Chronic purulent otitis media

Summary

Chronic purulent otitis media (MONDO:0001920) is a disease and 7 clinical trials. A subtype of suppurative otitis media — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 7

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	chronic purulent otitis media
Mondo ID	MONDO:0001920
DOID	DOID:14247
ICD-11	669695172
NCIT	C128386
SNOMED CT	38394007
UMLS	C0271454
MedGen	543356
Is cancer (heuristic)	no

Also known as: chronic suppurative otitis Media · chronic suppurative otitis media · CSOM · suppurative otitis media, chronic

Disease family

This is a subtype of suppurative otitis media. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › auditory system disorder › middle ear disorder › otitis media › suppurative otitis media › chronic purulent otitis media

Related subtypes (2): purulent acute otitis media, chronic tubotympanic suppurative otitis media

Subtypes (1): chronic atticoantral disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 7.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	5
PHASE2/PHASE3	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05657717	PHASE2/PHASE3	COMPLETED	Safety Profile of Applied 100% Manuka Honey in Tympanoplasty
NCT03675841	PHASE1	UNKNOWN	Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
NCT06505252	Not specified	NOT_YET_RECRUITING	Comparison of Topical Use of Platelet-rich Plasma Versus Hyaluronic Acid During Endoscopic Fat Graft Myringoplasty: a Randomized Clinical Study
NCT02779907	Not specified	UNKNOWN	Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi
NCT05133258	Not specified	COMPLETED	Antibiotic Concentration After Delivery to Middle Ear for Chronic Suppurative Otitis Media
NCT05967845	Not specified	COMPLETED	Platelet Rich Fibrin Augmented Tympanoplasty Versus Cartilage Tympanoplasty
NCT06160505	Not specified	UNKNOWN	Mastoid Obliteration Using S53P4 Bioactive Glass Versus Mastoidectomy Alone for Chronic Suppurative Otitis Media