Diarrheal disease

Summary

Diarrheal disease (MONDO:0001673) is a disease (an umbrella term covering 7 Mondo subtypes) and 436 clinical trials. Top therapeutic interventions include loperamide, octreotide, and ondansetron. A subtype of digestive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 7 Mondo subtypes
• Clinical trials: 436

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	diarrheal disease
Mondo ID	MONDO:0001673
MeSH	D003967
DOID	DOID:13250
ICD-11	116759077
NCIT	C2987
SNOMED CT	128333008
UMLS	C1290807
MedGen	713159
Is cancer (heuristic)	no

Also known as: diarrhea · diarrheal disease · diarrheal disorder · diarrhoea · diarrhoea of presumed infectious origin · frequent stools · loose stools

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of digestive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › diarrheal disease

Related subtypes (30): benign digestive system neoplasm, autoimmune disorder of gastrointestinal tract, gastrointestinal mucositis, pancreas disorder, hepatobiliary disorder, digestive system cancer, peptic ulcer disease, stomach disorder, intestinal disorder, Meckel diverticulum, Cronkhite-Canada syndrome, diverticulosis, small-intestinal, diverticulosis of bowel, hernia, and retinal detachment, congenital enteropathy due to enteropeptidase deficiency, hereditary mixed polyposis syndrome, caudal duplication, Moyamoya disease with early-onset achalasia, hyperplastic polyposis syndrome, thoraco-abdominal enteric duplication, digestive duplication, juvenile polyposis syndrome, umbilical cord ulceration-intestinal atresia syndrome, growth retardation-mild developmental delay-chronic hepatitis syndrome, common mesentery, neoplasm of oropharynx, gastrointestinal polyp, digestive system neuroendocrine neoplasm, digestive system infectious disorder, upper digestive tract disorder, congenital peritoneal encapsulation

Subtypes (7): secretory diarrhea, diarrheal disease secondary to altered bowel motility, inflammatory diarrhea, acute diarrhea, congenital diarrhea, chronic diarrheal disease, non-infectious diarrheal disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

7 approved, 22 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Bismuth Subsalicylate	Approved (phase 4)
Crofelemer	Approved (phase 4)
Eluxadoline	Approved (phase 4)
Fidaxomicin	Approved (phase 4)
Nitazoxanide	Approved (phase 4)
Rifaximin	Approved (phase 4)
Vancomycin	Approved (phase 4)
Amylase (Pancrelipase)	Phase 3 (in late-stage trials)
Azithromycin	Phase 3 (in late-stage trials)
Calcium Carbonate	Phase 3 (in late-stage trials)
Ciprofloxacin	Phase 3 (in late-stage trials)
Glutamine	Phase 3 (in late-stage trials)
Glycine	Phase 3 (in late-stage trials)
Lactose, Anhydrous	Phase 3 (in late-stage trials)
Lamivudine	Phase 3 (in late-stage trials)
Loperamide	Phase 3 (in late-stage trials)
Metronidazole	Phase 3 (in late-stage trials)
Montmorillonite	Phase 3 (in late-stage trials)
Nelfinavir	Phase 3 (in late-stage trials)
Octreotide	Phase 3 (in late-stage trials)
Pentosan Polysulfate Sodium	Phase 3 (in late-stage trials)
Racecadotril	Phase 3 (in late-stage trials)
Retinol	Phase 3 (in late-stage trials)
Rifampin	Phase 3 (in late-stage trials)
Rifamycin	Phase 3 (in late-stage trials)
Simethicone	Phase 3 (in late-stage trials)
Starch	Phase 3 (in late-stage trials)
Zidovudine	Phase 3 (in late-stage trials)
Zinc Ion	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Bifidobacterium Spp., Budesonide, Lactobacillus Acidophilus, Lactoferrin, Bovine, Lanreotide, Maltodextrin, Zinc Sulfate.

Clinical trials & evidence

Clinical trials

Clinical trials: 436.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	221
PHASE3	64
PHASE2	50
PHASE4	43
PHASE1	25
PHASE2/PHASE3	16
PHASE1/PHASE2	13
EARLY_PHASE1	4

