Cortical cataract

Summary

Cortical cataract (MONDO:0045051) is a disease and 5 clinical trials. A subtype of cataract — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 5

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	cortical cataract
Mondo ID	MONDO:0045051
ICD-11	1118806999
NCIT	C135177
SNOMED CT	193576003
UMLS	C0271160
MedGen	82868
Anatomy (UBERON)	UBERON:0000389
Is cancer (heuristic)	no

Also known as: cataract (disease) of lens cortex · lens cortex cataract (disease)

Disease family

This is a subtype of cataract. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › lens disorder › cataract › cortical cataract

Related subtypes (28): immature cataract, diabetic cataract, mature cataract, tetanic cataract, myotonic cataract, senile cataract, diabetes mellitus type 2 associated cataract, cataract 4 multiple types, cataract 29, cataract 1 multiple types, early-onset non-syndromic cataract, cataract 3 multiple types, cataract 9 multiple types, cataract 28, cataract 18, cataract 12 multiple types, cataract 34 multiple types, cataract 36, bhaskar jagannathan syndrome, autosomal dominant cataract, craniostenosis cataract, Kozlowski Rafinski Klicharska syndrome, cataract 49, cataract 48, hypermature cataract, nuclear cataract, cataract 2, multiple types, cataract 50 with or without glaucoma

Subtypes (1): cortical senile cataract

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	5

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01878838	Not specified	COMPLETED	The Comparison of Cataract Lasers Using the Optimedica Catalys Laser and the Alcon LenSx Laser.
NCT03324295	Not specified	UNKNOWN	Aqueous Urea Concentration May be Related to Cataract Development
NCT03819842	Not specified	COMPLETED	Evaluating the Need for the Pseudophakic Intraoperative Abberrometry in Toric IOL Implantation
NCT04975971	Not specified	COMPLETED	A Retrospective Review of DEXTENZA 0.4 mg inseRt Following Corneal Transplant or Cataract Surgery
NCT06660849	Not specified	COMPLETED	Atrial Fibrillation Duration and Cortical Lens Opacity