Cough variant asthma

Summary

Cough variant asthma (MONDO:0001491) is a disease and 13 clinical trials. Top therapeutic interventions include arformoterol, budesonide, and formoterol. A subtype of asthma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 13

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	cough variant asthma
Mondo ID	MONDO:0001491
DOID	DOID:12323
ICD-10-CM	J45.991
ICD-11	1466639844
SNOMED CT	409663006
UMLS	C0694548
MedGen	675053
Is cancer (heuristic)	no

Disease family

This is a subtype of asthma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › bronchial disorder › asthma › cough variant asthma

Related subtypes (7): intrinsic asthma, status asthmaticus, allergic asthma, childhood onset asthma, occupational asthma, chronic asthma, acute asthma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 13.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	7
PHASE4	5
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03105843	PHASE4	RECRUITING	Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
NCT01170429	PHASE4	UNKNOWN	Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA)
NCT02002754	PHASE4	UNKNOWN	The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma
NCT04171180	PHASE4	UNKNOWN	The Efficacy of Budesonide/Formoterol in Cough Variant Asthma
NCT06590740	PHASE4	COMPLETED	Establish FeNO Cut-off Value for Predicting Budesonide-formoterol Response in Chronic Cough Suggestive of CVA Patients.
NCT03319043	PHASE1/PHASE2	UNKNOWN	Observation of Cough Variant Asthma Treated in Combination of Chanqin Granules.
NCT00660114	Not specified	COMPLETED	Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Children Outpatients
NCT01064245	Not specified	COMPLETED	Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests
NCT03169699	Not specified	UNKNOWN	Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data
NCT03363698	Not specified	COMPLETED	MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough
NCT03573284	Not specified	COMPLETED	Validity of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma
NCT04203472	Not specified	COMPLETED	Optimal Type of Inhaler in Cough Variant- or Cough Predominant Asthma
NCT05459805	Not specified	UNKNOWN	Multicenter Clinical Study on the Optimal Treatment Protocol and Outcome of Cough Variant Asthma With Chinese and Western Medicine

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ARFORMOTEROL	4	1
BUDESONIDE	4	1
FORMOTEROL	4	1
PROCATEROL	3	3
CHEMBL1603534	0	1
CHEMBL249466	0	1