Circadian rhythm sleep disorder, shift work type

Summary

Circadian rhythm sleep disorder, shift work type (MONDO:0024382) is a disease and 25 clinical trials. Top therapeutic interventions include solriamfetol. A subtype of circadian rhythm sleep disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 25

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	circadian rhythm sleep disorder, shift work type
Mondo ID	MONDO:0024382
ICD-10-CM	G47.26
SNOMED CT	713498009
UMLS	C0393773
MedGen	501114
Is cancer (heuristic)	no

Also known as: circadian rhythm sleep disorder of shift work type · shift work disorder

Disease family

This is a subtype of circadian rhythm sleep disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › sleep disorder › sleep-wake disorder › circadian rhythm sleep disorder › circadian rhythm sleep disorder, shift work type

Related subtypes (7): advanced sleep phase syndrome, non-24-hour sleep-wake syndrome, rapid eye movement sleep disorder, circadian rhythm sleep disorder, delayed sleep phase type, circadian rhythm sleep disorder, advanced sleep phase type, circadian rhythm sleep disorder, irregular sleep wake type, circadian rhythm sleep disorder, jet lag type

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 25.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	23
PHASE4	1
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04788953	PHASE4	TERMINATED	Clinical Trial of Solriamfetol for Excessive Sleepiness Related to Shift Work Disorder
NCT06568367	PHASE3	RECRUITING	Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)
NCT04869098	Not specified	RECRUITING	Effects of an Evening PROtein PrEload on Metabolic Health in Night ShIfT Workers (PROPENSITy)
NCT04966351	Not specified	RECRUITING	Countermeasures to Circadian Misalignment
NCT05153759	Not specified	RECRUITING	EMS Providers’ Health Initiative Study
NCT05424406	Not specified	RECRUITING	Role of Sleep Reactivity in Shift Work Disorder
NCT06288568	Not specified	RECRUITING	Night Shift Work and Biomarkers of Obesity Risk in Hospital and Industry Workers
NCT06422741	Not specified	RECRUITING	Effect of a Grape Seed Proanthocyanidin Extract (GSPE) on LDL Cholesterol Levels in Rotating Night Shift Workers
NCT06440434	Not specified	ACTIVE_NOT_RECRUITING	Effects of Morningness on Night Split Shift Performance
NCT06492109	Not specified	RECRUITING	The Peripheral Blood Multi-Omics Study on Sleep Loss
NCT06550115	Not specified	RECRUITING	Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers
NCT07028788	Not specified	NOT_YET_RECRUITING	Virtual Mindfulness and Breathing Training for Stress, Burnout, Sleep, and Cognition in Rotating-Shift Nurses
NCT07394283	Not specified	NOT_YET_RECRUITING	Impact of Night Shift Work on Dietary Habits Among Intensive Care and Emergency Healthcare Workers (NUTRINIGHT)
NCT07426211	Not specified	NOT_YET_RECRUITING	Impact of Shift Work on Glucose and Lipid Metabolism of Hospital Workers
NCT07592052	Not specified	NOT_YET_RECRUITING	Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption
NCT00950885	Not specified	COMPLETED	Melatonin Treatment for Induced Transient Insomnia
NCT02997319	Not specified	COMPLETED	Shift Work, Heredity, Insulin, and Food Timing Study
NCT04813536	Not specified	UNKNOWN	Shift Work Health Effects
NCT04955431	Not specified	COMPLETED	Circadian Rhythm Disruption Effects on Smoke Inhalation
NCT05074277	Not specified	COMPLETED	Skeletal Response to Simulated Night Shift
NCT05091021	Not specified	COMPLETED	Skeletal Effects of Chronic Night Shift
NCT05186233	Not specified	COMPLETED	Use of Consumer Sleep Technology to Treat Shift Work Disorder
NCT05452096	Not specified	UNKNOWN	SHIFTPLAN: an RCT Investigating the Effect of a Shift Work Intervention on Fatigue, Sleep and Health.
NCT05633498	Not specified	COMPLETED	Self-help Book for Shift Work Related Problems
NCT05962112	Not specified	UNKNOWN	Metabolic Implications of Day and Night-shift Working on NHS Healthcare Staff

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
SOLRIAMFETOL	4	6