Cytomegalovirus retinitis
diseaseOn this page
Also known as Cytomegaloviral RetinitisCytomegalovirus caused retinitisRetinitis, Cytomegaloviral
Summary
Cytomegalovirus retinitis (MONDO:0000878) is a disease and 62 clinical trials. Top therapeutic interventions include foscarnet, ganciclovir, and cidofovir anhydrous. A subtype of retinitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 62
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | cytomegalovirus retinitis |
| Mondo ID | MONDO:0000878 |
| EFO | EFO:1001302 |
| MeSH | D017726 |
| DOID | DOID:0080160 |
| ICD-11 | 315493536 |
| NCIT | C50521 |
| SNOMED CT | 22455005 |
| UMLS | C0206178 |
| MedGen | 61532 |
| GARD | 0009531 |
| Is cancer (heuristic) | no |
Also known as: Cytomegaloviral Retinitis · Cytomegalovirus caused retinitis · Cytomegalovirus retinitis · cytomegalovirus retinitis · Retinitis, Cytomegaloviral
Disease family
This is a subtype of retinitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › retinal disorder › retinitis › cytomegalovirus retinitis
Related subtypes (4): histoplasmosis retinitis, acute retinal necrosis syndrome, optic papillitis, retinal vasculitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
2 approved, 3 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Fomivirsen | Approved (phase 4) |
| Ganciclovir | Approved (phase 4) |
| Foscarnet | Phase 3 (in late-stage trials) |
| Sargramostim | Phase 3 (in late-stage trials) |
| Valganciclovir | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Fomivirsen Sodium.
Clinical trials & evidence
Clinical trials
Clinical trials: 62.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 29 |
| PHASE2 | 11 |
| PHASE3 | 9 |
| PHASE1 | 8 |
| PHASE4 | 3 |
| PHASE2/PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00000894 | PHASE4 | COMPLETED | Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis |
| NCT00002125 | PHASE4 | COMPLETED | A Multicenter Study of Oral Versus Intravenous Hydration in AIDS Patients With CMV Retinitis Treated With Foscavir (Foscarnet Sodium) |
| NCT01866397 | PHASE4 | COMPLETED | Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration |
| NCT00000118 | PHASE3 | COMPLETED | Ganciclovir Implant Study for Cytomegalovirus Retinitis |
| NCT00000134 | PHASE3 | COMPLETED | Studies of the Ocular Complications of AIDS (SOCA)–Cytomegalovirus Retinitis Retreatment Trial (CRRT) |
| NCT00000135 | PHASE2/PHASE3 | COMPLETED | Studies of the Ocular Complications of AIDS (SOCA)–Monoclonal Antibody CMV Retinitis Trial (MACRT) |
| NCT00000136 | PHASE3 | COMPLETED | Studies of the Ocular Complications of AIDS (SOCA)–Foscarnet-Ganciclovir CMV Retinitis Trial (FGCRT) |
| NCT00000143 | PHASE3 | COMPLETED | Studies of Ocular Complications of AIDS (SOCA)–Ganciclovir-Cidofovir CMV Retinitis Trial (GCCRT) |
| NCT00000688 | PHASE3 | COMPLETED | A Randomized, Controlled Study of Intravenous Ganciclovir Therapy for Peripheral Cytomegalovirus Retinitis in Patients With AIDS |
| NCT00000698 | PHASE3 | COMPLETED | A Treatment Protocol for the Use of Intravenous Ganciclovir in AIDS Patients With Immediately Sight-Threatening CMV Retinitis |
| NCT00002070 | PHASE3 | COMPLETED | Phase III Ganciclovir +/- rGM-CSF for AIDS-Related CMV Retinitis |
| NCT00002377 | PHASE3 | COMPLETED | A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes |
| NCT00017784 | PHASE3 | UNKNOWN | Valganciclovir in Patients With CMV Retinitis and AIDS Who Cannot Take Drugs by Injection |
| NCT00000691 | PHASE2 | COMPLETED | A Phase II Dose-Ranging, Open-Labelled Trial of Foscarnet Salvage Therapy for AIDS Patients With Sight-Threatening CMV Retinitis Who Cannot Be Treated With Ganciclovir Due To Myelosuppression or Treatment Failure |
| NCT00000697 | PHASE2 | WITHDRAWN | A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Cannot Use Ganciclovir |
| NCT00000766 | PHASE2 | COMPLETED | CMV Retinitis Retreatment Trial |
