Common cold
diseaseOn this page
Also known as acute nasopharyngitisacute nasopharyngitis [common cold]acute rhinitis
Summary
Common cold (MONDO:0005709) is a disease and 115 clinical trials. Top therapeutic interventions include acetaminophen, dextromethorphan, and oxymetazoline. A subtype of nasopharyngitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 115
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | common cold |
| Mondo ID | MONDO:0005709 |
| EFO | EFO:0007214 |
| MeSH | D003139 |
| DOID | DOID:10459 |
| ICD-10-CM | J00 |
| NCIT | C34500 |
| SNOMED CT | 82272006 |
| UMLS | C0009443 |
| MedGen | 3179 |
| Is cancer (heuristic) | no |
Also known as: acute nasopharyngitis · acute nasopharyngitis [common cold] · acute rhinitis
Disease family
This is a subtype of nasopharyngitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › upper respiratory tract disorder › nasopharyngeal disorder › nasopharyngitis › common cold
Related subtypes (1): adenoiditis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
8 approved, 11 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Acetaminophen | Approved (phase 4) |
| Aspirin | Approved (phase 4) |
| Camphor | Approved (phase 4) |
| Ibuprofen | Approved (phase 4) |
| Menthol | Approved (phase 4) |
| Naproxen | Approved (phase 4) |
| Pseudoephedrine | Approved (phase 4) |
| Sodium Chloride | Approved (phase 4) |
| Acetylcysteine | Phase 3 (in late-stage trials) |
| Caffeine | Phase 3 (in late-stage trials) |
| Capsaicin | Phase 3 (in late-stage trials) |
| Desloratadine | Phase 3 (in late-stage trials) |
| Echinacea, Unspecified | Phase 3 (in late-stage trials) |
| Lidocaine | Phase 3 (in late-stage trials) |
| Naphazoline | Phase 3 (in late-stage trials) |
| Panthenol | Phase 3 (in late-stage trials) |
| Pheniramine | Phase 3 (in late-stage trials) |
| Phenylephrine | Phase 3 (in late-stage trials) |
| Xylometazoline | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): 2-DEOXY-D-GLUCOSE, Cholecalciferol, Dextrose, Guaifenesin.
Clinical trials & evidence
Clinical trials
Clinical trials: 115.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 43 |
| PHASE3 | 29 |
| PHASE2 | 18 |
| PHASE4 | 16 |
| PHASE1 | 7 |
| PHASE1/PHASE2 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00378144 | PHASE4 | COMPLETED | Efficacy and Safety of Sinutab on Subjects in the Setting of a Common Cold |
| NCT01033526 | PHASE4 | COMPLETED | Symptomatic Treatment of Common Cold Symptoms |
| NCT01257542 | PHASE4 | TERMINATED | Acute Cough Study In Children |
| NCT01332578 | PHASE4 | COMPLETED | A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies |
| NCT01465009 | PHASE4 | COMPLETED | Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold |
| NCT01466348 | PHASE4 | COMPLETED | Effects of a Common Cold Treatment on Cognitive Function |
| NCT01728090 | PHASE4 | COMPLETED | Effectiveness of a Handwashing Programme in the Prevention of School Absenteeism Due to Respiratory Infections |
| NCT01944631 | PHASE4 | COMPLETED | Iota-Carrageenan Nasal Spray in Common Cold |
| NCT02246166 | PHASE4 | COMPLETED | The Effect of Paracetamol, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Tablets Compared to Placebo in Subjects Suffering From the Common Cold or Influenza. |
| NCT02981147 | PHASE4 | COMPLETED | PEACe: Ivy, Thyme and Cisti Extract (Phytus) Efficacy in Acute Cough |
| NCT03070314 | PHASE4 | WITHDRAWN | Echinaforce Junior Bioavailability Trial |
| NCT03154515 | PHASE4 | COMPLETED | Efficacy and Safety Study of Ingavirin® 90 mg Once Daily to Treat Influenza and Other Acute Viral Infections in Adults |
| NCT05002179 | PHASE4 | COMPLETED | Echinaforce Study to Investigate Explorative Pharmacology and Effectiveness to Prevent From Enveloped Virus Infections |
| NCT05556148 | PHASE4 | COMPLETED | Otrivine: Quality of Life (QoL) Impact in a Real-World Setting |
| NCT06315400 | PHASE4 | UNKNOWN | Efficacy and Safety of Ingavirin®, Capsules, 60 mg, in Children With Influenza and Other Acute Respiratory Viral Infections |
| NCT06716645 | PHASE4 | COMPLETED | A Clinical Evidence Study Evaluating Quality of Life Parameters Following Treatment With Robitussin |
