Coronary artery congenital malformation

Summary

Coronary artery congenital malformation (MONDO:0015203) is a disease (an umbrella term covering 9 Mondo subtypes) and 4 clinical trials. A subtype of coronary artery disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 9 Mondo subtypes
• Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	coronary artery congenital malformation
Mondo ID	MONDO:0015203
Orphanet	1081
DOID	DOID:11843
ICD-11	902783759
SNOMED CT	28574005
UMLS	C4531298
MedGen	1612789
GARD	0001534
MedDRA	10061060
Is cancer (heuristic)	no

Also known as: congenital anomaly of coronary artery · congenital coronary artery anomaly · coronary artery abnormality [ambiguous] · coronary artery anomaly · coronary artery anomaly, congenital

Disease family

This is a subtype of coronary artery disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › arterial disorder › coronary artery disorder › coronary artery congenital malformation

Related subtypes (11): coronary vasospasm, postoperative ventricular dysfunction, coronary aneurysm, coronary stenosis, coronary thrombosis, intermediate coronary syndrome, coronary artery disease, autosomal dominant, 1, coronary artery disease, autosomal dominant 2, coronary atherosclerosis, nonobstructive coronary artery disease, fibromuscular dysplasia of the coronary arteries

Subtypes (9): anomalous left coronary artery from the pulmonary artery, coronary arterial fistulas, congenital coronary artery aneurysm, coronary artery intramyocardial course, aortopulmonary coronary arterial course, stenosis or atrophy of the coronary ostium, intramural coronary arterial course, abnormal number of coronary ostia, malposition of the coronary ostium

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06089902	Not specified	RECRUITING	European Prospective Registry on Anomalous Aortic Origin of the Coronary Arteries
NCT03194763	Not specified	COMPLETED	Observational Study for Feasibility and Performance of Sub-millisievert Coronary Computed Tomography Angiography (CCTA) for Coronary Artery Anomalies (CAA) in Paediatric Patients
NCT04224090	Not specified	COMPLETED	Diagnostic Performance of a New Method for the Echocardiographic Assessment of Coronary Arteries Abnormalities
NCT04830787	Not specified	COMPLETED	Correlation Between Myocardial Deformation and Coronary Artery Tortuosity in Patients With Hypertrophic Cardiomyopathy