| NCT00000836 | PHASE2 | COMPLETED | A Phase II/III Trial of Human Anti-CMV Monoclonal Antibody MSL 109 (MACRT) |
| NCT00001034 | PHASE2 | COMPLETED | The Safety and Effectiveness of Ganciclovir in the Prevention of Cytomegalovirus (CMV) of the Eyes and Disease of the Stomach and Intestines in Patients With HIV |
| NCT00001061 | PHASE2 | COMPLETED | Comparison of Two Methods in the Treatment of Cytomegalovirus of the Eyes in Patients With AIDS |
| NCT00002156 | PHASE2 | COMPLETED | A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR ) |
| NCT00002169 | PHASE2 | COMPLETED | A Study of Viracept in AIDS Patients With Cytomegalovirus Retinitis |
| NCT00002356 | PHASE2 | COMPLETED | The Safety and Effectiveness of ISIS 2922 in Patients With AIDS Who Have Cytomegalovirus (CMV) of the Eyes |
| NCT00002437 | PHASE2 | COMPLETED | The Safety and Effectiveness of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS |
| NCT00004794 | PHASE2 | COMPLETED | Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus Retinitis |
| NCT00000668 | PHASE1 | COMPLETED | A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral Ganciclovir |
| NCT00000673 | PHASE1 | COMPLETED | A Phase I/II Open-Labelled Trial of Intravitreal Ganciclovir Salvage Therapy for AIDS Patients With Active CMV Retinitis Who Are Intolerant of Systemic Therapy |
| NCT00000726 | PHASE1 | COMPLETED | Foscarnet Treatment of Serious CMV Retinitis Infection in Patients With Acquired Immunodeficiency Syndrome |
| NCT00000881 | PHASE1 | WITHDRAWN | A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease |
| NCT00000970 | PHASE1 | COMPLETED | A Study of Foscarnet Plus Ganciclovir in the Treatment of Cytomegalovirus of the Eye in Patients With AIDS Who Have Already Been Treated With Ganciclovir |
| NCT00001062 | PHASE1 | COMPLETED | A Study of Ganciclovir in the Treatment of Cytomegalovirus of the Eyes |
| NCT00002016 | PHASE1 | COMPLETED | A Phase I/II Trial to Assess the Safety and Tolerance of Escalating Doses of a Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Retinitis |
| NCT00002321 | PHASE1 | COMPLETED | A Phase I Study of the Safety of Proleukin (Aldesleukin) in Combination With Ganciclovir and Antiretroviral Therapy in HIV Seropositive Patients With Cytomegalovirus (CMV) Retinitis |
| NCT05911503 | EARLY_PHASE1 | RECRUITING | Clinical Study of High Concentration Ganciclovir Eye Drops in the Treatment of Cytomegalovirus Retinitis |
| NCT00000168 | Not specified | COMPLETED | Longitudinal Study of Ocular Complications of AIDS (LSOCA) |
| NCT00000665 | Not specified | COMPLETED | Studies of the Ocular Complications of AIDS (SOCA) CMV Retinitis Trial: Foscarnet-Ganciclovir Component |
| NCT00000693 | Not specified | COMPLETED | Suppression of Cytomegalovirus Retinitis Utilizing High Dose Intravenous Acyclovir and Oral Zidovudine in Patients With AIDS |
| NCT00000799 | Not specified | COMPLETED | HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol |
| NCT00000905 | Not specified | COMPLETED | A Study to Evaluate the Effects of Stopping Maintenance Therapy for Cytomegalovirus (CMV) Retinitis After Effective Anti-HIV Therapy |
| NCT00000989 | Not specified | COMPLETED | The Safety and Effectiveness of Ganciclovir Used Alone or in Combination With Granulocyte-Macrophage Colony Stimulating Factor in the Treatment of Cytomegalovirus (CMV) of the Eye in Patients With AIDS |
| NCT00001611 | Not specified | COMPLETED | Immune Activity Against CVM Retinitis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| FOSCARNET | 4 | 48 |
| GANCICLOVIR | 4 | 28 |
| CIDOFOVIR ANHYDROUS | 4 | 18 |
| PROBENECID | 4 | 5 |
| FOMIVIRSEN SODIUM | 4 | 4 |
| VALGANCICLOVIR | 4 | 3 |
| SARGRAMOSTIM | 4 | 2 |
| ACYCLOVIR | 4 | 1 |
| HUMAN IMMUNOGLOBULIN G | 4 | 1 |
| INTERFERON BETA-1B | 4 | 1 |
| NELFINAVIR MESYLATE | 4 | 1 |
| SEVIRUMAB | 2 | 4 |
| CHEMBL365442 | 0 | 1 |