Chronic tic disorder
disease diseaseOn this page
Also known as chronic motor or vocal tic disordertic disorder, chronic
Summary
Chronic tic disorder (MONDO:0001074) is a disease and 17 clinical trials. Top therapeutic interventions include aripiprazole, tiapride, and levcycloserine. A subtype of tic disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 17
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | chronic tic disorder |
| Mondo ID | MONDO:0001074 |
| DOID | DOID:10600 |
| ICD-10-CM | F95.1 |
| NCIT | C116768 |
| UMLS | C0008701 |
| MedGen | 40301 |
| Is cancer (heuristic) | no |
Also known as: chronic motor or vocal tic disorder · tic disorder, chronic
Disease family
This is a subtype of tic disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › mental disorder › developmental disorder of mental health › specific developmental disorder › tic disorder › chronic tic disorder
Related subtypes (2): transient tic disorder, Tourette syndrome
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 17.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 13 |
| PHASE3 | 2 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00706589 | PHASE3 | COMPLETED | Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette’s Disorder |
| NCT01501695 | PHASE3 | COMPLETED | Phase III Study of 5LGr to Treat Tic Disorder |
| NCT02247206 | PHASE2 | COMPLETED | VoIP Delivered Behavior Therapy for Tourette Syndrome |
| NCT01440023 | PHASE1 | COMPLETED | Developing Cognitive Training for Tourette Syndrome |
| NCT06270251 | Not specified | RECRUITING | Modeling Tic Change During Behavior Therapy for Tics |
| NCT06271083 | Not specified | RECRUITING | Internet-based Behavior Therapy for Adults With Tourette Syndrome |
| NCT00486551 | Not specified | COMPLETED | Anger Control Training for Youth With Tourette Syndrome |
| NCT01177774 | Not specified | COMPLETED | Assessment of Children With Tic Onset in the Past 6 Months |
| NCT01702077 | Not specified | COMPLETED | Neurofeedback for Tourette Syndrome |
| NCT02067819 | Not specified | COMPLETED | Proof of Concept Study of an Oral Orthotic to Reduce Tic Severity in Chronic Tic Disorder and Tourette Syndrome |
| NCT02114905 | Not specified | COMPLETED | Dissemination of Comprehensive Behavioral Intervention for Tics (CBIT) to Occupational Therapists: A Feasibility Study |
| NCT02582515 | Not specified | COMPLETED | Augmentation of Brief Habit Reversal Training With D-cycloserine or Placebo |
| NCT04087616 | Not specified | UNKNOWN | Internet-based CBIT for Children With Chronic Tics |
| NCT04594044 | Not specified | COMPLETED | Group Therapy Versus Individual Therapy for Tourette Syndrome and Chronic Tic Disorder |
| NCT04678180 | Not specified | UNKNOWN | Treatment Outcome of Combined Virtual Tic Training in Children and Adolescents With a Chronic Tic Disorder |
| NCT04908969 | Not specified | UNKNOWN | Internet-based Cognitive Behavioral Therapy for Chronic Tic Disorder and Tourette’s Disorder: a Feasibility Trial |
| NCT05269953 | Not specified | COMPLETED | Median Nerve Stimulation for Tourette Syndrome and Chronic Tic Disorder |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ARIPIPRAZOLE | 4 | 1 |
| TIAPRIDE | 3 | 1 |
| LEVCYCLOSERINE | 2 | 1 |
Related Atlas pages
- Drugs: Aripiprazole, Tiapride