Dental pulp necrosis
diseaseOn this page
Also known as necrosis of pulpnecrosis of the pulpnecrotic pulppulp necrosis
Summary
Dental pulp necrosis (MONDO:0001326) is a disease and 95 clinical trials. Top therapeutic interventions include sodium hypochlorite, chlorhexidine, and ciprofloxacin. A subtype of dental pulp disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 95
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | dental pulp necrosis |
| Mondo ID | MONDO:0001326 |
| MeSH | D003790 |
| DOID | DOID:11623 |
| ICD-10-CM | K04.1 |
| ICD-11 | 1192336635 |
| SNOMED CT | 42711005 |
| UMLS | C0011407 |
| MedGen | 8306 |
| Is cancer (heuristic) | no |
Also known as: necrosis of pulp · necrosis of the pulp · necrotic pulp · pulp necrosis
Disease family
This is a subtype of dental pulp disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › tooth disorder › dental pulp disorder › dental pulp necrosis
Related subtypes (6): pulp degeneration, pulp erosion, dental pulp calcification, pulpitis, exposure, dental pulp, secondary dentine
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 95.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 70 |
| PHASE4 | 8 |
| PHASE2/PHASE3 | 5 |
| EARLY_PHASE1 | 5 |
| PHASE2 | 3 |
| PHASE1/PHASE2 | 2 |
| PHASE3 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07388888 | PHASE4 | NOT_YET_RECRUITING | Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain |
| NCT01817413 | PHASE4 | COMPLETED | Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma |
| NCT03084601 | PHASE4 | COMPLETED | Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy |
| NCT03533231 | PHASE4 | COMPLETED | Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. |
| NCT04035070 | PHASE4 | UNKNOWN | Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria |
| NCT06116214 | PHASE4 | UNKNOWN | Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp |
| NCT06818578 | PHASE4 | COMPLETED | Success of Lesion Sterilization and Tissue Repair Therapy |
| NCT06906315 | PHASE4 | COMPLETED | Dexamethasone Treatment for Patients Undergoing Endodontics |
| NCT00472173 | PHASE3 | COMPLETED | Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth |
| NCT03376984 | PHASE2/PHASE3 | WITHDRAWN | Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy |
| NCT03849222 | PHASE2/PHASE3 | COMPLETED | Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth |
| NCT05146713 | PHASE2/PHASE3 | UNKNOWN | Effect of Propolis Nanoparticles on Postoperative Pain and Bacterial Reduction in Mandibular Premolars |
| NCT05348824 | PHASE2/PHASE3 | UNKNOWN | Effect of Moringa Oleifera Leaf Extract on Postoperative Pain and Bacterial Reduction in Mandibular Premolars |
| NCT05419752 | PHASE2/PHASE3 | UNKNOWN | Clinical Assessment of 3 Differant Obturation Sealers on Postoprative Pain and Swelling |
| NCT07475364 | PHASE1/PHASE2 | NOT_YET_RECRUITING | Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis |
| NCT00624572 | PHASE2 | UNKNOWN | Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth |
| NCT01730287 | PHASE2 | UNKNOWN | Effect Of Different Lining Materials in Stepwise Excavation |
| NCT03650036 | PHASE2 | COMPLETED | Root Canal Treatment in Primary Molars With Necrotic Pulp Using Two Different Pulp Therapies |
| NCT04587089 | PHASE1/PHASE2 | UNKNOWN | Efficacy of Guedes-Pinto Paste and CTZ Paste in the Non-instrumental Endodontic Treatment of Primary Teeth |
| NCT01976065 | PHASE1 | COMPLETED | Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots |
| NCT07542639 | EARLY_PHASE1 | NOT_YET_RECRUITING | Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial |
| NCT00881491 | EARLY_PHASE1 | COMPLETED | Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste |
| NCT00881907 | EARLY_PHASE1 | COMPLETED | Tissue Characterization in Teeth Treated With a Regeneration Protocol |
| NCT04646538 | EARLY_PHASE1 | COMPLETED | Volume Assessment of the Periapical Healing Following Regenerative Endodontic Procedures Using Cone- Bean Computed Tomography |
| NCT05582421 | EARLY_PHASE1 | UNKNOWN | Effect of Diclofenac Sodium Versus Calcium Hydroxide as Intracanal Medication on the Intensity of Postoperative Pain, Bacterial Load Reduction and MMP-9 Levels in Patients With Necrotic Pulp. |
| NCT04605445 | Not specified | RECRUITING | One Vs Two Visits Root Canal Treatments in Infected Teeth |
| NCT06631885 | Not specified | NOT_YET_RECRUITING | Efficacy of Integrated Nano-technology in Revascularization of Immature Necrotic Teeth |
| NCT06926322 | Not specified | ENROLLING_BY_INVITATION | Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair |
| NCT06934317 | Not specified | ENROLLING_BY_INVITATION | Maximum Occlusal Bite Force of Necrotic Permanent Teeth Treated by Regenerative Technique: Randomized Clinical Trial |
| NCT06959602 | Not specified | ENROLLING_BY_INVITATION | Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods |
| NCT06971055 | Not specified | NOT_YET_RECRUITING | Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars |
| NCT07048028 | Not specified | RECRUITING | Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) |
| NCT07091981 | Not specified | RECRUITING | Effect of Rotary File Number on MB2 Canal Negotiation and Postoperative Pain |
| NCT07101003 | Not specified | NOT_YET_RECRUITING | A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits |
| NCT07192289 | Not specified | NOT_YET_RECRUITING | Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth |
| NCT07230717 | Not specified | NOT_YET_RECRUITING | Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp |
| NCT07239752 | Not specified | NOT_YET_RECRUITING | Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars |
| NCT07290192 | Not specified | NOT_YET_RECRUITING | This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated Wit |
| NCT07297836 | Not specified | RECRUITING | Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France |
| NCT07310212 | Not specified | RECRUITING | Evaluation of Postoperative Pain and Success Rate Between Lateral Condensation and Warm Vertical Obturation Techniques |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| SODIUM HYPOCHLORITE | 4 | 8 |
| CHLORHEXIDINE | 4 | 1 |
| CIPROFLOXACIN | 4 | 1 |
| DICLOFENAC SODIUM | 4 | 1 |
| CALCIUM HYDROXIDE | 3 | 7 |
| PROPOLIS WAX | 3 | 2 |
| CHITOSAN LOW MOLECULAR WEIGHT (20-200 MPA.S) | 3 | 1 |
| EPIGALOCATECHIN GALLATE | 3 | 1 |
| IODOFORM | 3 | 1 |
| GUTTA PERCHA | -1 | 2 |