Colon adenoma
diseaseOn this page
Also known as adenoma of colonadenoma of the coloncolonic adenoma
Summary
Colon adenoma (MONDO:0000527) is a cancer and 98 clinical trials. Top therapeutic interventions include bisacodyl, sodium chloride, and polyethylene glycol. A subtype of colorectal adenoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 98
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | colon adenoma |
| Mondo ID | MONDO:0000527 |
| DOID | DOID:0050912 |
| NCIT | C3864 |
| UMLS | C4551463 |
| MedGen | 1639098 |
| Anatomy (UBERON) | UBERON:0001155 |
| Is cancer (heuristic) | yes |
Also known as: adenoma of colon · adenoma of the colon · colon adenoma · colonic adenoma
Disease family
This is a subtype of colorectal adenoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › intestinal neoplasm › colorectal neoplasm › colorectal adenoma › colon adenoma
Related subtypes (3): rectum adenoma, colorectal sessile serrated adenoma/polyp, colorectal tubulovillous adenoma
Subtypes (4): appendix adenoma, colon sessile serrated adenoma/polyp, adenomatous colon polyp, villous adenoma of colon
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 98.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 90 |
| PHASE3 | 4 |
| PHASE4 | 3 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01609855 | PHASE4 | UNKNOWN | Does the Hyoscine N-Butylbromide Administered During Colonoscopy Increase the Adenoma Detection Rate? |
| NCT03742232 | PHASE4 | COMPLETED | Study Comparing the Bowel Cleansing Efficacy of PLENVU® Versus SELG-ESSE® Using a 2-Day Split Dosing Regimen. |
| NCT04758156 | PHASE4 | UNKNOWN | Comparison Between a 1L of Polyethylene Glycol+Ascorbic Acid as a Split Dose Bowel Preparation for Colonoscopy |
| NCT00224679 | PHASE3 | TERMINATED | APACC Study:Prospective Study on Aspirin Efficacy in Reducing Colorectal Adenoma Recurrence |
| NCT01778192 | PHASE3 | COMPLETED | A Randomized Prospective Trial Comparing Polyethylene Glycol and Sodium Picosulphate With Magnesium Citrate |
| NCT02250196 | PHASE3 | COMPLETED | A Randomized Prospective Trial Comparing Low-volume Bowel Preparation Methods |
| NCT02980562 | PHASE3 | COMPLETED | Comparison of Low Volume PEG-Asc and Lower Volume PEG-Asc With Bisacodyl |
| NCT03631641 | PHASE2 | TERMINATED | Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History of Partial Colectomy |
| NCT03471793 | Not specified | RECRUITING | The Australian Colonic Large Sessile Lesion Endoscopic Resection Study |
| NCT05041478 | Not specified | RECRUITING | Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC) |
| NCT05355363 | Not specified | RECRUITING | Risk of Metachronous Findings After Detection of Serrated Lesions and High-grade Dysplasia With Surveillance Delay |
| NCT05402696 | Not specified | RECRUITING | St. Paul’s Advanced Resection Center Cohort for Colorectal Neoplasia (SPARC-C) |
| NCT06462521 | Not specified | ENROLLING_BY_INVITATION | Cold Snare Piecemeal Resection vs Cold Snare Endoscopic Mucosal Resection |
| NCT06550908 | Not specified | RECRUITING | Training Physicians to Differentiate the Paris Classification Using Artificial Colon Polyp Images |
| NCT06792292 | Not specified | NOT_YET_RECRUITING | Artificial Intelligence-Assisted Colonoscopy in Colorectal Cancer Screening in a General Hospital |
| NCT07127471 | Not specified | RECRUITING | Computer-Aided Water Exchange Colonoscopy With and Without Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions |
| NCT07308743 | Not specified | NOT_YET_RECRUITING | Impact of Computer-aided Detection System on the Proximal Adenoma Miss Rate |
| NCT07450612 | Not specified | RECRUITING | Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection |
| NCT01422577 | Not specified | COMPLETED | Diagnosis of Colonic Adenomas by Bright Narrow Band Imaging (B-NBI) |
| NCT01483040 | Not specified | COMPLETED | PeerScope B System™ Clinical Protocol |
| NCT01719198 | Not specified | UNKNOWN | Usefulness of Calprotectin for Colon Adenoma Screening |
| NCT01737567 | Not specified | WITHDRAWN | Comparison Between White Light Endoscopy and Bright Narrow Band Imaging in Diagnosis Colonic Adenomas. |
| NCT01789749 | Not specified | COMPLETED | Soft Coagulation for the Prevention of Adenoma Recurrence |
| NCT01952418 | Not specified | COMPLETED | Effect of Video Monitor Size on Adenoma Detection Rate |
| NCT01989650 | Not specified | COMPLETED | The Effect of Taking Break During Colonoscopy Session on Adenoma Detection, a Prospective, Randomized Control Study |
| NCT01992406 | Not specified | UNKNOWN | Feasibility, Safety and Outcome of Transrectal Hybrid-NOTES Anterior Resection |
| NCT02009774 | Not specified | COMPLETED | Accuracy of the Optical Diagnosis of Small Colonic Polyps Using the Nice Classification |
| NCT02057562 | Not specified | UNKNOWN | Impact of Diverticular Disease on the Detection of Colon Adenomas |
| NCT02178033 | Not specified | UNKNOWN | The Impact of Split Dose of Low-volume Polyethylene Glycol on Adenoma Detection Rate |
| NCT02665299 | Not specified | COMPLETED | Plasma ctDNA in Patients Undergoing Diagnostic Colonoscopy |
| NCT02665741 | Not specified | COMPLETED | Comparison of Colon Adenoma Detection Rate Using Two Distal Colonoscope Attachments |
| NCT02724306 | Not specified | COMPLETED | Physical Activity Intervention With People at Increased Risk of Developing Colon Cancer |
| NCT02819492 | Not specified | COMPLETED | Side Specific Withdrawal Times for Colonoscopy: Impact on Adenoma Detection in the Proximal and Distal Colon |
| NCT02838888 | Not specified | UNKNOWN | Computer-assisted Detection of Colonic Polyps |
| NCT02957058 | Not specified | COMPLETED | PROSpective Assessment of Post EmR Recurrence |
| NCT03139942 | Not specified | COMPLETED | Optical Polyp Testing for In Vivo Classification |
| NCT03243669 | Not specified | COMPLETED | High Definition Endoscopy and Virtual Chromoendoscopy Versus Standard Resolution Endoscopy in Detection of Colon Polyps |
| NCT03254498 | Not specified | COMPLETED | Detection in Tandem Endocuff Cap Trial |
| NCT03336359 | Not specified | COMPLETED | Linked Color Imaging Versus Narrow Band Imaging for Colorectal Adenoma Detection |
| NCT03344055 | Not specified | COMPLETED | Endocuff-assisted Colonoscopy vs Standard Colonoscopy on Adenoma Detection Rate |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BISACODYL | 4 | 1 |
| SODIUM CHLORIDE | 4 | 1 |
| POLYETHYLENE GLYCOL | 3 | 2 |
| POLYETHYLENE GLYCOL 4000 | 3 | 1 |