Congenital herpes simplex virus infection

Summary

Congenital herpes simplex virus infection (MONDO:0017381) is a disease and 1 clinical trial. A subtype of herpes simplex infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 4
• Clinical trials: 1

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	1-9 / 100 000	6.6	Sweden	Not yet validated
Annual incidence	1-9 / 100 000	1.6	United Kingdom	Not yet validated

Signs & symptoms

Clinical features (HPO)

4 HPO clinical features (Orphanet curated; top 4 by frequency):

HPO ID	Term	Frequency
HP:0001511	Intrauterine growth retardation	Frequent (30-79%)
HP:0001622	Premature birth	Frequent (30-79%)
HP:0000252	Microcephaly	Occasional (5-29%)
HP:0002324	Hydranencephaly	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	congenital herpes simplex virus infection
Mondo ID	MONDO:0017381
Orphanet	293
SNOMED CT	91576008
UMLS	C0276225
MedGen	82910
GARD	0018687
Is cancer (heuristic)	no

Also known as: antenatal herpes simplex virus infection · congenital herpes simplex · mother-to-child transmission of herpes simplex virus infection · neonatal herpes simplex virus infection · neonatal HSV infection · Simplexvirus caused infectious embryofetopathy · Simplexvirus infectious embryofetopathy

Disease family

This is a subtype of herpes simplex infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › Herpesviridae infectious disease › herpes simplex infectious disease › congenital herpes simplex virus infection

Related subtypes (9): herpetic whitlow, herpes simplex dermatitis, genital herpes, herpes simplex virus gingivostomatitis, herpes simplex encephalitis, herpes simplex virus keratitis, herpes labialis, herpes simplex type 1 infectious disease, herpes simplex type 2 infectious disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05226949	Not specified	COMPLETED	Host RNA Expression Profiles and Protein Biomarkers in Neonatal Herpes Simplex Virus Infection