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Digestive system infectious disorder

disease
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Also known as digestive system infectiongastrointestinal infectiongastrointestinal system infection

Summary

Digestive system infectious disorder (MONDO:0043424) is a disease (an umbrella term covering 22 Mondo subtypes) with 20 GWAS associations across 1 studies and 22 clinical trials. Top therapeutic interventions include cephalexin anhydrous, doxycycline anhydrous, and levofloxacin anhydrous. A subtype of digestive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Umbrella term: 22 Mondo subtypes
  • GWAS associations: 20
  • Clinical trials: 22

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namedigestive system infectious disorder
Mondo IDMONDO:0043424
NCITC35503
SNOMED CT715852004
Anatomy (UBERON)UBERON:0005409
Is cancer (heuristic)no

Also known as: digestive system infection · gastrointestinal infection · gastrointestinal system infection

Data availability: 20 GWAS associations (1 study).

Disease family

This is a subtype of digestive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › digestive system infectious disorder

Related subtypes (30): benign digestive system neoplasm, autoimmune disorder of gastrointestinal tract, gastrointestinal mucositis, diarrheal disease, pancreas disorder, hepatobiliary disorder, digestive system cancer, peptic ulcer disease, stomach disorder, intestinal disorder, Meckel diverticulum, Cronkhite-Canada syndrome, diverticulosis, small-intestinal, diverticulosis of bowel, hernia, and retinal detachment, congenital enteropathy due to enteropeptidase deficiency, hereditary mixed polyposis syndrome, caudal duplication, Moyamoya disease with early-onset achalasia, hyperplastic polyposis syndrome, thoraco-abdominal enteric duplication, digestive duplication, juvenile polyposis syndrome, umbilical cord ulceration-intestinal atresia syndrome, growth retardation-mild developmental delay-chronic hepatitis syndrome, common mesentery, neoplasm of oropharynx, gastrointestinal polyp, digestive system neuroendocrine neoplasm, upper digestive tract disorder, congenital peritoneal encapsulation

Subtypes (22): oropharyngeal anthrax, polycystic echinococcosis, intestinal infectious disease, fungal esophagitis, bacterial esophagitis, viral gastritis, bacterial gastritis, fungal gastritis, viral esophagitis, anal verrucous carcinoma, Whipple disease, campylobacteriosis, gastrointestinal tuberculosis, Salmonella gastroenteritis, viral hepatitis, infectious colitis, parasitic intestinal disorder, internal hirudiniasis, Aeromonas hydrophila intestinal disease, colorectal Kaposi sarcoma, small intestinal bacterial overgrowth, liver abscess (disease)

Genetics & variants

GWAS landscape

20 GWAS associations across 1 studies. Top hits map to 13 distinct genes (as reported by GWAS).

Top associations by p-value

rsIDp-valueGeneRisk alleleOdds ratio
rs6356343e-08ABO - Y_RNAT1.13
rs413026735e-07STKLD1G1.17
rs1152497661e-06RBMS3C1.49
rs3696142512e-06CD96C1.15
rs30102562e-06TNPO1-DTT1.34
rs1173474732e-06LINC02402A1.26
rs18661642e-06PPIAP16 - FLNBT1.35
rs1435383604e-06LINC01911 - RNU6-692PC1.55
rs71122534e-06CNTN5A1.12
rs125177274e-06LINC02997A1.16
rs758873875e-06BUD13P1 - LNCRNA-IURG1.12
rs354397595e-06LUC7L3CTT1.09
rs37931026e-06ATXN1A1.09
rs71832317e-06TYRO3C1.09
rs3764799267e-06LINC02748 - LINC02756C1.49
rs119952447e-06MFHAS1T1.37
chr3:1882408578e-06G1.44
rs38251658e-06ITPR2-AS2, ITPR2T1.16
rs16523629e-06NPC1 - ANKRD29T1.19
chr2:2078837279e-06G1.32

Top studies (by case count)

StudyLead authorYearCasesControlsTitle
GCST010008Nudel R20207,19737,062A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

TierVariants
Tier 1: coding1
Tier 2: splice/UTR1
Tier 3: regulatory0
Tier 4: intronic/intergenic18

MAF distribution

BucketVariants
common (>=0.05)14
low_freq (0.01-0.05)0
rare (<0.01)0
unknown6

Functional consequences

ConsequenceCount
intron_variant10
intergenic_variant6
unknown2
missense_variant1
3_prime_UTR_variant1