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06990568	PHASE4	NOT_YET_RECRUITING	Impact of Probiotics on Antibiotic-associated Diarrhea in Community-acquired Pneumonia
NCT07285785	PHASE4	RECRUITING	Rifaximin 200 mg Plus Oral Rehydration vs Oral Rehydration Alone in Children With Acute Diarrhea
NCT07300462	PHASE4	NOT_YET_RECRUITING	A Post-marketing Observational Study of Oral Cholera Vaccine
NCT00050635	PHASE4	COMPLETED	STOP Trial - Sandostatin LAR Depot Trial for the Optimum Prevention of Chemotherapy Induced Diarrhea
NCT00137657	PHASE4	COMPLETED	Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on Antifolate Resistance
NCT00228254	PHASE4	COMPLETED	Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study
NCT00244777	PHASE4	COMPLETED	Introduction of Hypo-osmolar ORS for Routine Use
NCT00276328	PHASE4	COMPLETED	Study to Evaluate Smecta® vs Placebo on the Time to Recovery Following an Acute Diarrhoea Episode in Adults
NCT00359970	PHASE4	COMPLETED	Azithromycin, With or Without Loperamide, to Treat Travelers’ Diarrhea
NCT00463190	PHASE4	COMPLETED	Effect of Probiotics (Bio-Three) in Children’s Enterocolitis
NCT00470158	PHASE4	COMPLETED	Delivery of Iron and Zinc Supplements: Evaluation of Interaction Effect on Biochemical and Clinical Outcomes
NCT00490932	PHASE4	COMPLETED	New Hypo-Osmolar ORS (Recommended by WHO) for Routine Use in the Diarrhea Management- Surveillance Study for Adverse Effects
NCT00685607	PHASE4	COMPLETED	Study to Determine the Best Way to Measure How Quickly the Drug Can Give Relief From Sudden Diarrhea
NCT00763399	PHASE4	COMPLETED	Effect of Probiotics on Intestinal Bacterial Population and Immune Modulation
NCT00807326	PHASE4	COMPLETED	A Comparison of Three Medications to Treat Diarrhea in Adults.
NCT00942812	PHASE4	COMPLETED	Community Based Intervention and Evaluation of the Impact of Social Marketing of a Diarrhea Management Pack
NCT01278017	PHASE4	UNKNOWN	The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis
NCT01467570	PHASE4	COMPLETED	Efficacy and Safety of a New Oral Rehydration Solution (Hipp ORS 200 Apple) in Children With Acute Gastroenteritis
NCT01480947	PHASE4	COMPLETED	The Treatment Effect of Bio-Three on Children With Enteritis
NCT01491659	PHASE4	WITHDRAWN	A Study to Evaluate the Effect and Safety of Idoform Plus on Bowel Side Effects in Healthy Subjects Treated With Amoxicillin/ Clavulanate
NCT01657032	PHASE4	COMPLETED	Efficacy of Lactobacillus GG With Diosmectite in Treatment Children With Acute Gastroenteritis
NCT01791608	PHASE4	COMPLETED	Zinc Sulphate vs. Zinc Amino Acid Chelate
NCT01792739	PHASE4	UNKNOWN	Lactobacillus Preparation on the Incidence of Diarrhea
NCT01870635	PHASE4	COMPLETED	Ondansetron Administration to WELL Children With Gastroenteritis Associated Vomiting in EDs in Pakistan
NCT01870648	PHASE4	COMPLETED	Ondansetron Administration to Children With Gastroenteritis, Vomiting and SOME Dehydration in EDs in Pakistan
NCT01960725	PHASE4	COMPLETED	An Alternate Dosing Schedule for Pentavalent Rotavirus Vaccine (RotaTeq)
NCT02057198	PHASE4	COMPLETED	Impact of Oral Antibiotic Treatment on C. Difficile
NCT02414399	PHASE4	UNKNOWN	Azithromycin to Prevent Post-discharge Morbidity and Mortality in Kenyan Children
NCT02462590	PHASE4	COMPLETED	Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial
NCT02597556	PHASE4	WITHDRAWN	The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children
NCT02607176	PHASE4	COMPLETED	Heweizhixie capsuleTherapy on Patients With Diarrhea
NCT02748616	PHASE4	COMPLETED	C. Difficile and Ursodiol
NCT02871908	PHASE4	COMPLETED	Lactobacillus Reuteri DSM 17938 in the Prevention of Antibiotic-associated Diarrhea in Children: Protocol of a Randomized Controlled Trial
NCT02949882	PHASE4	UNKNOWN	Improving Bowel Habits of Elderly With Probiotics and Non-probiotics
NCT03388268	PHASE4	COMPLETED	TOX NEG Trial: Clostridium Difficile Diagnosis and Treatment
NCT03587389	PHASE4	COMPLETED	Response to Rotavirus Vaccine in Infants in Ho Chi Minh City in Vietnam
NCT03656198	PHASE4	COMPLETED	Non-specific Effects of Rabies Vaccine
NCT03854929	PHASE4	COMPLETED	Ciprofloxacin Versus Azithromycin for Children Hospitalised With Dysentery
NCT04486326	PHASE4	TERMINATED	Crofelemer for Functional Diarrhea
NCT04811339	PHASE4	COMPLETED	Studies of COVID-19 Patients Treated With Oral Bismuth Subsalicylate (Pepto-Bismol)

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
LOPERAMIDE	4	15
OCTREOTIDE	4	10
ONDANSETRON	4	9
RIFAXIMIN	4	7
VANCOMYCIN	4	5
FIDAXOMICIN	4	4
RACECADOTRIL	4	4
AZITHROMYCIN	4	3
CROFELEMER	4	3
RETINOL	4	3
ROTAVIRUS, LIVE ATTENUATED	4	3
ZINC SULFATE	4	3
BISMUTH SUBSALICYLATE	4	2
COLESEVELAM	4	2
ELUXADOLINE	4	2
LEUCOVORIN	4	2
MESALAMINE	4	2
NITAZOXANIDE	4	2
POLYETHYLENE GLYCOL 3350	4	2
ALBENDAZOLE	4	1
BUDESONIDE	4	1
CABAZITAXEL	4	1
CALCIUM CARBONATE	4	1
CEFIXIME	4	1
CEFPODOXIME	4	1
CEFPODOXIME PROXETIL	4	1
CEFTRIAXONE	4	1
CIPROFLOXACIN	4	1
CYANOCOBALAMIN	4	1
FERROUS SULFATE	4	1