Dacryocystitis

Summary

Dacryocystitis (MONDO:0004926) is a disease and 12 clinical trials. Top therapeutic interventions include proparacaine and pregabalin. A subtype of inflammatory disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 12

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	dacryocystitis
Mondo ID	MONDO:0004926
MeSH	D003607
DOID	DOID:9938
ICD-11	1034960983
NCIT	C34521
SNOMED CT	85777005
UMLS	C0010930
MedGen	3686
Is cancer (heuristic)	no

Also known as: Dacryoadenitides · dacryoadenitis · Dacryocystitides · inflammation of lacrimal sac · lacrimal sac inflammation

Disease family

This is a subtype of inflammatory disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › inflammatory disease › dacryocystitis

Related subtypes (93): chorioamnionitis, pyometritis, uvulitis, mastoiditis, pelvic inflammatory disease, tonsillitis, nasopharyngitis, petrositis, nephritis, esophagitis, geniculate ganglionitis, epicondylitis, labyrinthitis, lymphadenitis, cheilitis, neuritis, vaginitis, hepatitis, pharyngitis, hidradenitis, gastroenteritis, dermatitis, bursitis, laryngitis, keratitis, endocervicitis, conjunctivitis, spondylitis, thyroiditis, diverticulitis, neuronitis, mediastinitis, epididymitis, blepharitis, cholangitis, dacryoadenitis, fasciitis, chronic inflammation of lacrimal passage, periostitis, gastritis, pancreatitis, periodontitis, encephalomyelitis, placental villitis, prostatitis, urethritis, otitis media, perianal Crohn disease, proctitis, arthritic joint disease, oral tuberculosis, parotitis, pericarditis, sinusitis, cystitis, panniculitis, balanitis, chronic inflammatory demyelinating polyradiculoneuropathy, glossitis, mastitis, oophoritis, orchitis, perinephritis, pulpitis, rheumatic heart disease, vulvitis, thromboangiitis obliterans, STING-associated vasculopathy with onset in infancy, endophthalmitis, chronic granulomatous disease, IgG4-related pachymeningitis, vasculitis, chronic pneumonitis of infancy, uveitis, mucositis, amnionitis, diaphragmitis, gonococcal cervicitis, posthitis, myositis disease, omphalitis, ear infection, radiculitis, tracheobronchitis, ureteritis, enthesitis, inflammation of heart layer, serositis, pneumonitis, immune reconstitution inflammatory syndrome, multiple evanescent white dot syndrome, isolated anogenital granulomatosis, myelin oligodendrocyte glycoprotein antibody-associated disease

Subtypes (4): acute dacryocystitis, phlegmonous dacryocystitis, chronic dacryocystitis, neonatal dacryocystitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 12.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	9
PHASE4	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05663684	PHASE4	RECRUITING	Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain?
NCT07504250	PHASE4	NOT_YET_RECRUITING	Hyaluronic Acid vs Mitomycin-C in External Dacryocystorhinostomy
NCT04229771	PHASE4	TERMINATED	Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?
NCT07135570	Not specified	RECRUITING	My Eyes, My Light: Amar Chokh, Amar Alo
NCT00008541	Not specified	COMPLETED	Evaluation and Treatment of Patients With Corneal and External Diseases
NCT00349297	Not specified	COMPLETED	The Microbiological Spectrum in Acute Dacryocystitis
NCT00706251	Not specified	COMPLETED	Follow up of Nasolacrimal Intubation in Adults
NCT01772277	Not specified	COMPLETED	Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis
NCT03216642	Not specified	UNKNOWN	The Study of Bacteriology and Pathogen Drug Sensitivity of Chronic Dacryocystitis
NCT04833452	Not specified	UNKNOWN	Comparative Study Between Wide and Narrow Fenstrum Endoscopic DCR
NCT05455944	Not specified	COMPLETED	Analgesic Efficacy of Pre-operative Oral Pregabalin in Dacryocystorhinostomy Surgery
NCT06810089	Not specified	COMPLETED	Examination of Lacrimal Sac and Nasal Mucosa Preparations Taken in Dacryocystorhinostomy Surgery of Patients With Nasolacrimal Duct Obstruction and Comparison of Clinical Groups With Each Other

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PROPARACAINE	4	2
PREGABALIN	4	1