Dentin sensitivity
diseaseOn this page
Summary
Dentin sensitivity (MONDO:0004059) is a disease and 97 clinical trials. Top therapeutic interventions include potassium nitrate, sodium fluoride, and sodium monofluorophosphate. A subtype of tooth hard tissue disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 97
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | dentin sensitivity |
| Mondo ID | MONDO:0004059 |
| MeSH | D003807 |
| DOID | DOID:698 |
| SNOMED CT | 13468005 |
| UMLS | C0011432 |
| MedGen | 41477 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of tooth hard tissue disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › tooth disorder › tooth hard tissue disease › dentin sensitivity
Related subtypes (6): tooth resorption, dental enamel hypoplasia, dental caries, hypercementosis, tooth ankylosis, dentin dysplasia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 97.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 73 |
| PHASE4 | 7 |
| PHASE2 | 7 |
| PHASE3 | 3 |
| PHASE1 | 3 |
| PHASE2/PHASE3 | 2 |
| PHASE1/PHASE2 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02017873 | PHASE4 | COMPLETED | Longevity and Effectiveness of Bleaching in Healthy and Smokers Patients |
| NCT02461030 | PHASE4 | COMPLETED | Efficacy of Two Oral Hygiene Regimens in the Reduction of Dentin Hypersensitivity After Periodontal Treatment |
| NCT02731833 | PHASE4 | COMPLETED | Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity |
| NCT02773758 | PHASE4 | COMPLETED | Study to Investigate the Efficacy of an Occluding Dentifrice in Providing Relief From Dentine Hypersensitivity |
| NCT02895321 | PHASE4 | COMPLETED | Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity |
| NCT02923895 | PHASE4 | COMPLETED | To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH) |
| NCT06608368 | PHASE4 | COMPLETED | A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching |
| NCT02128633 | PHASE2/PHASE3 | COMPLETED | Effectiveness of a Homecare Dentin Hypersensitivity Gel |
| NCT02829879 | PHASE3 | UNKNOWN | Effectiveness of Arginin and Potassium Nitrate Dentifrices in Dentin Hypersensitivity Therapy |
| NCT02832375 | PHASE3 | COMPLETED | Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity |
| NCT04485299 | PHASE2/PHASE3 | UNKNOWN | Clinical Assessment of Bifluorid 10 vs Varnish Fluoride on The Exposed Hypersensitive Cervical Dentin in Adult Patient |
| NCT04591444 | PHASE3 | COMPLETED | Fluoride Varnish X Glass Ionomer Sealant on Cervical Dentin Hypersensitivity |
| NCT06417580 | PHASE2 | NOT_YET_RECRUITING | Effect of Pregabalin Gel in Controlling Cervical Dentin Hypersensitivity |
| NCT02226562 | PHASE2 | COMPLETED | Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity |
| NCT02918617 | PHASE2 | COMPLETED | Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream |
| NCT03238352 | PHASE2 | COMPLETED | A Study to Assess Efficacy of an Experimental Oral Rinse in Providing Long Term Relief From Dentinal Hypersensitivity |
| NCT03361774 | PHASE2 | WITHDRAWN | A Clinical Method Development Study to Characterise The Efficacy of a Dentifrice For The Relief Of Dentin Hypersensitivity |
| NCT03943095 | PHASE2 | COMPLETED | Study to Characterize the Efficacy of a Dual Active Dentifrice for the Relief of Dentin Hypersensitivity |
| NCT04407702 | PHASE1/PHASE2 | UNKNOWN | Control of Pain Due to Dentin Hypersensitivity in Individuals With Molar-incisor Hypomineralization |
| NCT04804514 | PHASE1/PHASE2 | COMPLETED | Evaluation of the Safety and Tolerability of KH001 in Dentin Hypersensitivity Patients |
| NCT05853523 | PHASE2 | COMPLETED | The Desensitizing Treatment Effects of the Laser and Ozone on Dentin Hypersensitivity: In-vivo Comparison |
| NCT07027566 | PHASE1 | NOT_YET_RECRUITING | Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity |
| NCT03044171 | PHASE1 | COMPLETED | Evaluation of the Effect of Fluoride and Laser Application on the Prevention of Sensitivity in Bleached Teeth |
| NCT03434782 | PHASE1 | COMPLETED | Effect of Laser and Potassium Nitrate Application on the Sensitivity Control in Bleached Teeth |
| NCT06463938 | Not specified | RECRUITING | A Clinical Trial to Compare Lasotronix Alone or in Combination With CPP-ACP to Treat DH |
| NCT06582238 | Not specified | ENROLLING_BY_INVITATION | Dentine Hypersensitivity Management KAP Study |
| NCT06802614 | Not specified | NOT_YET_RECRUITING | Efficacy and Safety Assessment of Experimental Bleaching Agents |
| NCT07300540 | Not specified | RECRUITING | Real-World Study of a Calcium Sodium Phosphosilicate Anti-Sensitivity Toothpaste for Dentin Hypersensitivity Relief |
| NCT01111474 | Not specified | COMPLETED | Cyanoacrylate and Laser and Dentin Sensitivity |
| NCT01133379 | Not specified | COMPLETED | Tooth Sensitivity Relief by Two Mouthrinses |
| NCT01345292 | Not specified | COMPLETED | A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device |
| NCT01427764 | Not specified | COMPLETED | Dentin Hypersensitivity Following Non-surgical Periodontal Therapy With Hand or Ultrasonic Instruments |
| NCT01727258 | Not specified | COMPLETED | A Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity |
| NCT01959789 | Not specified | COMPLETED | In-office Bleaching With a 2-day Interval Between Sessions: Tooth Sensitivity |
| NCT02113579 | Not specified | COMPLETED | Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity |
| NCT02152826 | Not specified | COMPLETED | Effectiveness of Two Water-Based Potassium Oxalate Desensitizers on Dental Hypersensitivity |
| NCT02189382 | Not specified | COMPLETED | Evaluation of the Safety and Efficacy of an Oxalate Gel or Negative Control on Dentinal Hypersensitivity |
| NCT02192307 | Not specified | COMPLETED | Effectiveness of Two Water-Based Potassium Oxalate Desensitizers |
| NCT02221349 | Not specified | COMPLETED | A Clinical Study of Two Dentinal Hypersensitivity Treatments Used With Normal Oral Hygiene |
| NCT02293044 | Not specified | COMPLETED | A Study to Evaluate the Safety and Efficacy of an Oxalate Strip on Adjacent Teeth With Dentinal Hypersensitivity |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| POTASSIUM NITRATE | 4 | 6 |
| SODIUM FLUORIDE | 4 | 5 |
| SODIUM MONOFLUOROPHOSPHATE | 4 | 5 |
| PHOSPHORIC ACID | 4 | 1 |
| STANNOUS FLUORIDE | 3 | 9 |
| POTASSIUM | 3 | 6 |
| FLUORIDE ION | 3 | 4 |
| PROPOLIS WAX | 3 | 2 |
| CALCIUM SODIUM PHOSPHOSILICATE | 3 | 1 |
| MECRYLATE | 3 | 1 |
| NITRIC ACID | 3 | 1 |
| STRONTIUM | 3 | 1 |
| THEOBROMINE | 3 | 1 |
| FLUORIDE | 0 | 6 |
| SODIUM OXALATE | 0 | 6 |
| CHEMBL1208639 | 0 | 5 |
| CHEMBL186200 | 0 | 1 |
| OXALIC ACID | -1 | 6 |