Colonic disorder
diseaseOn this page
Also known as colon diseasecolon disease or disorderdisease of colondisease or disorder of colondisorder of colon
Summary
Colonic disorder (MONDO:0003409) is a disease (an umbrella term covering 13 Mondo subtypes) and 38 clinical trials. Top therapeutic interventions include ibrutinib, lactulose, and polyethylene glycol 3350. A subtype of large intestine disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Umbrella term: 13 Mondo subtypes
- Clinical trials: 38
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | colonic disorder |
| Mondo ID | MONDO:0003409 |
| MeSH | D003108 |
| DOID | DOID:5353 |
| SNOMED CT | 128524007 |
| UMLS | C0009373 |
| MedGen | 1049 |
| Anatomy (UBERON) | UBERON:0001155 |
| Is cancer (heuristic) | no |
Also known as: colon disease · colon disease or disorder · disease of colon · disease or disorder of colon · disorder of colon
Disease family
An umbrella term covering 13 Mondo subtypes.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › large intestine disorder › colonic disorder
Related subtypes (10): anal canal cancer, rectal disorder, colorectal neoplasm, Crohn’s colitis, epithelial tumor of anal canal, shigellosis, polyp of large intestine, benign neoplasm of large intestine, colorectal Kaposi sarcoma, disorder of appendix
Subtypes (13): neuronal intestinal dysplasia, functional diarrhea, megacolon, diverticulitis of colon, cecal disorder, sigmoid disease, functional colonic disease, colitis, colonic neoplasm, colon dysplasia, polyp of colon, Chilaiditi syndrome, colonic duplication
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 38.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 33 |
| PHASE4 | 3 |
| PHASE3 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05436054 | PHASE4 | RECRUITING | A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy |
| NCT03428724 | PHASE4 | UNKNOWN | Individualized Bowel Preparation for Colonoscopy |
| NCT04708366 | PHASE4 | UNKNOWN | Colon Cleansing Efficacy With 1L vs. 2L vs. 4L-PEG for Colonoscopy Among Inpatients |
| NCT02304523 | PHASE3 | COMPLETED | Safety and Efficacy of CDFR0612 and CDFR0613 for Bowel Cleansing Before Colonoscopy |
| NCT03332498 | PHASE1/PHASE2 | COMPLETED | Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers |
| NCT05520229 | Not specified | NOT_YET_RECRUITING | The Evaluation of a Preanaesthesia Assessment Clinic |
| NCT05551052 | Not specified | ACTIVE_NOT_RECRUITING | CRC Detection Reliable Assessment With Blood |
| NCT06265649 | Not specified | RECRUITING | Comparison of NOM for ACLD Between Medical and Surgical Ward |
| NCT06288464 | Not specified | RECRUITING | Enteral Feeding of Fibre to Improve Microbiota |
| NCT06874036 | Not specified | RECRUITING | Safety, Efficacy and Tolerability of Bowel Preparation and Colonoscopy in Patient With CHD, CKD and CLD |
| NCT07450612 | Not specified | RECRUITING | Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection |
| NCT01320826 | Not specified | COMPLETED | The Alberta Primary Care Endoscopy (APC-Endo) Study |
| NCT01322737 | Not specified | COMPLETED | Feasibility Trial to Evaluate the Ability of the SuMO Tissue Access and Resection System |
| NCT01483040 | Not specified | COMPLETED | PeerScope B System™ Clinical Protocol |
| NCT01762735 | Not specified | UNKNOWN | Water Injection Colonoscopy vs Air Insufflation Colonoscopy in Training the Beginners |
| NCT01871584 | Not specified | UNKNOWN | A Post Marketing Study of Angel of Water™ for Colon Cleansing as Preparation for Colonoscopy |
| NCT02955901 | Not specified | COMPLETED | 3-day vs. 1-day Low Residue Diet Influence in Colonoscopy Preparation and Patient Tolerability |
| NCT03148054 | Not specified | COMPLETED | Computed Tomography vs. Endoscopy Study |
| NCT03279705 | Not specified | COMPLETED | The efficacy of the Integrated Water Jet Channel Colonoscopy in Water Exchange Method |
| NCT03633539 | Not specified | WITHDRAWN | Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer |
| NCT03638713 | Not specified | COMPLETED | Comparison of Procedural Sequences in Same-day Painless Bidirectional Endoscopy With Colonoscopic Water Exchange Method |
| NCT03763266 | Not specified | COMPLETED | Low Residue Diet During 3 Days vs 1 Day Prior Colonoscopy |
| NCT03949777 | Not specified | COMPLETED | Validation of Aer-O-Scope Colonoscope System Cecal Intubation |
| NCT04344964 | Not specified | COMPLETED | Endoscopy-related Phone Consultation During the COVID-19 Outbreak |
| NCT04369053 | Not specified | COMPLETED | Prevention of Colorectal Cancer Through Multiomics Blood Testing |
| NCT04428229 | Not specified | COMPLETED | Optic Nerve Sheath Diameter in Laparoscopic Surgeries During Trendelenburg Position |
| NCT04624334 | Not specified | TERMINATED | Non-invasive Assessment of Colonic Motility |
| NCT04794049 | Not specified | UNKNOWN | Comparison of Oral Lactulose Versus Polyethylene Glycol for Bowel Preparation |
| NCT04829032 | Not specified | UNKNOWN | GOODBYE HARTMANN TRIAL: 100 YEARS OF HARTMANN’S PROCEDURE |
| NCT04895254 | Not specified | COMPLETED | Colonoscopy Using Motorized Spiral Enteroscope |
| NCT05174845 | Not specified | COMPLETED | Real Word Evidence With 1L Polyethylene Glycol (PEG)+ Ascorbic Acid in Iberia |
| NCT05231473 | Not specified | COMPLETED | Impact Of The Nurse Enhanced Recovery After Surgery Coordinator On The Compliance In Colorectal Surgery (nursERAS-BCN) |
| NCT05378165 | Not specified | COMPLETED | Three Distraction Methods for Pain Reduction During Colonoscopy |
| NCT05392452 | Not specified | COMPLETED | Fully Closed-Loop Insulin Delivery in Abdominal Surgery (CLAB) |
| NCT05715905 | Not specified | UNKNOWN | Analyzing Clinical Trial Experiences of Colon Cancer Patients |
| NCT05801757 | Not specified | COMPLETED | Continuous Infusion of Remidazolam for Colonoscopic Polypectomy in Elderly Patients |
| NCT05973266 | Not specified | UNKNOWN | The Effect of Mobile Application-Based Bowel Preparation Training on the Patient’s Education Whom Colonoscopy is Planned |
| NCT06073782 | Not specified | COMPLETED | Patient Education and Text Message Reminders in Colonoscopy |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| IBRUTINIB | 4 | 1 |
| LACTULOSE | 4 | 1 |
| POLYETHYLENE GLYCOL 3350 | 4 | 1 |
| POLYETHYLENE GLYCOL | 3 | 1 |