Cystic echinococcosis

Summary

Cystic echinococcosis (MONDO:0018408) is a disease and 5 clinical trials. A subtype of echinococcus granulosus infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 41
• Clinical trials: 5

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	1-9 / 100 000	1	Europe	Validated

Signs & symptoms

Clinical features (HPO)

41 HPO clinical features (Orphanet curated; top 41 by frequency):

HPO ID	Term	Frequency
HP:0001407	Hepatic cysts	Very frequent (80-99%)
HP:0001880	Eosinophilia	Very frequent (80-99%)
HP:0001824	Weight loss	Frequent (30-79%)
HP:0002611	Cholestatic liver disease	Frequent (30-79%)
HP:0010702	Increased circulating antibody level	Frequent (30-79%)
HP:0012378	Fatigue	Frequent (30-79%)
HP:0410019	Epigastric pain	Frequent (30-79%)
HP:0000775	Abnormality of the diaphragm	Occasional (5-29%)
HP:0002240	Hepatomegaly	Occasional (5-29%)
HP:0002904	Hyperbilirubinemia	Occasional (5-29%)
HP:0002910	Elevated circulating hepatic transaminase concentration	Occasional (5-29%)
HP:0003155	Elevated circulating alkaline phosphatase concentration	Occasional (5-29%)
HP:0005230	Biliary tract obstruction	Occasional (5-29%)
HP:0005948	Multiple pulmonary cysts	Occasional (5-29%)
HP:0011458	Abdominal symptom	Occasional (5-29%)
HP:0025615	Abscess	Occasional (5-29%)
HP:0030948	Elevated gamma-glutamyltransferase level	Occasional (5-29%)
HP:0031983	Abnormal pulmonary thoracic imaging finding	Occasional (5-29%)
HP:0032101	Unusual infection	Occasional (5-29%)
HP:0032445	Pulmonary cyst	Occasional (5-29%)
HP:0100845	Anaphylactic shock	Occasional (5-29%)
HP:0000107	Renal cyst	Very rare (<1-4%)
HP:0000138	Ovarian cyst	Very rare (<1-4%)
HP:0000478	Abnormality of the eye	Very rare (<1-4%)
HP:0000925	Abnormality of the vertebral column	Very rare (<1-4%)
HP:0000952	Jaundice	Very rare (<1-4%)
HP:0001025	Urticaria	Very rare (<1-4%)
HP:0001627	Abnormal heart morphology	Very rare (<1-4%)
HP:0001732	Abnormality of the pancreas	Very rare (<1-4%)
HP:0002099	Asthma	Very rare (<1-4%)
HP:0002585	Abnormality of the peritoneum	Very rare (<1-4%)
HP:0003011	Abnormality of the musculature	Very rare (<1-4%)
HP:0010576	Intracranial cystic lesion	Very rare (<1-4%)
HP:0011355	Localized skin lesion	Very rare (<1-4%)
HP:0012062	Bone cyst	Very rare (<1-4%)
HP:0012578	Membranous nephropathy	Very rare (<1-4%)
HP:0030423	Splenic cyst	Very rare (<1-4%)
HP:0031630	Abnormal subpleural morphology	Very rare (<1-4%)
HP:0031700	Invasive parasitic infection	Very rare (<1-4%)
HP:0045058	Abnormality of the testis size	Very rare (<1-4%)
HP:0100592	Peritoneal abscess	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	cystic echinococcosis
Mondo ID	MONDO:0018408
Orphanet	400
DOID	DOID:1495
SNOMED CT	721822004
UMLS	C4553297
MedGen	1639841
GARD	0002764
MedDRA	10014096
Is cancer (heuristic)	no

Also known as: hydatid disease · Hydatidosis

Disease family

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › parasitic infectious disease › helminthiasis › Cestode infectious disease › echinococcosis › echinococcus granulosus infectious disease › cystic echinococcosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	5

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07333612	Not specified	RECRUITING	IM Bands in Inactive Hepatic CE
NCT03289884	Not specified	UNKNOWN	MR Assessment of Hepatic Hydatid Disease
NCT05113550	Not specified	COMPLETED	Surgical Treatment of Hepatic Hydatidosis in Elderly Patients
NCT05769790	Not specified	UNKNOWN	Droplet-digital PCR for the Detection of Circulating Cell-free DNA in Patients With Cystic Echinococcosis: an Exploratory Study
NCT06289816	Not specified	COMPLETED	Spleen Preserving Surgery for Splenic Hydatidosis: A Cohort Study on Short and Long-Term Outcomes