Dentin caries
diseaseOn this page
Also known as dental caries extending into dentinedental caries of dentinedentine dental caries
Summary
Dentin caries (MONDO:0001041) is a disease and 11 clinical trials. Top therapeutic interventions include fluoride ion, hesperidin, and propolis wax. A subtype of dental caries — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 11
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | dentin caries |
| Mondo ID | MONDO:0001041 |
| DOID | DOID:10461 |
| ICD-11 | 1620059450 |
| SNOMED CT | 442551007 |
| UMLS | C0266846 |
| MedGen | 540210 |
| Anatomy (UBERON) | UBERON:0001751 |
| Is cancer (heuristic) | no |
Also known as: dental caries extending into dentine · dental caries of dentine · dentine dental caries
Disease family
This is a subtype of dental caries. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › tooth disorder › tooth hard tissue disease › dental caries › dentin caries
Related subtypes (4): odontoclasia, enamel caries, pit and fissure surface dental caries, smooth surface dental caries
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 11.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 9 |
| PHASE2 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06580678 | PHASE2 | COMPLETED | A Study to Evaluate Physiologic Dentin Regeneration and Safety of KH001 in the Administration of Erupted Wisdom Tooth With Dentin Caries |
| NCT07065305 | EARLY_PHASE1 | NOT_YET_RECRUITING | Clinical Performance and Remineralization Potential of Self- Assembling Peptide P11-4 Containing Fluoride Versus Er, Cr: YSGG Laser Treatment and Micro Tensile Bond Strength of Giomer Restoration in Carious Lesions |
| NCT07343050 | Not specified | RECRUITING | Evaluation of the Effect of Flowable Composites on Postoperative Sensitivity in Class I Restorations. |
| NCT07343063 | Not specified | RECRUITING | Evaluation of the Clinical Performance of Different Composite Materials in Class III and IV Restorations. |
| NCT01749267 | Not specified | COMPLETED | Digital Subtraction Radiography Evaluation of SMART Restoration With Partial Caries Removal in Primary Teeth |
| NCT02217098 | Not specified | COMPLETED | The Survival Rate of Glass Ionomer Cement, Glass Carbomer Cement and Compomer in Occlusal and Proximal ART Restorations |
| NCT04145102 | Not specified | COMPLETED | Evaluation of the Remineralizing and Antibacterial Effect of Natural Versus Synthetic Materials on Deep Carious Dentin |
| NCT04813744 | Not specified | COMPLETED | Microbiological and Microscopic Evaluation of Atraumatic Restorative Treatment in Adult Dentition |
| NCT06256601 | Not specified | UNKNOWN | Clinical Investigation of Effectiveness of a Calcium Silicate Cement |
| NCT06771362 | Not specified | COMPLETED | Evaluation of ART Restorations Using Two Different Bulk-Fill Restorative Materials in Primary Molars |
| NCT07260357 | Not specified | COMPLETED | Comparison Of Clinical And Radiological Success Of Pulpotomy Treatments Performed With Proroot MTA, NeoPUTTY MTA, TheraCal PT In Primary Teeth |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| FLUORIDE ION | 3 | 1 |
| HESPERIDIN | 3 | 1 |
| PROPOLIS WAX | 3 | 1 |
| SILVER DIAMMINE FLUORIDE | 3 | 1 |
| CARBOMER 910 | 2 | 1 |
| FLUORIDE | 0 | 1 |