Denture stomatitis

disease

On this page

Summary

Denture stomatitis (MONDO:0006723) is a disease and 17 clinical trials. Top therapeutic interventions include nystatin, clotrimazole, and garlic. A subtype of stomatitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

Clinical trials: 17

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	denture stomatitis
Mondo ID	MONDO:0006723
EFO	EFO:1000893
MeSH	D013282
DOID	DOID:11875
SNOMED CT	69254008
UMLS	C0038364
MedGen	21333
Is cancer (heuristic)	no

Disease family

This is a subtype of stomatitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › inflammatory disease › mucositis › stomatitis › denture stomatitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Garlic, Nystatin.

Clinical trials & evidence

Clinical trials

Clinical trials: 17.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	13
PHASE2	2
PHASE1	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00835029	PHASE2	COMPLETED	Efficacy of Slow Release Clotrimazole Varnish Treating Denture Stomatitis Comparing to Traditional Treatment of Troches
NCT01198223	PHASE2	COMPLETED	Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis
NCT01643876	PHASE1	COMPLETED	The Effect of Palatal Brushing on Denture Stomatitis
NCT02950584	PHASE1	UNKNOWN	Surface Roughness of Heat Cured Acrylic Resin Versus Acrylic Resin With Titanium Dioxide
NCT07608211	Not specified	NOT_YET_RECRUITING	Development of a Sanitizing Tablet for Removable Partial Dentures
NCT01237782	Not specified	COMPLETED	Efficacy of a Propolis-based Denture Cleanser
NCT01237795	Not specified	COMPLETED	Experimental Denture Pastes
NCT02166450	Not specified	UNKNOWN	Effects of Denture-Related Stomatitis on Blood Pressure in Denture Wearers
NCT02686632	Not specified	COMPLETED	The Effectiveness of Palatal Brushing on Denture Stomatitis
NCT02834832	Not specified	COMPLETED	Novel Coating to Minimize Bacterial Adhesions and Tooth Wear in Denture Acrylic
NCT02950623	Not specified	UNKNOWN	Microbiological Study on Maxillary Complete Dentures of Two Different Materials
NCT03666195	Not specified	UNKNOWN	The Anti-microbial Effect of Titanium Dioxide Nano Particles in Complete Dentures Made for Edentulous Patients
NCT05466305	Not specified	UNKNOWN	Assessment of Maxillary Acrylic Resin Complete Dentures Reinforced by Gold Plated Cr-Co Palatal Plate
NCT06021847	Not specified	COMPLETED	Ozonated Water in Treatment of Denture Stomatitis
NCT06395116	Not specified	UNKNOWN	Microbial Adhesion and Biofilm Formation on Denture Base Materials
NCT06921577	Not specified	COMPLETED	Clinical and Microbial Study of Reinforced 3D Printed Maxillary Denture Base Resin
NCT07475195	Not specified	COMPLETED	Oral Probiotics and Denture Care in Saudi Arabia: Evaluating Knowledge, Practices, and the Future of Innovative Hygiene Solutions

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
NYSTATIN	4	2
CLOTRIMAZOLE	4	1
GARLIC	3	1
CHEMBL450895	0	2

Drugs: Nystatin, Clotrimazole, Garlic