Corneal intraepithelial neoplasm

Summary

Corneal intraepithelial neoplasm (MONDO:0003801) is a cancer and 1 clinical trial. Top therapeutic interventions include interferon alfa-2b and mitomycin. A subtype of cornea neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	corneal intraepithelial neoplasm
Mondo ID	MONDO:0003801
DOID	DOID:6198
NCIT	C6093
SNOMED CT	420835009
UMLS	C1333159
MedGen	232396
Anatomy (UBERON)	UBERON:0000964
Is cancer (heuristic)	yes

Also known as: cornea intraepithelial neoplasia · cornea squamous cell intraepithelial neoplasia · corneal intraepithelial neoplasia · intraepithelial neoplasia of cornea · intraepithelial neoplasia of the cornea

Disease family

This is a subtype of cornea neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › corneal disorder › cornea neoplasm › corneal intraepithelial neoplasm

Related subtypes (2): cornea cancer, benign neoplasm of cornea

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE4	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02199327	PHASE4	COMPLETED	Topical Interferon Alfa 2b and Mitomycin C in Conjunctival-Corneal Intraepithelial Neoplasia

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
INTERFERON ALFA-2B	4	1
MITOMYCIN	4	1
CHEMBL4071382	0	1
CHEMBL5175144	0	1