Combat disorder
diseaseOn this page
Also known as combat neurosescombat neurosiscombat stress disordercombat stress disordersdisorder, combatdisorder, combat stressdisorders, combatdisorders, combat stressneuroses, combatneuroses, warneurosis, combatneurosis, warshell shockshell Shocksshock, shellShocks, shellstress disorder, combatstress disorders, combatwar neuroses
Summary
Combat disorder (MONDO:0004049) is a disease and 33 clinical trials. Top therapeutic interventions include prazosin hydrochloride, cycloserine, and omega-3-acid ethyl esters. A subtype of acute stress disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 33
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | combat disorder |
| Mondo ID | MONDO:0004049 |
| MeSH | D003130 |
| DOID | DOID:6950 |
| SNOMED CT | 279611005 |
| UMLS | C0009426 |
| MedGen | 40403 |
| Is cancer (heuristic) | no |
Also known as: combat disorder · combat neuroses · combat neurosis · combat stress disorder · combat stress disorders · disorder, combat · disorder, combat stress · disorders, combat · disorders, combat stress · neuroses, combat · neuroses, war · neurosis, combat · neurosis, war · shell shock · shell Shocks · shock, shell · Shocks, shell · stress disorder, combat · stress disorders, combat · war neuroses (+1 more)
Disease family
This is a subtype of acute stress disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › mental disorder › anxiety disorder › acute stress disorder › combat disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 33.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 27 |
| PHASE2 | 3 |
| PHASE4 | 1 |
| PHASE2/PHASE3 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00292370 | PHASE4 | COMPLETED | Quetiapine Augmentation for Treatment-resistant PTSD |
| NCT00475241 | PHASE2/PHASE3 | COMPLETED | Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms |
| NCT01216982 | PHASE2 | UNKNOWN | Effects of Omega-3 EPA/DHA for Soldiers at Risk for Mood Disorders |
| NCT02266329 | PHASE1/PHASE2 | COMPLETED | Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin |
| NCT02809326 | PHASE2 | COMPLETED | Trauma Management Therapy for OEF and OIF Combat Veterans |
| NCT04264026 | PHASE2 | COMPLETED | MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD |
| NCT05414708 | Not specified | RECRUITING | Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms |
| NCT05900479 | Not specified | ACTIVE_NOT_RECRUITING | Multi-site, Longitudinal Trial Evaluating the Efficacy, Mechanisms, and Moderators of Service Dogs for Military Veterans With PTSD |
| NCT06723834 | Not specified | ENROLLING_BY_INVITATION | Service Dogs and Prolonged Exposure Therapy for Military-Connected PTSD |
| NCT00285246 | Not specified | COMPLETED | Prospective Study of Veteran Health in Previously Deployed Soldiers |
| NCT00371176 | Not specified | COMPLETED | A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD |
| NCT00419029 | Not specified | COMPLETED | Motivational Interviewing to Engage Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans in Mental Health Treatment |
| NCT00539279 | Not specified | COMPLETED | Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder |
| NCT00870545 | Not specified | COMPLETED | Reintegration: The Role of Spouse Telephone BATTLEMIND Pilot Study |
| NCT00974402 | Not specified | COMPLETED | Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings |
| NCT00990106 | Not specified | COMPLETED | Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD) |
| NCT01007006 | Not specified | WITHDRAWN | Telepharmacy Robotic Medicine Delivery Unit TRMDU Assessment |
| NCT01049516 | Not specified | COMPLETED | Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) Among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Personnel |
| NCT01062022 | Not specified | TERMINATED | FOCUS-CI: A Preventive Intervention With Children and Families of the Combat Injured |
| NCT01330888 | Not specified | COMPLETED | Exploring Deployment Stress and Reintegration in Army National Guard Chaplains |
| NCT01338506 | Not specified | COMPLETED | Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders |
| NCT02226367 | Not specified | COMPLETED | Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD |
| NCT02556645 | Not specified | COMPLETED | A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel |
| NCT02720497 | Not specified | COMPLETED | The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD |
| NCT02825602 | Not specified | UNKNOWN | Vietnam Era Health Retrospective Observational Study |
| NCT03337750 | Not specified | COMPLETED | An Open-Trial of Web-Prolonged Exposure (Web-PE) Among Active-Duty Military |
| NCT03736356 | Not specified | TERMINATED | Long-term Health Outcomes of AE Casualties |
| NCT03795987 | Not specified | COMPLETED | Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken) |
| NCT03828656 | Not specified | UNKNOWN | NightWare Open Enrollment Study |
| NCT03934658 | Not specified | COMPLETED | Remote Study of NightWare for PTSD With Nightmares |
| NCT03995992 | Not specified | UNKNOWN | Benefits of Diving Training on Recovery for Veterans Suffering of Chronic PTSD: an Exploratory Study |
| NCT04040387 | Not specified | COMPLETED | NightWare Randomized Trial 02 |
| NCT04776304 | Not specified | COMPLETED | Art Therapy QEEG Study for Service Members with a Traumatic Brain Injury and Posttraumatic Stress Symptoms |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PRAZOSIN HYDROCHLORIDE | 4 | 3 |
| CYCLOSERINE | 4 | 1 |
| OMEGA-3-ACID ETHYL ESTERS | 4 | 1 |
| QUETIAPINE | 4 | 1 |
| MIDOMAFETAMINE | 3 | 1 |
| LEVCYCLOSERINE | 2 | 1 |
| CHEMBL4547032 | 0 | 1 |