Colon neuroendocrine neoplasm
diseaseOn this page
Also known as colon NETcolon neuroendocrine tumorcolon neuroendocrine tumor, well differentiated, low or intermediate gradecolon neuroendocrine tumourcolonic neuroendocrine neoplasmcolonic neuroendocrine tumourneuroendocrine neoplasm of colonneuroendocrine neoplasm of the colonneuroendocrine tumour of the colon
Summary
Colon neuroendocrine neoplasm (MONDO:0002882) is a cancer. A subtype of intestinal neuroendocrine neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Phenotypes (HPO): 22
Clinical features
Signs & symptoms
Clinical features (HPO)
22 HPO clinical features (Orphanet curated; top 22 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0100570 | Carcinoid tumor | Obligate (100%) |
| HP:0001824 | Weight loss | Frequent (30-79%) |
| HP:0002027 | Abdominal pain | Frequent (30-79%) |
| HP:0002039 | Anorexia | Frequent (30-79%) |
| HP:0002240 | Hepatomegaly | Frequent (30-79%) |
| HP:0002730 | Chronic noninfectious lymphadenopathy | Frequent (30-79%) |
| HP:0025085 | Bloody diarrhea | Frequent (30-79%) |
| HP:0030144 | Hypoactive bowel sounds | Frequent (30-79%) |
| HP:0030446 | Atypical pulmonary carcinoid tumor | Frequent (30-79%) |
| HP:4000007 | Bronchoconstriction | Occasional (5-29%) |
| HP:0001708 | Right ventricular failure | Occasional (5-29%) |
| HP:0001962 | Palpitations | Occasional (5-29%) |
| HP:0002249 | Melena | Occasional (5-29%) |
| HP:0002615 | Hypotension | Occasional (5-29%) |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | Occasional (5-29%) |
| HP:0003144 | Increased serum serotonin | Occasional (5-29%) |
| HP:0004385 | Protracted diarrhea | Occasional (5-29%) |
| HP:0005180 | Tricuspid regurgitation | Occasional (5-29%) |
| HP:0007380 | Facial telangiectasia | Occasional (5-29%) |
| HP:0012701 | Bowel urgency | Occasional (5-29%) |
| HP:0030145 | Lack of bowel sounds | Occasional (5-29%) |
| HP:0031566 | Abnormal pulmonary valve cusp morphology | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | colon neuroendocrine neoplasm |
| Mondo ID | MONDO:0002882 |
| Orphanet | 100080 |
| DOID | DOID:4118 |
| ICD-11 | 144503516 |
| NCIT | C5697 |
| UMLS | C1333097 |
| MedGen | 234162 |
| GARD | 0019755 |
| Anatomy (UBERON) | UBERON:0001155 |
| Is cancer (heuristic) | yes |
Also known as: colon NET · colon neuroendocrine neoplasm · colon neuroendocrine tumor · colon neuroendocrine tumor, well differentiated, low or intermediate grade · colon neuroendocrine tumour · colonic neuroendocrine neoplasm · colonic neuroendocrine tumour · neuroendocrine neoplasm of colon · neuroendocrine neoplasm of the colon · neuroendocrine tumour of the colon
Disease family
This is a subtype of intestinal neuroendocrine neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › intestinal neoplasm › intestinal neuroendocrine neoplasm › colon neuroendocrine neoplasm
Related subtypes (3): rectum neuroendocrine neoplasm, small intestine neuroendocrine neoplasm, intestinal neuroendocrine tumor G1
Subtypes (3): colon small cell neuroendocrine carcinoma, neuroendocrine tumor of the colon, well differentiated, low or intermediate grade tumor, appendix neuroendocrine neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.