Cutaneous leukocytoclastic angiitis
diseaseOn this page
Also known as cutaneous hypersensitivity vasculitiscutaneous leukocytoclastic vasculitiscutaneous small vessel vasculitiscutaneous small-vessel vasculitishypersensitivity angiitisleukocytoclastic angiitis
Summary
Cutaneous leukocytoclastic angiitis (MONDO:0019509) is a disease. A subtype of immune complex mediated vasculitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-9 / 100 000 (Norway) [Orphanet-validated]
- Phenotypes (HPO): 14
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 2.7 | Norway | Validated |
Signs & symptoms
Clinical features (HPO)
14 HPO clinical features (Orphanet curated; top 14 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000965 | Cutis marmorata | Very frequent (80-99%) |
| HP:0000979 | Purpura | Very frequent (80-99%) |
| HP:0001025 | Urticaria | Very frequent (80-99%) |
| HP:0001581 | Recurrent skin infections | Very frequent (80-99%) |
| HP:0001945 | Fever | Very frequent (80-99%) |
| HP:0002633 | Vasculitis | Very frequent (80-99%) |
| HP:0003326 | Myalgia | Very frequent (80-99%) |
| HP:0010783 | Erythema | Very frequent (80-99%) |
| HP:0100758 | Gangrene | Very frequent (80-99%) |
| HP:0200034 | Papule | Very frequent (80-99%) |
| HP:0000988 | Skin rash | Frequent (30-79%) |
| HP:0002829 | Arthralgia | Frequent (30-79%) |
| HP:0000163 | Abnormal oral cavity morphology | Occasional (5-29%) |
| HP:0001482 | Subcutaneous nodule | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | cutaneous leukocytoclastic angiitis |
| Mondo ID | MONDO:0019509 |
| Orphanet | 889 |
| ICD-11 | 247535295, 71458216 |
| NCIT | C122919 |
| SNOMED CT | 718217000 |
| UMLS | C4049638 |
| MedGen | 881641 |
| GARD | 0007851 |
| Is cancer (heuristic) | no |
Also known as: cutaneous hypersensitivity vasculitis · cutaneous leukocytoclastic vasculitis · cutaneous small vessel vasculitis · cutaneous small-vessel vasculitis · hypersensitivity angiitis · leukocytoclastic angiitis
Disease family
This is a subtype of immune complex mediated vasculitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › vasculitis › immune complex mediated vasculitis › cutaneous leukocytoclastic angiitis
Related subtypes (4): Cryoglobulinemic vasculitis, hypocomplementemic urticarial vasculitis, immunoglobulin A vasculitis, erythema elevatum diutinum
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.