Dental fluorosis
diseaseOn this page
Also known as fluorosismottled teethmottling of enamel
Summary
Dental fluorosis (MONDO:0006722) is a disease and 13 clinical trials. Top therapeutic interventions include water. A subtype of tooth disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 13
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | dental fluorosis |
| Mondo ID | MONDO:0006722 |
| EFO | EFO:1000892 |
| MeSH | D009050 |
| DOID | DOID:13711 |
| ICD-10-CM | K00.3 |
| NCIT | C85059 |
| SNOMED CT | 30265004 |
| UMLS | C0026618 |
| MedGen | 44506 |
| MedDRA | 10016819 |
| Is cancer (heuristic) | no |
Also known as: fluorosis · mottled teeth · mottling of enamel
Disease family
This is a subtype of tooth disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › tooth disorder › dental fluorosis
Related subtypes (10): dental abscess, tooth hard tissue disease, tooth erosion, non-bacterial, dental pulp disorder, tooth agenesis, anodontia, taurodontism, dentinogenesis imperfecta, odontogenic neoplasm, dental radicular dysplasia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 13.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 9 |
| PHASE1 | 3 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01049503 | PHASE3 | COMPLETED | Effect of pH and Fluoride Concentration of Dentifrices on Caries Control |
| NCT01571050 | PHASE1 | COMPLETED | Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as Abrasives |
| NCT01589991 | PHASE1 | COMPLETED | Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes |
| NCT01978041 | PHASE1 | COMPLETED | Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated Water |
| NCT07138456 | Not specified | NOT_YET_RECRUITING | Clinical Severity of Dental Fluorosis and Associated Risk Factors Among a Group of Children in Rural Region, Dendera Center in Egypt |
| NCT07232888 | Not specified | ACTIVE_NOT_RECRUITING | Design of a Multicomponent Intervention to Reduce the Risk of Exposure Fluorine |
| NCT07359937 | Not specified | ENROLLING_BY_INVITATION | Design of a Multicomponent Intervention to Reduce the Risk of Exposure Fluorine |
| NCT01733888 | Not specified | COMPLETED | Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains |
| NCT02925780 | Not specified | WITHDRAWN | 12 Month Follow up in Vivo Icon Study on Fluorotic Teeth |
| NCT02958891 | Not specified | UNKNOWN | Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits |
| NCT03746990 | Not specified | COMPLETED | Presence of Enamel Fluorosis in Libyan Children |
| NCT05051748 | Not specified | COMPLETED | Clinical Evaluation of Different Minimal Invasive Treatment Modalities of Mild to Moderate Dental Fluorosis Using A Visual Analog Scale |
| NCT05204277 | Not specified | COMPLETED | Clinical Evaluation of Dental Fluororsis Treatment Modalities |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| WATER | 4 | 2 |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.