Cocaine intoxication

Summary

Cocaine intoxication (MONDO:0019544) is a disease and 2 clinical trials. A subtype of poisoning — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: 1-9 / 100 000 (Europe) [Orphanet-validated]
• Phenotypes (HPO): 63
• Clinical trials: 2

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-9 / 100 000	1	Europe	Validated

Signs & symptoms

Clinical features (HPO)

63 HPO clinical features (Orphanet curated; top 50 by frequency):

HPO ID	Term	Frequency
HP:0000709	Psychosis	Frequent (30-79%)
HP:0000713	Agitation	Frequent (30-79%)
HP:0000725	Psychotic episodes	Frequent (30-79%)
HP:0000822	Hypertension	Frequent (30-79%)
HP:0000975	Hyperhidrosis	Frequent (30-79%)
HP:0001649	Tachycardia	Frequent (30-79%)
HP:0001945	Fever	Frequent (30-79%)
HP:0011499	Mydriasis	Frequent (30-79%)
HP:0011999	Paranoia	Frequent (30-79%)
HP:0100749	Chest pain	Frequent (30-79%)
HP:0100754	Mania	Frequent (30-79%)
HP:0000093	Proteinuria	Occasional (5-29%)
HP:0001658	Myocardial infarction	Occasional (5-29%)
HP:0002013	Vomiting	Occasional (5-29%)
HP:0002018	Nausea	Occasional (5-29%)
HP:0002027	Abdominal pain	Occasional (5-29%)
HP:0002107	Pneumothorax	Occasional (5-29%)
HP:0002113	Pulmonary infiltrates	Occasional (5-29%)
HP:0002789	Tachypnea	Occasional (5-29%)
HP:0003236	Elevated circulating creatine kinase concentration	Occasional (5-29%)
HP:0004372	Reduced consciousness/confusion	Occasional (5-29%)
HP:0005115	Supraventricular arrhythmia	Occasional (5-29%)
HP:0006803	Vivid hallucinations	Occasional (5-29%)
HP:0008765	Auditory hallucinations	Occasional (5-29%)
HP:0012735	Cough	Occasional (5-29%)
HP:0025421	Pneumomediastinum	Occasional (5-29%)
HP:0025435	Increased circulating lactate dehydrogenase concentration	Occasional (5-29%)
HP:0030157	Flank pain	Occasional (5-29%)
HP:0030828	Wheezing	Occasional (5-29%)
HP:0031258	Delirium	Occasional (5-29%)
HP:0100598	Pulmonary edema	Occasional (5-29%)
HP:0000099	Glomerulonephritis	Very rare (<1-4%)
HP:0000746	Delusion	Very rare (<1-4%)
HP:0000790	Hematuria	Very rare (<1-4%)
HP:0001250	Seizure	Very rare (<1-4%)
HP:0001259	Coma	Very rare (<1-4%)
HP:0001337	Tremor	Very rare (<1-4%)
HP:0001342	Cerebral hemorrhage	Very rare (<1-4%)
HP:0001657	Prolonged QT interval	Very rare (<1-4%)
HP:0001919	Acute kidney injury	Very rare (<1-4%)
HP:0001970	Tubulointerstitial nephritis	Very rare (<1-4%)
HP:0002069	Bilateral tonic-clonic seizure	Very rare (<1-4%)
HP:0002098	Respiratory distress	Very rare (<1-4%)
HP:0002105	Hemoptysis	Very rare (<1-4%)
HP:0002133	Status epilepticus	Very rare (<1-4%)
HP:0002138	Subarachnoid hemorrhage	Very rare (<1-4%)
HP:0002140	Ischemic stroke	Very rare (<1-4%)
HP:0002583	Colitis	Very rare (<1-4%)
HP:0002615	Hypotension	Very rare (<1-4%)
HP:0002647	Aortic dissection	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	cocaine intoxication
Mondo ID	MONDO:0019544
Orphanet	90068
ICD-11	1965837313
SNOMED CT	27956007
Is cancer (heuristic)	no

Disease family

This is a subtype of poisoning. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › poisoning › cocaine intoxication

Related subtypes (58): toxic oil syndrome, infantile mercury poisoning, ketamine-induced biliary dilatation, manganese poisoning, cyanide-induced parkinsonism, colchicine poisoning, methanol poisoning, ethylene glycol poisoning, paraquat poisoning, lead poisoning, mercury poisoning, acute opioid poisoning, acute tricyclic antidepressant poisoning, acute poisoning by drugs with membrane-stabilizing effect, snakebite envenomation, paracetamol poisoning, cyanide poisoning, scorpion envenomation, argyria, acute ackee fruit intoxication, systemic monochloroacetate poisoning, water intoxication, cassavism, formaldehyde poisoning, heavy metal poisoning, abacavir toxicity, allopurinol toxicity, codeine toxicity, efavirenz toxicity, flucloxacilline toxicity, isoniazid toxicity, raltegravir toxicity, voriconazole toxicity, curariform drugs toxicity, statin toxicity, phenytoin or carbamazepine toxicity, letrozole toxicity, ricin poisoning, ivermectin toxicity, belinostat toxicity or dose selection, toxicity to dolutegravir, mycotoxicosis, ciguatera fish poisoning, lathyrism, cadmium poisoning, phenytoin toxicity, nerve agent poisoning, local anesthetic poisoning, fire ant poisoning, aflatoxicosis, black widow spider envenomation, platinum-induced ototoxicity, carbon monoxide poisoning, organophosphate poisoning, sulfur mustard poisoning, cardiac glycoside intoxication, monochloroacetic acid poisoning, chemotherapy-induced toxicity

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04996056	PHASE2	WITHDRAWN	An Open-Label, Randomized Pilot Study Comparing the Safety of a Single Dose of TNX-1300 to Usual Care (UC) Alone for the Treatment of Signs and Symptoms of Acute Cocaine Intoxication in Male Emergency Department (ED) Subjects
NCT06045793	PHASE2	TERMINATED	Comparing Efficacy & Safety Of TNX-1300 To Placebo With UC For Treatment Of Acute Cocaine Intoxication In ED Subjects (CATALYST)