| NCT06531707 | PHASE3 | RECRUITING | Efficacy and Safety in the Combination of Ibuprofen / Loratadine Versus Ibuprofen Versus Loratadine |
| NCT06697886 | PHASE3 | RECRUITING | A Study of the Efficacy and Safety of Antiwei Granules in the Treatment of Common Cold |
| NCT00029211 | PHASE3 | COMPLETED | A Trial of Echinacea in Children |
| NCT00065715 | PHASE3 | COMPLETED | Echinacea Versus Placebo Effect in Common Cold (Physician Echinacea Placebo) |
| NCT00231218 | PHASE3 | COMPLETED | Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers |
| NCT00452270 | PHASE3 | COMPLETED | Decongestant Effect, Timing of Effect and Impact on Sleep and General Well-Being of Xylometazoline in Subjects With a Common Cold |
| NCT00617318 | PHASE3 | COMPLETED | Pomegranate Products for Prevention of Common Cold |
| NCT00940836 | PHASE3 | UNKNOWN | Efficacy and Safety Assessment of an Anti-Cold Preparation in the Symptomatic Treatment of Common Cold and Flu-Like Syndrome |
| NCT00963443 | PHASE3 | COMPLETED | Acetylsalicylic Acid Combined With Pseudoephedrine in Common Cold |
| NCT00967759 | PHASE3 | WITHDRAWN | Study Comparing 3 Formulations to Evaluate the Efficacy and Safety of the Inflammatory Symptoms of the Upper Respiratory Tract, in Children Between 2 and 6 Years Old |
| NCT01062360 | PHASE3 | COMPLETED | Placebo and Active Controlled Study to Assess Efficacy and Tolerability of Aspirin Plus Pseudoephedrine |
| NCT01158326 | PHASE3 | COMPLETED | Evaluation of Efficacy and Safety of Oral Solution Resfenol in Reducing Symptoms of Common Cold And Flu |
| NCT01361399 | PHASE3 | COMPLETED | Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold |
| NCT01459952 | PHASE3 | COMPLETED | A Double-blind, Randomised, Parallel Group,Comparative Study With Rose-hip Liquid and Placebo Given to Healthy Volunteers in the Winter Season Aiming to Evaluate the Occurences of Flu and Catching a Cold |
| NCT01686646 | PHASE3 | COMPLETED | Effects of Two Doses of a Common Cold Treatment on Alertness |
| NCT01938144 | PHASE3 | WITHDRAWN | Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America |
| NCT01964885 | PHASE3 | TERMINATED | Benefit and Tolerability of IQP-AS-105 in Reducing Susceptibility to Upper Respiratory Tract Infections |
| NCT02174653 | PHASE3 | COMPLETED | Safety and Intake Effect of EPs® 7630 (an Extract of the Roots of Pelargonium Sidoides) |
| NCT02644018 | PHASE3 | COMPLETED | Efficacy and Safety Study of Ingavirin® to Treat Influenza and Other Acute Respiratory Viral Infections in Patients 3-6 y.o. |
| NCT02656888 | PHASE3 | WITHDRAWN | Efficacy and Safety of Irlanda-1-Association on the Treatment of Common Cold in Children |
| NCT02656914 | PHASE3 | WITHDRAWN | Efficacy and Safety of Irlanda-2 Association on the Treatment of Common Cold |
| NCT02822287 | PHASE3 | COMPLETED | Warming Sensation and Tolerability Study of Acetylcysteine 2% Oral Solution for Productive Cough |
| NCT03189537 | PHASE3 | COMPLETED | Study of Post-Exposure Ingavirin® Prophylaxis of Influenza and Acute Respiratory Viral Infections |
| NCT03191097 | PHASE3 | COMPLETED | Efficacy and Safety Study of Ingavirin® to Treat Influenza and Acute Respiratory Viral Infections in Children 7-12 y.o. |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ACETAMINOPHEN | 4 | 9 |
| DEXTROMETHORPHAN | 4 | 3 |
| OXYMETAZOLINE | 4 | 3 |
| PSEUDOEPHEDRINE | 4 | 3 |
| ASCORBIC ACID | 4 | 2 |
| CAFFEINE | 4 | 2 |
| DEXTROSE | 4 | 2 |
| PHENYLEPHRINE | 4 | 2 |
| XYLOMETAZOLINE | 4 | 2 |
| GLUCAGON | 4 | 1 |
| GUAIFENESIN | 4 | 1 |
| LORATADINE | 4 | 1 |
| INGAVIRIN | 3 | 4 |
| ECHINACEA, UNSPECIFIED | 3 | 3 |
| 2-DEOXY-D-GLUCOSE | 3 | 1 |
| CAMPHOR | 3 | 1 |
| MALTODEXTRIN | 3 | 1 |
| RESVERATROL | 3 | 1 |
| TIMAPIPRANT | 3 | 1 |
| CARBOMER 910 | 2 | 1 |
| GLUCOSE OXIDASE | 2 | 1 |
| PLECONARIL | 2 | 1 |
| CHEMBL5592090 | 0 | 4 |
| CHEMBL1377788 | 0 | 2 |
| PARAXANTHINE | 0 | 2 |
| CHEMBL2392189 | 0 | 1 |
| CHEMBL1316134 | 0 | 1 |
| CHEMBL4175452 | 0 | 1 |
| CHEMBL4303562 | 0 | 1 |
| 1,5-Anhydrosorbitol | 0 | 1 |