Cranial neuralgia

Summary

Cranial neuralgia (MONDO:0016374) is a disease and 2 clinical trials. Top therapeutic interventions include dextromethorphan. A subtype of cranial nerve neuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	cranial neuralgia
Mondo ID	MONDO:0016374
Orphanet	221109
SNOMED CT	23096007
UMLS	C0010269
MedGen	507603
GARD	0020542
Anatomy (UBERON)	UBERON:0034713
Is cancer (heuristic)	no

Also known as: cranial neuron projection bundle neuralgia · facial neuralgia · neuralgia of cranial neuron projection bundle

Disease family

This is a subtype of cranial nerve neuropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › cranial nerve neuropathy › cranial neuralgia

Related subtypes (16): vestibulocochlear nerve disorder, ocular motility disease, hypoglossal nerve disorder, facial nerve disorder, optic nerve disorder, cranial nerve neoplasm, accessory nerve disorder, glossopharyngeal nerve disorder, olfactory nerve disorder, cranial nerve palsy, trigeminal nerve disorder, third cranial nerve disorder, pseudobulbar palsy, trochlear nerve disorder, jaw-winking syndrome, abducens nerve disorder

Subtypes (4): facial neuralgia, trigeminal neuralgia, combined hyperactive dysfunction syndrome of the cranial nerves, glossopharyngeal neuralgia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00001725	PHASE2	COMPLETED	Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain
NCT01932255	Not specified	WITHDRAWN	CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DEXTROMETHORPHAN	4	3