Decompression sickness
disease diseaseOn this page
Also known as BendsCAISSON DISCaisson DiseaseCaisson DiseasesCompressed air diseaseCompressed-air diseaseDisease, CaissonDiseases, CaissonDivers' palsyDivers' paralysisRapture of the deep syndromeSickness, DecompressionThe bends
Summary
Decompression sickness (MONDO:0020797) is a disease and 14 clinical trials. Top therapeutic interventions include oxygen and air, medical. A subtype of high pressure neurological syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 14
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | decompression sickness |
| Mondo ID | MONDO:0020797 |
| MeSH | D003665 |
| SNOMED CT | 89684003 |
| UMLS | C0011119 |
| MedGen | 41434 |
| Is cancer (heuristic) | no |
Also known as: Bends · bends · CAISSON DIS · Caisson Disease · Caisson disease · Caisson Diseases · Compressed air disease · Compressed-air disease · decompression sickness · Disease, Caisson · Diseases, Caisson · Divers’ palsy · Divers’ paralysis · Rapture of the deep syndrome · Sickness, Decompression · The bends
Disease family
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › high pressure neurological syndrome › decompression sickness
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 14.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 11 |
| PHASE2/PHASE3 | 1 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02468752 | PHASE2/PHASE3 | COMPLETED | Reduction of Venous Emboli Load After Breathing Normobaric Oxygen Compared to Air |
| NCT06216366 | PHASE2 | ACTIVE_NOT_RECRUITING | Rhu-pGSN to Mitigate Proinflammatory Responses to Decompression in Healthy SCUBA Divers |
| NCT06740305 | PHASE1 | SUSPENDED | NASA Prebreathe Study |
| NCT04791488 | Not specified | RECRUITING | Impact of Hyperoxia and Involvement of the Immune System in Diving Accident |
| NCT06370897 | Not specified | NOT_YET_RECRUITING | Prediction & Mechanisms of Recovery Following IEDS |
| NCT06627153 | Not specified | NOT_YET_RECRUITING | Epidemiological Assessment of Technical Diving Accidents in Mainland France and Factors Predictive of Severity (TEKCare) |
| NCT01587209 | Not specified | COMPLETED | Microparticles in Scuba Divers With Decompression Sickness |
| NCT02064361 | Not specified | COMPLETED | High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation |
| NCT02118207 | Not specified | COMPLETED | Exercise and Repetitive Diving |
| NCT02432131 | Not specified | COMPLETED | Decompression Sickness in Divers With or Without Patent Foramen Ovale |
| NCT02483650 | Not specified | UNKNOWN | Hyperbaric Oxygen Therapy Registry |
| NCT02736006 | Not specified | COMPLETED | Decreases in Diffusing Lung Capacity for Carbon Monoxide (DLCO) in Occupational Divers and Their Impact on Decompression Sickness Risks |
| NCT03192956 | Not specified | UNKNOWN | Markers of Central Nervous System Injury in Decompression Sickness |
| NCT03390335 | Not specified | COMPLETED | Decompression Tables for Diving at Altitude |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| OXYGEN | 4 | 2 |
| CHEMBL1230914 | 0 | 1 |
| AIR, MEDICAL | -1 | 1 |
Related Atlas pages
- Drugs: Oxygen