Top variants

rsIDChrPosAllelesMAFConsequenceGenep-valueTier
rs6356349133279427T>A,C0.05intergenic_variantABO - Y_RNA3e-08Tier 4: intronic/intergenic
rs413026739133405414T>G0.05missense_variantSTKLD15e-07Tier 1: coding
rs115249766328650645T>Cintron_variantRBMS31e-06Tier 4: intronic/intergenic
rs3696142513111561865intron_variantCD962e-06Tier 4: intronic/intergenic
rs3010256572682599T>C0.05intron_variantTNPO1-DT2e-06Tier 4: intronic/intergenic
rs1173474731242624720C>A,T0.05intron_variantLINC024022e-06Tier 4: intronic/intergenic
rs1866164357985796C>T0.05intergenic_variantPPIAP16 - FLNB2e-06Tier 4: intronic/intergenic
rs1435383602147162376T>Cintergenic_variantLINC01911 - RNU6-692P4e-06Tier 4: intronic/intergenic
rs711225311100065492A>G0.05intron_variantCNTN54e-06Tier 4: intronic/intergenic
rs12517727567720940G>A0.05intron_variantLINC029974e-06Tier 4: intronic/intergenic
rs758873871195146961G>T0.05intergenic_variantBUD13P1 - LNCRNA-IUR5e-06Tier 4: intronic/intergenic
rs354397591750726160C>CTT0.05intron_variantLUC7L35e-06Tier 4: intronic/intergenic
rs3793102616680847A>C,G,T0.05intron_variantATXN16e-06Tier 4: intronic/intergenic
rs71832311541583162A>C,G,T0.053_prime_UTR_variantTYRO37e-06Tier 2: splice/UTR
rs3764799261191380674A>C,Gintergenic_variantLINC02748 - LINC027567e-06Tier 4: intronic/intergenic
rs1199524488832883G>A,C,T0.05intron_variantMFHAS17e-06Tier 4: intronic/intergenic
chr3:1882408578e-06Tier 4: intronic/intergenic
rs38251651226402797T>A,C0.05intron_variantITPR2-AS2, ITPR28e-06Tier 4: intronic/intergenic
rs16523621823596806T>C0.05intergenic_variantNPC1 - ANKRD299e-06Tier 4: intronic/intergenic
chr2:2078837279e-06Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 22.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified16
PHASE33
PHASE42
PHASE21

Top trials by phase / activity

NCTPhaseStatusTitle
NCT01782118PHASE4UNKNOWNLGG for Prevention of Infectious Complications During PPI Treatment in Children
NCT05977868PHASE4TERMINATEDComparing Oral Versus Parenteral Antimicrobial Therapy
NCT06560255PHASE3RECRUITINGFish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma
NCT06570889PHASE3RECRUITINGVItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma
NCT01909128PHASE3COMPLETEDFermented Milk and Fermented Rice on the Appearance of Respiratory and Gastrointestinal Symptoms
NCT04501380PHASE2UNKNOWNEfficacy of AEMCOLO (Rifamycin SV MMX) in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO)
NCT04826991Not specifiedACTIVE_NOT_RECRUITINGWells and Enteric Disease Transmission
NCT01304914Not specifiedCOMPLETEDObservational Research in Childhood Infectious Diseases Study
NCT02032056Not specifiedTERMINATEDEffect of Probiotics in Reducing Infections and Allergies in Young Children During the Complementary Feeding Period
NCT02131727Not specifiedCOMPLETEDHand Hygiene Randomized Cluster Intervention to Reduce Infections
NCT02180581Not specifiedCOMPLETEDEffect of Probiotics in Reducing Infections and Allergies in Young Children Starting Daycare
NCT02729870Not specifiedWITHDRAWNOral Glucose Intervention for Children With Gastroenteritis and Ketosis
NCT03299283Not specifiedUNKNOWNSpecimen Collection and Transport Workflow Evaluations for CLIA-waived Molecular Testing
NCT03342547Not specifiedUNKNOWNIdentification of Host Factors of Norovirus Infections in Mini-Gut Model
NCT03454009Not specifiedCOMPLETEDKent State University / Price Chopper Employee Wellness Study
NCT04239521Not specifiedCOMPLETEDThe Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
NCT04258059Not specifiedCOMPLETEDWells and Enteric Disease Transmission Trial (WET - Trial)
NCT04803435Not specifiedUNKNOWNTelemedicine and Face-to-face Consultations Diagnostic Accuracy Comparison in Gastrointestinal Infection Patients
NCT05051358Not specifiedUNKNOWNTherapeutic Endoscopic Ultrasound for Gastrointestinal Disorders: A Multicenter Registry Study
NCT05322655Not specifiedCOMPLETEDPAthogen Transmission and Health Outcome Models of Enteric Disease
NCT05484102Not specifiedCOMPLETEDPreventive Effect of Cow’s Milk Fermented With Lactobacillus Paracasei CBA L74 on Common Infectious Diseases in Children
NCT06745414Not specifiedCOMPLETEDClinical Performance of QIAstat-Dx® Gastrointestinal Panel 2

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
CEPHALEXIN ANHYDROUS43
DOXYCYCLINE ANHYDROUS43
LEVOFLOXACIN ANHYDROUS42
AMOXICILLIN41
AMPICILLIN41
CEFADROXIL41
CEFAZOLIN41
CEFEPIME41
CEFPODOXIME41
CEFPODOXIME PROXETIL41
CEFTAROLINE FOSAMIL41
CEFTAZIDIME41
CIPROFLOXACIN41
DALBAVANCIN41
DAPTOMYCIN41
DELAFLOXACIN41
ERTAPENEM41
LINEZOLID41
OFLOXACIN41
OLIVE OIL41
CEFTAROLINE31
CHEMBL155581301
CHEMBL164972201
CHEMBL38826601
CHEMBL428678401
CHEMBL474020001
CHEMBL474444401
CHEMBL477823901
CHEMBL478539201
CHEMBL617470501

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 19

This page pulls from 19 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardbsnpefogenccgwasgwas_studyhgncmeshmimmondomondochildmondoparentncitorphanetsctiduberon