Conversion disorder
disease diseaseOn this page
Also known as conversion hysterical neurosisFNDfunctional movement disorderfunctional neurological disorder
Summary
Conversion disorder (MONDO:0002104) is a disease and 65 clinical trials. Top therapeutic interventions include sertraline. A subtype of somatoform disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 65
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | conversion disorder |
| Mondo ID | MONDO:0002104 |
| MeSH | D003291 |
| DOID | DOID:1768 |
| UMLS | C0009946 |
| MedGen | 3230 |
| Is cancer (heuristic) | no |
Also known as: conversion hysterical neurosis · FND · functional movement disorder · functional neurological disorder
Disease family
This is a subtype of somatoform disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › somatoform disorder › conversion disorder
Related subtypes (5): body dysmorphic disorder, neurocirculatory asthenia, hypochondriasis, somatization disorder, physiological malfunction arising from mental factor
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 65.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 61 |
| PHASE4 | 2 |
| PHASE1/PHASE2 | 1 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00159965 | PHASE4 | COMPLETED | Treatments for Psychogenic Nonepileptic Seizures (NES) |
| NCT00835627 | PHASE4 | COMPLETED | Treatment Trial for Psychogenic Nonepileptic Seizures |
| NCT05155059 | PHASE2 | ACTIVE_NOT_RECRUITING | Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in Functional Movement Disorders |
| NCT01422278 | PHASE1/PHASE2 | UNKNOWN | Rehabilitation of Conversion Gait Disorder |
| NCT04097184 | Not specified | RECRUITING | Efficacy of Dorso-lateral Prefrontal Cortex Stimulation by tDCS in Motor Conversion Disorder Patients |
| NCT04662372 | Not specified | ACTIVE_NOT_RECRUITING | Functional Neurological Disorders in Patients Admitted in Stroke Units |
| NCT05723276 | Not specified | ACTIVE_NOT_RECRUITING | Psilocybin in Functional Neurological Disorder |
| NCT05943652 | Not specified | RECRUITING | Observational Study on Functional Overlay in Patients With Movement Disorders |
| NCT06257069 | Not specified | ACTIVE_NOT_RECRUITING | Tremor Retrainer Software Application for Functional Tremor |
| NCT06362161 | Not specified | RECRUITING | Establishment of an Interdisciplinary Functional Neurological Disorder (FND) Treatment Program and Development of a Clinical Care Pathway for FND |
| NCT06393439 | Not specified | RECRUITING | Virtual Reality in Functional Movement Disorder |
| NCT06422819 | Not specified | RECRUITING | Clinical Evaluation of HRV Biofeedback in Functional Neurological Disorders Compared to Placebo |
| NCT06439017 | Not specified | NOT_YET_RECRUITING | Passive Thoughts in Functional Movement Disorders |
| NCT06726135 | Not specified | NOT_YET_RECRUITING | The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study |
| NCT06792760 | Not specified | ENROLLING_BY_INVITATION | Additive Effects of Interoceptive Training to Physiotherapy in Functional Movement Disorders (interoPTfmd) |
| NCT06872788 | Not specified | NOT_YET_RECRUITING | Study of Sensory Attenuation in Functional Movement Disorders |
| NCT06873698 | Not specified | RECRUITING | Pilot Neurobehavioral Therapy for Functional Neurological Disorder |
| NCT07006415 | Not specified | NOT_YET_RECRUITING | Brain-computer Interface Rehabilitation And Virtual Environments in Functional Neurological Disorder (BRAVE-FND) |
| NCT07077603 | Not specified | NOT_YET_RECRUITING | The Feasibility and Acceptability of an Online Yoga Program for People With Functional Neurological Disorders |
| NCT07302308 | Not specified | NOT_YET_RECRUITING | Action Outcome Latencies as a Measure of Sense of Agency in Functional Movement Disorders. |
| NCT07372755 | Not specified | NOT_YET_RECRUITING | Feasibility and Usability of a Mobile App for Monitoring and Managing Functional Movement Disorders |
| NCT07378488 | Not specified | RECRUITING | Dance/Movement Therapy for Functional Neurological Disorder |
| NCT07478666 | Not specified | RECRUITING | Feasibility of Remotely Measured Activity Behavior for Individuals With Functional Neurologic Disorder |
| NCT07527403 | Not specified | RECRUITING | Impact of Theta Burst Repetitive Transcranial Magnetic Stimulation on the Patient’s Self-reported Improvement in Their Motor Functional Neurological Disorder |
| NCT07538414 | Not specified | RECRUITING | Investigation of Patients Presenting With Acute Functional Neurological Symptoms |
| NCT07588282 | Not specified | RECRUITING | The Effect of Psychoeducational Diagnosis Communication on Perception of Illness, Satisfaction, and Behavioral Intentions Among Patients With Functional Neurological Movement Disorders |
| NCT00448084 | Not specified | COMPLETED | Brain Activity in People With Functional Movement Disorders |
| NCT00971360 | Not specified | COMPLETED | Cytokine Levels in Conversion Disorder |
| NCT02102906 | Not specified | COMPLETED | TMS and Attentional Bias in Functional Motor Disorder |
| NCT02275000 | Not specified | COMPLETED | Feasibility Study of Physiotherapy for Functional Motor Symptoms |
| NCT02325544 | Not specified | COMPLETED | Comparing Different Treatments in Reducing Dissociative Seizure Occurrence |
| NCT02329626 | Not specified | COMPLETED | Metabolic Anomolies Associated With the 6 Month Clinical Evolution of Patients Suffering From Motor Conversion Disorder |
| NCT02764476 | Not specified | TERMINATED | Embodied Virtual Reality Therapy for Functional Neurological Symptom/ Conversion Disorder |
| NCT02905877 | Not specified | COMPLETED | The Pathophysiology of Functional Neurological Disorders |
| NCT03325374 | Not specified | COMPLETED | BLB Study Back or Leg Pain and Bladder Symptoms Study |
| NCT03398070 | Not specified | COMPLETED | Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders |
| NCT03441867 | Not specified | UNKNOWN | Neuroimaging Biomarker for Seizures |
| NCT03660098 | Not specified | COMPLETED | Mirror Box Therapy As a Treatment Option for Functional Movement Disorders |
| NCT03661021 | Not specified | COMPLETED | Study of the Ability of a New Technique to Effectively Diagnose Movement Disorders |
| NCT03717376 | Not specified | COMPLETED | Movement Disorders and Early Maladaptive Schemas |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| SERTRALINE | 4 | 2 |
| CHEMBL1788361 | 0 | 2 |
Related Atlas pages
- Drugs: Sertraline