Croup

disease

On this page

Also known as acute laryngotracheobronchitisacute obstructive laryngitis

Summary

Croup (MONDO:0005722) is a disease and 17 clinical trials. Top therapeutic interventions include betamethasone, dexamethasone, and olive oil. A subtype of laryngotracheitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

Clinical trials: 17

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	croup
Mondo ID	MONDO:0005722
EFO	EFO:0007227
MeSH	D003440
DOID	DOID:9395
ICD-10-CM	J05.0
NCIT	C26735
SNOMED CT	71186008
UMLS	C0010380
MedGen	3668
Is cancer (heuristic)	no

Also known as: acute laryngotracheobronchitis · acute obstructive laryngitis

Disease family

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › upper respiratory tract disorder › laryngeal disorder › laryngitis › laryngotracheitis › croup

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 3 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Beclomethasone Dipropionate	Phase 3 (in late-stage trials)
Fluticasone	Phase 3 (in late-stage trials)
Prednisolone	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 17.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	7
PHASE3	6
PHASE4	3
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01042145	PHASE4	COMPLETED	Community Care for Croup (RCT)
NCT01664507	PHASE4	UNKNOWN	The Effect and Safety of Low Dose Nebulized Epinephrine in Croup
NCT03705273	PHASE4	TERMINATED	Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup
NCT06560255	PHASE3	RECRUITING	Fish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma
NCT06570889	PHASE3	RECRUITING	VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma
NCT00368823	PHASE3	COMPLETED	A Trial of Point of Care Information in Ambulatory Pediatrics
NCT00938353	PHASE3	TERMINATED	Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup
NCT01748162	PHASE3	TERMINATED	Management of Recurrent Croup
NCT06272383	PHASE3	COMPLETED	Croup Dosing Study
NCT00230841	PHASE2	COMPLETED	Comparing Different Ways of Delivering Humidity to Children With Croup
NCT00147849	Not specified	TERMINATED	A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup
NCT02973282	Not specified	COMPLETED	Diagnosing Respiratory Disease in Children Using Cough Sounds
NCT03392363	Not specified	COMPLETED	Diagnosing Respiratory Disease in Children Using Cough Sounds 2
NCT04168554	Not specified	UNKNOWN	Telemedicine in the Generals Practitioners Office
NCT05668364	Not specified	COMPLETED	Impact of Cold Air Exposure on Croup Symptoms
NCT06156436	Not specified	COMPLETED	A Study Evaluating the Use of ResAppDx v2.0 as an Aid to Diagnose Respiratory Disease in Paediatric Patients in an Emergency Department
NCT06959407	Not specified	COMPLETED	Efficacy Of Oral Dexamethasone Versus Parenteral Dexamethasone In The Management Of Mild To Moderate Croup

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BETAMETHASONE	4	1
DEXAMETHASONE	4	1
OLIVE OIL	4	1
PREDNISONE	4	1
FLUTICASONE	3	1
CHEMBL15720	0	1

Drugs: Betamethasone, Dexamethasone, Olive Oil, Prednisone, Fluticasone