Coronary microvascular disorder
diseaseOn this page
Also known as CMDcoronary microvascular diseaseheart disease of microvascular endotheliummicrovascular endothelium heart disease
Summary
Coronary microvascular disorder (MONDO:0044875) is a disease and 42 clinical trials. Top therapeutic interventions include adenosine, bivalirudin, and lufenuron. A subtype of heart disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 42
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | coronary microvascular disorder |
| Mondo ID | MONDO:0044875 |
| ICD-11 | 1752457658 |
| NCIT | C84478 |
| UMLS | C0206064 |
| MedGen | 104771 |
| Anatomy (UBERON) | UBERON:0008339 |
| Is cancer (heuristic) | no |
Also known as: CMD · coronary microvascular disease · heart disease of microvascular endothelium · microvascular endothelium heart disease
Disease family
This is a subtype of heart disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › heart disorder › coronary microvascular disorder
Related subtypes (33): endocardium disorder, pericardium disorder, cardiac tuberculosis, heart conduction disease, hypertensive heart disease, heart valve disorder, cardiomyopathy, coronary artery disorder, heart failure, congenital heart disease, heart aneurysm, rheumatic heart disease, cardiac rhythm disease, white forelock with malformations, atrioventricular defect-blepharophimosis-radial and anal defect syndrome, microcephaly-cardiac defect-lung malsegmentation syndrome, PHACE syndrome, microcephaly-facio-cardio-skeletal syndrome, Hadziselimovic type, cardiac anomalies-heterotaxy syndrome, polyvalvular heart disease syndrome, Thomas syndrome, 22q11.2 deletion syndrome, myocardial rupture, heart neoplasm, aortopulmonary window, cor biloculare, inflammation of heart layer, myocardial disorder, carcinoid heart disease, omphalocele-diaphragmatic hernia-cardiovascular anomalies-radial ray defect syndrome, cardiac ventricle disorder, cardiogenetic disease, cardiogenic shock
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 42.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 35 |
| PHASE4 | 4 |
| PHASE2/PHASE3 | 1 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06699420 | PHASE4 | RECRUITING | Qishenyiqi Dripping Pill for Coronary Microvascular Disease |
| NCT06901570 | PHASE4 | NOT_YET_RECRUITING | Clinical Evaluation of Aromatic Wentong in the Treatment of Coronary Microvascular Disease |
| NCT04202172 | PHASE4 | COMPLETED | Functional Assessment of the Infart-related Artery With Bioactive and Polymer-free Coronary Stents (The FUNCOMBO Trial) |
| NCT04220372 | PHASE4 | UNKNOWN | Tongxinluo Capsule for Coronary Microvascular Disease |
| NCT04218916 | PHASE2/PHASE3 | UNKNOWN | Rhodiola Rosea for Coronary Microvascular Disease |
| NCT04614467 | PHASE2 | TERMINATED | A Placebo-Controlled Trial of CLBS16 in Subjects With Coronary Microvascular Dysfunction |
| NCT06600178 | PHASE1 | RECRUITING | Study Targeting Myocardial Perfusion and Symptom Relief in Women With SGLT2 Inhibitors (STRONG) |
| NCT03537586 | Not specified | ACTIVE_NOT_RECRUITING | A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction |
| NCT04440761 | Not specified | RECRUITING | Barts-MINOCA Registry |
| NCT04606459 | Not specified | RECRUITING | COSIMA: COronary SInus Reducer for the Treatment of Refractory Microvascular Angina |
| NCT05178914 | Not specified | RECRUITING | Personalized Medicine Using Coronary Microvascular Function Measured in Patient With Percutaneous Coronary Intervention in Angina |
| NCT05369182 | Not specified | ACTIVE_NOT_RECRUITING | Multicenter Registry of Coronary Flow-Derived Indexes for Coronary Microvascular Disease (Multicenter FLOW-CMD Registry) |
