Chronic rhinitis
diseaseOn this page
Also known as rhinitis, chronic
Summary
Chronic rhinitis (MONDO:0004514) is a disease and 32 clinical trials. Top therapeutic interventions include oxymetazoline, azelastine, and guaifenesin. A subtype of rhinitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 32
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | chronic rhinitis |
| Mondo ID | MONDO:0004514 |
| DOID | DOID:8252 |
| ICD-10-CM | J31.0 |
| ICD-11 | 1346915097 |
| NCIT | C34479 |
| SNOMED CT | 86094006 |
| UMLS | C0008711 |
| MedGen | 3086 |
| Is cancer (heuristic) | no |
Also known as: rhinitis, chronic
Disease family
This is a subtype of rhinitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › otorhinolaryngologic disease › nasal disorder › nasal cavity disorder › rhinitis › chronic rhinitis
Related subtypes (2): atrophic rhinitis, allergic rhinitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 32.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 28 |
| PHASE4 | 2 |
| PHASE2 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05626621 | PHASE4 | RECRUITING | Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis |
| NCT00737906 | PHASE4 | TERMINATED | Surgical Reduction of the Inferior Turbinates for Nasal Obstruction |
| NCT01364467 | PHASE2 | COMPLETED | The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study |
| NCT07168148 | PHASE2 | TERMINATED | Steroid Treatment for Elimination of Rebound Obstruction From Intranasal Decongestants |
| NCT05937308 | Not specified | ACTIVE_NOT_RECRUITING | NEUROMARK Registry Study |
| NCT06370468 | Not specified | RECRUITING | The Epidemiological and Intrinsic Characteristics of Chronic Rhinitis |
| NCT06598319 | Not specified | RECRUITING | Evaluation of Pulsed Field Ablation of the Posterior Nasal Nerve for Chronic Rhinitis |
| NCT06599736 | Not specified | ACTIVE_NOT_RECRUITING | A Study of RhinAer Stylus for Treating Chronic Rhinitis |
| NCT06678334 | Not specified | NOT_YET_RECRUITING | Characteristic Transcriptomic, Proteomic and Metabolomic Molecular Studies of Nasal Secretions From Chronic Rhinitis |
| NCT06682676 | Not specified | NOT_YET_RECRUITING | Diagnostic Efficacy of CDA Nasal Provocation Test in Patients With IR |
| NCT06999044 | Not specified | RECRUITING | Study on the Optimization of the Diagnostic Process for Chronic Rhinitis Using Nasal Allergen Provocation Test |
| NCT07050992 | Not specified | ACTIVE_NOT_RECRUITING | Laser Posterior Nasal Nerve Neurolysis |
| NCT07323888 | Not specified | ACTIVE_NOT_RECRUITING | Traditional vs. Posterior Nasal Radiofrequency Ablation for Chronic Rhinitis |
| NCT07568548 | Not specified | NOT_YET_RECRUITING | Efficacy and Safety of High-Concentration 35 kDa Hyaluronan Gel for Chronic Nasopharyngitis |
| NCT00584662 | Not specified | TERMINATED | Oxymetazoline Hydrochloride in Combination With Nasal Glucocorticosteroid for Perennial Allergic and Non-allergic Rhinitis in Subjects With Persistent Nasal Congestion |
| NCT01546662 | Not specified | UNKNOWN | A Randomized Double Dummy Double Blind Dose Determining Place-bo Controlled Study to Evaluate Efficacy of Investigational Product E-RH-06 at 2 Dose Levels for the Metabolic Management of Chronic or Recurrent, Non-infective Nasal Congestion With-or-without Rhinorrhea. |
| NCT03181594 | Not specified | COMPLETED | Evaluation of the ClariFix™ Cryotherapy Device in Subjects With Chronic Rhinitis |
| NCT03727347 | Not specified | COMPLETED | Posterior Nasal Nerve (PNN) Rhinitis Study |
| NCT03739216 | Not specified | COMPLETED | Registry of Subject Treated With ClariFix |
| NCT03791489 | Not specified | COMPLETED | Multi-Treatment PNN Modulation for Chronic Rhinitis |
| NCT03893227 | Not specified | COMPLETED | Prevalence of Nasal Hyperreactivity in Chronic Upper Airway Inflammation |
| NCT04154605 | Not specified | COMPLETED | ClariFix Rhinitis RCT |
| NCT04375293 | Not specified | COMPLETED | Characterisation of the Nasal Microbiome in Patients With N-ERD |
| NCT04533438 | Not specified | COMPLETED | RhinAer Procedure for Treatment of Chronic Rhinitis Study |
| NCT04614324 | Not specified | COMPLETED | A Study of RhinAer ARC Stylus for Treating Chronic Rhinitis (RELIEF) |
| NCT04684875 | Not specified | COMPLETED | Quality of Life Impact of Chronic Rhinitis Treatment With Aerin Medical Device |
| NCT04769596 | Not specified | COMPLETED | Safety and Efficacy Study of the Neurent Medical NEUROMARK™ System in Subjects With Chronic Rhinitis |
| NCT05324397 | Not specified | COMPLETED | Safety and Efficacy Study of the Neurent Medical NEUROMARK™ System in Subjects With Chronic Rhinitis (CLARITY) |
| NCT05331222 | Not specified | TERMINATED | Proof-of-Concept Interventional Study With a Nasal Spray of JT-1 in Patients With Chronic Rhinitis or Chronic Sinusitis |
| NCT05591989 | Not specified | COMPLETED | Clinical Evaluation of Safety and Efficacy for the NEUROMARK System in Subjects With Chronic Rhinitis (PARAGON) |
| NCT05648565 | Not specified | COMPLETED | Effects of Radiofrequency Ablation of Posterior Nasal Nerves on Inflammatory Cytokines, Peak Nasal Inspiratory Flow, and Nasal Blood Flow in Patients With Chronic Rhinitis |
| NCT06128200 | Not specified | COMPLETED | NEUROMARK Randomized Controlled Trial |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| OXYMETAZOLINE | 4 | 6 |
| AZELASTINE | 4 | 3 |
| GUAIFENESIN | 4 | 1 |
| TRIAMCINOLONE | 4 | 1 |
| MOMETASONE | 3 | 1 |
| CHEMBL2392189 | 0 | 1 |
Related Atlas pages
- Drugs: Oxymetazoline, Azelastine, Guaifenesin, Triamcinolone, Mometasone