Corneal ectasia
diseaseOn this page
Summary
Corneal ectasia (MONDO:0001950) is a disease and 35 clinical trials. Top therapeutic interventions include riboflavin, dextran, and dextran 1. A subtype of corneal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 35
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | corneal ectasia |
| Mondo ID | MONDO:0001950 |
| DOID | DOID:1436 |
| ICD-10-CM | H18.71 |
| ICD-11 | 1703179358 |
| SNOMED CT | 14748007 |
| UMLS | C0155135 |
| MedGen | 509803 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of corneal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › corneal disorder › corneal ectasia
Related subtypes (23): cornea plana, pseudopterygium, corneal deposit, Bowman’s membrane folds or rupture, corneal degeneration, corneal staphyloma, corneal argyrosis, keratopathy, keratitis, corneal edema, brittle cornea syndrome, megalocornea, X-linked corneal dermoid, Peters anomaly, pellucid marginal degeneration, keratoconus, corneal dystrophy, sclerocornea, cornea neoplasm, Arnold stickler bourne syndrome, limbal stem cell deficiency, thygeson superficial punctate keratopathy, Terrien marginal degeneration
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 35.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 14 |
| PHASE3 | 8 |
| PHASE2/PHASE3 | 3 |
| PHASE2 | 3 |
| PHASE1/PHASE2 | 3 |
| PHASE1 | 3 |
| PHASE4 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07474870 | PHASE4 | NOT_YET_RECRUITING | Outcomes of CTAK Surgery |
| NCT03922542 | PHASE2/PHASE3 | RECRUITING | Comparison of Standard vs. Accelerated Corneal Crosslinking |
| NCT00567671 | PHASE2/PHASE3 | COMPLETED | Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia |
| NCT00679666 | PHASE2/PHASE3 | WITHDRAWN | Corneal Crosslinking in Keratoconus and Corneal Ectasia |
| NCT01112072 | PHASE3 | UNKNOWN | Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia |
| NCT01152541 | PHASE3 | UNKNOWN | Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin |
| NCT01459679 | PHASE3 | TERMINATED | Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery |
| NCT01464268 | PHASE3 | UNKNOWN | Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia |
| NCT01643252 | PHASE3 | WITHDRAWN | Safety and Efficacy Study for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery |
| NCT04897503 | PHASE3 | UNKNOWN | Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose |
| NCT04905108 | PHASE3 | UNKNOWN | Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia |
| NCT05027295 | PHASE3 | UNKNOWN | Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light |
| NCT04094090 | PHASE2 | RECRUITING | Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia |
| NCT01325298 | PHASE2 | UNKNOWN | UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia |
| NCT02883478 | PHASE1/PHASE2 | UNKNOWN | Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL). |
| NCT04213885 | PHASE2 | COMPLETED | Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position |
| NCT04401865 | PHASE1/PHASE2 | UNKNOWN | Safety and Effectiveness of the PXL-Platinum 330 System |
| NCT05241145 | PHASE1/PHASE2 | COMPLETED | Safety and Preliminary Efficacy of IVMED-80 Eye Drops in Keratoconus Patients |
| NCT02009709 | PHASE1 | UNKNOWN | Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2 |
| NCT04177082 | PHASE1 | COMPLETED | Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution |
| NCT04667572 | PHASE1 | COMPLETED | Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution |
| NCT04251143 | Not specified | RECRUITING | Dresden Corneal Disease and Treatment Study |
| NCT04698590 | Not specified | ACTIVE_NOT_RECRUITING | Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism |
| NCT01123057 | Not specified | UNKNOWN | Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia |
| NCT03319082 | Not specified | UNKNOWN | Observational Registry to Assess the Durability of Effect of CXL in Patients With Corneal Ectasia After Refractive Surgery |
| NCT03708575 | Not specified | UNKNOWN | Evaluating Risk Factors of Post-LASIK Ectasia |
| NCT03913338 | Not specified | COMPLETED | Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia |
| NCT04405882 | Not specified | COMPLETED | Cornea Ectasia Excimer Laser Treatment |
| NCT04433936 | Not specified | COMPLETED | Corneal Tomographic Parameters in TGD |
| NCT04475900 | Not specified | COMPLETED | Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics |
| NCT04763785 | Not specified | UNKNOWN | Development of a Keratoconus Detection Algorithm by Deep Learning Analysis and Its Validation on Eyestar Images |
| NCT05691335 | Not specified | COMPLETED | Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus |
| NCT06347900 | Not specified | COMPLETED | Corneal Topographic Changes in Different Grades of OSA |
| NCT06348368 | Not specified | COMPLETED | Refractive and Corneal Topographic Characteristics in Upper Egypt Children With High Cylinder |
| NCT06859398 | Not specified | COMPLETED | KeratoConus Data Acquisition With Topography and Aberrometry |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| RIBOFLAVIN | 4 | 10 |
| DEXTRAN | 3 | 1 |
| DEXTRAN 1 | 2 | 1 |
| CHEMBL511565 | 0 | 10 |
| CHEMBL5267279 | 0 | 10 |
Related Atlas pages
- Drugs: Riboflavin, Dextran