Coronary arterial fistulas

Summary

Coronary arterial fistulas (MONDO:0016081) is a disease. A subtype of coronary artery congenital malformation — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 27

Clinical features

Signs & symptoms

Clinical features (HPO)

27 HPO clinical features (Orphanet curated; top 27 by frequency):

HPO ID	Term	Frequency
HP:0001635	Congestive heart failure	Frequent (30-79%)
HP:0001640	Cardiomegaly	Frequent (30-79%)
HP:0001649	Tachycardia	Frequent (30-79%)
HP:0002875	Exertional dyspnea	Frequent (30-79%)
HP:0003115	Abnormal EKG	Frequent (30-79%)
HP:0005162	Abnormal left ventricular function	Frequent (30-79%)
HP:0031664	Systolic heart murmur	Frequent (30-79%)
HP:0031670	Continuous heart murmur	Frequent (30-79%)
HP:0001279	Syncope	Occasional (5-29%)
HP:0001627	Abnormal heart morphology	Occasional (5-29%)
HP:0001631	Atrial septal defect	Occasional (5-29%)
HP:0001643	Patent ductus arteriosus	Occasional (5-29%)
HP:0001647	Bicuspid aortic valve	Occasional (5-29%)
HP:0001650	Aortic valve stenosis	Occasional (5-29%)
HP:0001655	Patent foramen ovale	Occasional (5-29%)
HP:0001681	Angina pectoris	Occasional (5-29%)
HP:0001962	Palpitations	Occasional (5-29%)
HP:0002092	Pulmonary arterial hypertension	Occasional (5-29%)
HP:0002617	Dilatation	Occasional (5-29%)
HP:0002789	Tachypnea	Occasional (5-29%)
HP:0005133	Right ventricular dilatation	Occasional (5-29%)
HP:0006689	Bacterial endocarditis	Occasional (5-29%)
HP:0010741	Pedal edema	Occasional (5-29%)
HP:0011675	Arrhythmia	Occasional (5-29%)
HP:0012764	Orthopnea	Occasional (5-29%)
HP:0030848	Elevated jugular venous pressure	Occasional (5-29%)
HP:0030882	Coronary artery aneurysm	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	coronary arterial fistulas
Mondo ID	MONDO:0016081
Orphanet	2041
UMLS	C0265898
MedGen	488822
GARD	0001533
MedDRA	10069441
Is cancer (heuristic)	no

Also known as: Coronaro-cardiac fistula · coronary arterial malformations

Disease family

This is a subtype of coronary artery congenital malformation. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › arterial disorder › coronary artery disorder › coronary artery congenital malformation › coronary arterial fistulas

Related subtypes (8): anomalous left coronary artery from the pulmonary artery, congenital coronary artery aneurysm, coronary artery intramyocardial course, aortopulmonary coronary arterial course, stenosis or atrophy of the coronary ostium, intramural coronary arterial course, abnormal number of coronary ostia, malposition of the coronary ostium

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.