms.
NCT07013890PHASE4COMPLETEDEfficacy of Phycocyanin and Palmitoylethanolamide for the Treatment of Chronic Prostatitis Symptoms
NCT00371033PHASE3COMPLETEDEfficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
NCT00919893PHASE3COMPLETEDEfficacy Study of a Standardized Pollen Extract Preparation (Cernilton) to Treat Inflammatory Chronic Prostatitis-Chronic Pelvic Pain Syndrome (CP-CPPS)
NCT01830829PHASE3TERMINATEDJALYN for Benign Prostatic Hyperplasia (BPH) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
NCT03629769PHASE3UNKNOWNEffects of Proxelan Somministration in Patients With Chronic Prostatitis
NCT05378646PHASE3COMPLETEDEfficiency and Safety of the Drug Ingaron (Interferon-gamma Human Recombinant) in the Treatment of Chronic Prostatitis
NCT00301405PHASE2TERMINATEDOpen-Label Study of Thalidomide for Chronic Prostatitis/Chronic Pelvic Pain
NCT03500159PHASE2TERMINATEDEfficacy and Safety of AQX-1125 in Subjects With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
NCT04976751PHASE1UNKNOWNReal World Study on the Application of Appropriate Electrophysiological Technology in the Diagnosis and Treatment of Andrology Diseases in Northwest China
NCT03946163EARLY_PHASE1COMPLETEDThe Effect of Cinnamon on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome; a Pilot Study
NCT00499317Not specifiedRECRUITINGGenetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
NCT05127616Not specifiedRECRUITINGEPPIC: Easing Pelvic Pain Interventions Clinical Research Program
NCT05868668Not specifiedRECRUITINGEfficacy of Low-intensity Shockwave vs Radial Wave for Treatment of Erectile Dysfunction and Pelvic Pain
NCT06115083Not specifiedRECRUITINGEffects of Pelvic Floor Training in Male Chronic Pelvic Pain, Correlation Between Subjective and Objective Outcomes
NCT06287970Not specifiedRECRUITINGTaVNS Improves the Symptoms of Patients With Moderate to Severe CP/CPPS
NCT06299683Not specifiedRECRUITINGPain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment
NCT07066735Not specifiedNOT_YET_RECRUITINGExtracorporeal Shock-Wave Therapy (ESWT) vs Phytotherapy vs Combined in Treatment of Chronic Prostatitis
NCT07324148Not specifiedNOT_YET_RECRUITINGAcupuncture for Erectile Dysfunction
NCT00434343Not specifiedCOMPLETEDPhysical Therapy Trial for Pelvic Pain
NCT00922012Not specifiedCOMPLETEDEfficacy of Electromagnetic Stimulation Therapy for Chronic Prostatitis and Chronic Pelvic Pain Syndrome
NCT01098279Not specifiedCOMPLETEDChronic Pelvic Pain Study of Individuals With Diagnoses or Symptoms of Interstitial Cystitis and/ or Chronic Prostatitis
NCT01738464Not specifiedCOMPLETEDMicrobiomes of Pelvic Pain
NCT01843946Not specifiedCOMPLETEDClinical Efficacy of Roxithromycin in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
NCT02514265Not specifiedCOMPLETEDTrans-MAPP Symptom Patterns Study (SPS)
NCT02588274Not specifiedCOMPLETEDEfficacy of Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome
NCT02711943Not specifiedCOMPLETEDNon Interventional Study of Levofloxacin in Chronic Prostatitis
NCT02898220Not specifiedCOMPLETEDTrans-MAPP II Study of Urologic Chronic Pelvin Pain
NCT03027076Not specifiedWITHDRAWNMicrobiome of Urologic Chronic Pelvic Pain Syndrome
NCT03543761Not specifiedCOMPLETEDLow-intensity Shockwave Therapy for Non-bacterial Prostatitis/Pelvic Pain Syndrome
NCT03641807Not specifiedUNKNOWNDifferent Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
NCT04014036Not specifiedUNKNOWNTreatment of Chronic Prostatitis/ Pelvic Pain Syndrome With Low-intensity Extracorporeal Shockwave Therapy
NCT04128280Not specifiedUNKNOWNMulti-center Clinical Observation of a New Treatment Method Based on the Pathogenesis of Obstructive Prostatitis
NCT04275297Not specifiedCOMPLETEDOptimizing Psychosocial Treatment of Interstitial Cystitis/Bladder Pain Syndrome
NCT07438184Not specifiedCOMPLETEDPeriodontal Therapy and Genitourinary Inflammation in Patients With Prostatitis and Recurrent Urinary Tract Infections

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
CELECOXIB41
TAMSULOSIN HYDROCHLORIDE41
CINNAMON31
ROSIPTOR31
SELENIUM31

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 22

This page pulls from 22 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardbsnpefogenccgwasgwas_studyhgncicd10cmicd11medgenmeshmimmondomondochildmondoparentncitorphanetsctidumls