Congenital enterovirus infection

Summary

Congenital enterovirus infection (MONDO:0017375) is a disease. A subtype of enterovirus infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 39

Clinical features

Signs & symptoms

Clinical features (HPO)

39 HPO clinical features (Orphanet curated; top 39 by frequency):

HPO ID	Term	Frequency
HP:0000988	Skin rash	Very frequent (80-99%)
HP:0000707	Abnormality of the nervous system	Frequent (30-79%)
HP:0000737	Irritability	Frequent (30-79%)
HP:0001287	Meningitis	Frequent (30-79%)
HP:0001873	Thrombocytopenia	Frequent (30-79%)
HP:0001945	Fever	Frequent (30-79%)
HP:0002086	Abnormality of the respiratory system	Frequent (30-79%)
HP:0025031	Abnormality of the digestive system	Frequent (30-79%)
HP:0100806	Sepsis	Frequent (30-79%)
HP:0001396	Cholestasis	Occasional (5-29%)
HP:0001399	Hepatic failure	Occasional (5-29%)
HP:0001558	Decreased fetal movement	Occasional (5-29%)
HP:0001561	Polyhydramnios	Occasional (5-29%)
HP:0001622	Premature birth	Occasional (5-29%)
HP:0001638	Cardiomyopathy	Occasional (5-29%)
HP:0001698	Pericardial effusion	Occasional (5-29%)
HP:0001789	Hydrops fetalis	Occasional (5-29%)
HP:0001791	Fetal ascites	Occasional (5-29%)
HP:0001875	Decreased total neutrophil count	Occasional (5-29%)
HP:0001882	Leukopenia	Occasional (5-29%)
HP:0001892	Abnormal bleeding	Occasional (5-29%)
HP:0001903	Anemia	Occasional (5-29%)
HP:0001974	Leukocytosis	Occasional (5-29%)
HP:0002098	Respiratory distress	Occasional (5-29%)
HP:0002119	Ventriculomegaly	Occasional (5-29%)
HP:0002202	Pleural effusion	Occasional (5-29%)
HP:0002383	Infectious encephalitis	Occasional (5-29%)
HP:0002615	Hypotension	Occasional (5-29%)
HP:0003073	Hypoalbuminemia	Occasional (5-29%)
HP:0005521	Disseminated intravascular coagulation	Occasional (5-29%)
HP:0011121	Abnormal skin morphology	Occasional (5-29%)
HP:0012115	Hepatitis	Occasional (5-29%)
HP:0012758	Neurodevelopmental delay	Occasional (5-29%)
HP:0012819	Myocarditis	Occasional (5-29%)
HP:0025116	Fetal distress	Occasional (5-29%)
HP:0200149	CSF lymphocytic pleiocytosis	Occasional (5-29%)
HP:0001987	Hyperammonemia	Very rare (<1-4%)
HP:0002045	Hypothermia	Very rare (<1-4%)
HP:0004311	Abnormal macrophage morphology	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	congenital enterovirus infection
Mondo ID	MONDO:0017375
Orphanet	292
ICD-11	1981771784
SNOMED CT	716865000
UMLS	C4274223
MedGen	904399
GARD	0002130
Is cancer (heuristic)	no

Also known as: antenatal enterovirus infection · congenital enterovirus infection · congenital enterovirus infectious disease · congenital infection caused by enterovirus · mother-to-child transmission of enterovirus infection

Disease family

This is a subtype of enterovirus infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › Picornaviridae infectious disease › enterovirus infectious disease › congenital enterovirus infection

Related subtypes (5): coxsackievirus infectious disease, Echovirus infectious disease, enterovirus antenatal infection, fetal enterovirus syndrome, poliovirus infection

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.