de Quervain disease

Summary

de Quervain disease (MONDO:0006721) is a disease and 15 clinical trials. Top therapeutic interventions include acetaminophen, hydrocodone, and ibuprofen. A subtype of arthropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 15

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	de Quervain disease
Mondo ID	MONDO:0006721
EFO	EFO:1000891
MeSH	D053684
DOID	DOID:14107
ICD-10-CM	M65.4
SNOMED CT	21794005
UMLS	C0149870
MedGen	101771
Is cancer (heuristic)	no

Also known as: radial styloid tenosynovitis

Disease family

This is a subtype of arthropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › arthropathy › de Quervain disease

Related subtypes (23): transient arthropathy, synovial plica syndrome, hypermobility syndrome, Tietze syndrome, neurogenic arthropathy, Behcet syndrome arthropathy, ankylosis, bursitis, synovium neoplasm, hydrarthrosis, articular cartilage disorder, hemarthrosis, tenosynovitis, ganglion or cyst of synovium/tendon/bursa, spondyloarthropathy, temporomandibular joint disorder, arthritic joint disease, frozen shoulder, patellofemoral pain syndrome, secondary hypertrophic osteoarthropathy, shoulder impingement syndrome, crystal arthropathy, vertebral joint disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 15.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	12
PHASE4	2
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06012097	PHASE4	RECRUITING	Impact of Gel Aromatherapy on Pain for Patients With De Quervain Disease
NCT02029235	PHASE4	TERMINATED	Post-operative Analgesia in Elective, Soft-tissue Hand Surgery
NCT03111186	PHASE2	COMPLETED	Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery
NCT06296472	Not specified	RECRUITING	De Quervain’s Disease in the Acute Phase:a Study Aimed at Evaluating the Effectiveness of Standard Physiotherapy Treatment (HANDGUIDE), Compared to Experimental Treatment After Performing Ultrasound-guided Infiltrative Therapy.
NCT07158892	Not specified	NOT_YET_RECRUITING	Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test
NCT04069741	Not specified	TERMINATED	Treating Depression in Patients With De Quervain’s Tenosynovitis; An Integrated Web Based Skills Intervention
NCT04260984	Not specified	COMPLETED	Effect of Ultrasound-guided Corticosteroid Injection Versus Palpation-guided Injection for de Quervain’s Disease
NCT04384536	Not specified	COMPLETED	Evaluation of Effectiveness of Local Anesthetic Injection in Patients With De Quervain Tenosynovitis
NCT05141799	Not specified	COMPLETED	Effectiveness of High-intensity Laser Therapy in De Quervain Tenosynovitis
NCT05261737	Not specified	UNKNOWN	Steroid Injection in De Quervain Tenosynovitis
NCT05423223	Not specified	COMPLETED	Comparative Effects of Paraffin Bath Therapy and ESWT on Quality of Life and Sleep in De Quervain Tenosynovitis
NCT05423353	Not specified	COMPLETED	Comparative Effects of Paraffin Bath Therapy and ESWT in Patients With De Quervain Tenosynovitis
NCT05692583	Not specified	COMPLETED	Correlation Between EPB Entrapment Test and Ultrasound Wrist Findings in Patients With deQuervain’s Disease
NCT05782114	Not specified	UNKNOWN	Efficacy of Extracorporeal Shockwave Therapy on Ultrasonographic Changes in de Quervain Tenosynovitis
NCT06980779	Not specified	COMPLETED	The Correlation of Clinical and Ultrasonographic Findings in Dorsoradial Wrist Pain Patients: Cross Sectional Study

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ACETAMINOPHEN	4	2
HYDROCODONE	4	1
IBUPROFEN	4	1