| NCT05743140 | Not specified | RECRUITING | A Clinical Study of Fundus OCTA for the Identification of CMD |
| NCT05793567 | Not specified | NOT_YET_RECRUITING | A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI) |
| NCT05805462 | Not specified | ACTIVE_NOT_RECRUITING | The Euro-CRAFT Registry |
| NCT05810051 | Not specified | ACTIVE_NOT_RECRUITING | Exercise and Coronary Microvascular Disease |
| NCT05841199 | Not specified | RECRUITING | Coronary Flow During Rapid Heart Rates |
| NCT05913999 | Not specified | ENROLLING_BY_INVITATION | Serial PET MPI in Patients Undergoing Cancer Treatment |
| NCT06125392 | Not specified | RECRUITING | Multicenter Registry on Microvascular Dysfunction - Searching a New Ach Spasm Definition |
| NCT06529848 | Not specified | RECRUITING | Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study |
| NCT06597851 | Not specified | RECRUITING | Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease |
| NCT06676137 | Not specified | RECRUITING | An Observational Study of Coronary Microvascular Disease of China |
| NCT06898541 | Not specified | ENROLLING_BY_INVITATION | Coronary Sinus Reducer in Coronary Microvascular Disease |
| NCT06991322 | Not specified | RECRUITING | Self-Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD) (SERRA-I Study) |
| NCT02045459 | Not specified | COMPLETED | Microvascular Disease Exercise Trial |
| NCT02910154 | Not specified | COMPLETED | Comprehensive Treatment of Angina in Women With Microvascular Dysfunction |
| NCT03064295 | Not specified | UNKNOWN | Whole-Heart Myocardial Blood Flow Quantification Using MRI |
| NCT03104062 | Not specified | COMPLETED | Effect of Ticagrelor and Clopidogrel on Coronary Microcirculation in Patients With Acute Myocardial Infarction |
| NCT03523624 | Not specified | COMPLETED | Factor XIII and Other Biomarkers in ST Segment Elevation Myocardial Infarction |
| NCT03917251 | Not specified | WITHDRAWN | The Effects of Trans Venous Cardiac Pacing on Coronary Microvascular Function and Hemodynamics |
| NCT04005963 | Not specified | UNKNOWN | The Value of PET Quantitative Analysis of Coronary Physiology in Coronary Microvascular Disease |
| NCT04186676 | Not specified | COMPLETED | Myocardial Infarction With Non-Obstructive Coronary Arteries in the Greek Population |
| NCT04321434 | Not specified | TERMINATED | Hyperoxia and Microvascular Dysfunction |
| NCT04554004 | Not specified | COMPLETED | A Non-invasive Index of Microciculatory Resistance |
| NCT04598997 | Not specified | UNKNOWN | Artificial Intelligence With DEep Learning on COROnary Microvascular Disease |
| NCT04685941 | Not specified | COMPLETED | Treatment of Slow-flow After Primary Percutaneous Coronary Intervention With Flow-mediated Hyperemia |
| NCT04960371 | Not specified | UNKNOWN | Effects of Anxiety on Coronary Microcirculatory Function in Hypertensive Patients |
| NCT05346458 | Not specified | COMPLETED | Measuring Blood Flow in Heart Vessels With a New Fibre Optic Sensor |
| NCT05471739 | Not specified | COMPLETED | Simultaneous Assessment of Coronary Microvascular Dysfunction and Ischemia With Non-obstructed Coronary Arteries With Intracoronary Electrocardiogram and Intracoronary Doppler |
| NCT05825339 | Not specified | UNKNOWN | Absolute Flow for Ischemia With No Obstructive Coronary Arteries |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ADENOSINE | 4 | 1 |
| BIVALIRUDIN | 4 | 1 |
| LUFENURON | 2 | 1 |
| CHEMBL606298 | 0 | 1 |
Related Atlas pages
- Drugs: Adenosine, Bivalirudin