dilated cardiomyopathy 1G

Summary

dilated cardiomyopathy 1G (MONDO:0011400) is a disease caused by TTN (GenCC Definitive), with 11 cohort genes.

At a glance

• Causal gene: TTN (GenCC Definitive)
• Cohort genes: 11
• ClinVar variants: 26,884

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	dilated cardiomyopathy 1G
Mondo ID	MONDO:0011400
MeSH	C565824
OMIM	604145
DOID	DOID:0110430
UMLS	C1858763
MedGen	347714
GARD	0015363
Is cancer (heuristic)	no

Also known as: cardiomyopathy, dilated, 1G · cardiomyopathy, dilated, type 1G · CMD1G · dilated cardiomyopathy type 1G · familial isolated dilated cardiomyopathy caused by mutation in TTN · TTN familial isolated dilated cardiomyopathy

Data availability: 26,884 ClinVar variants · 3 GenCC gene-disease records · 12 cell lines.

Disease family

Classification path: disease › human disease › disease by etiologic mechanism › disease of genetic or genomic mechanism › hereditary disease › autosomal genetic disease › autosomal dominant disease › autosomal dominant titinopathy › dilated cardiomyopathy 1G

Related subtypes (4): tibial muscular dystrophy, myopathy, myofibrillar, 9, with early respiratory failure, hypertrophic cardiomyopathy 9, TTN-related myopathy, dominant-negative TTNsv

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

ClinVar germline variants

600 retrieved; paginated sample, class counts are floors:

238 likely pathogenic, 172 uncertain significance, 140 likely benign, 18 pathogenic, 18 conflicting classifications of pathogenicity, 13 pathogenic/likely pathogenic, 1 benign

ClinVar	Variant (HGVS)	Gene	Classification	Review
1012352	NM_001267550.2(TTN):c.68302A>T (p.Lys22768Ter)	LOC126806423	Pathogenic	no assertion criteria provided
1011266	NM_001267550.2(TTN):c.6825del (p.Asp2275fs)	TTN	Pathogenic	criteria provided, single submitter
1012335	NM_001267550.2(TTN):c.81274C>T (p.Gln27092Ter)	TTN	Pathogenic	no assertion criteria provided
1012351	NM_001267550.2(TTN):c.49669A>T (p.Lys16557Ter)	TTN	Pathogenic	no assertion criteria provided
1012357	NM_001267550.2(TTN):c.3073dup (p.Ser1025fs)	TTN	Pathogenic	no assertion criteria provided
1012358	NM_001267550.2(TTN):c.58240_58244del (p.Pro19414fs)	TTN	Pathogenic	no assertion criteria provided
1015906	NM_001267550.2(TTN):c.26287G>T (p.Glu8763Ter)	TTN	Pathogenic	criteria provided, single submitter
1016464	NM_001267550.2(TTN):c.32312-1G>C	TTN	Pathogenic	criteria provided, single submitter
1030169	NM_001267550.2(TTN):c.107224-1G>C	TTN	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1035316	NM_001267550.2(TTN):c.6570dup (p.Met2191fs)	TTN	Pathogenic	criteria provided, single submitter
1057336	NM_001267550.2(TTN):c.3344G>A (p.Trp1115Ter)	TTN	Pathogenic	criteria provided, single submitter
1065903	NM_001267550.2(TTN):c.47314C>T (p.Arg15772Ter)	TTN	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1066283	NM_001267550.2(TTN):c.93088del (p.Arg31030fs)	TTN	Pathogenic	criteria provided, single submitter
1066477	NM_001267550.2(TTN):c.101687C>A (p.Ser33896Ter)	TTN	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1066644	NM_001267550.2(TTN):c.96849del (p.Gly32284fs)	TTN	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1066907	NM_001267550.2(TTN):c.51667C>T (p.Arg17223Ter)	TTN	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1067013	NM_001267550.2(TTN):c.69421_69422insAAAAG (p.Gly23141fs)	TTN	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1067751	NM_001267550.2(TTN):c.66968del (p.Asn22323fs)	TTN	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1069899	NM_001267550.2(TTN):c.77646del (p.Ile25883fs)	TTN	Pathogenic	criteria provided, single submitter
1071779	NM_001267550.2(TTN):c.88462dup (p.Cys29488fs)	TTN	Pathogenic	criteria provided, single submitter
1074124	NM_001267550.2(TTN):c.67348C>T (p.Gln22450Ter)	TTN	Pathogenic	criteria provided, multiple submitters, no conflicts
1076903	NM_001267550.2(TTN):c.85011_85014del (p.Glu28338fs)	TTN	Pathogenic	criteria provided, single submitter
1012354	NM_001267550.2(TTN):c.94754T>G (p.Leu31585Ter)	TTN-AS1	Pathogenic	no assertion criteria provided
1012355	NM_001267550.2(TTN):c.54809del (p.Ile18270fs)	TTN-AS1	Pathogenic	no assertion criteria provided
1030165	NM_001267550.2(TTN):c.91920G>A (p.Trp30640Ter)	TTN-AS1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1061173	NM_001267550.2(TTN):c.46603C>T (p.Arg15535Ter)	TTN-AS1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1066067	NM_001267550.2(TTN):c.53206C>T (p.Arg17736Ter)	TTN-AS1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1067228	NM_001267550.2(TTN):c.95872C>T (p.Arg31958Ter)	TTN-AS1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1067472	NM_001267550.2(TTN):c.83971C>T (p.Gln27991Ter)	TTN-AS1	Pathogenic	criteria provided, multiple submitters, no conflicts
1068107	NM_001267550.2(TTN):c.47797A>T (p.Arg15933Ter)	TTN-AS1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts

Genes & proteins

Mendelian disease overlap and somatic drivers

GenCC: 21 · Orphanet: 32 · OMIM-shared: 0 · Dual-evidence (GWAS+Mendelian): 0

GenCC gene–disease validity (cohort genes)

the Disease column is the GenCC-asserted condition — a cohort gene’s strongest validity may be for a related predisposition syndrome.

Gene	Classification	Inheritance	Disease	Records
TTN	Definitive	Autosomal dominant	dilated cardiomyopathy 1G	21

Orphanet rare-disease linkage (cohort genes)

Gene	Orphanet ID	Rare disease
TTN	Orphanet:140922	Titin-related limb-girdle muscular dystrophy R10
TTN	Orphanet:154	Familial isolated dilated cardiomyopathy
TTN	Orphanet:169186	Autosomal recessive centronuclear myopathy
TTN	Orphanet:178464	Hereditary myopathy with early respiratory failure
TTN	Orphanet:289377	Early-onset myopathy with fatal cardiomyopathy
TTN	Orphanet:293888	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant
TTN	Orphanet:293899	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant
TTN	Orphanet:293910	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant
TTN	Orphanet:324604	Classic multiminicore myopathy
TTN	Orphanet:334	Hereditary atrial fibrillation
TTN	Orphanet:466921	Childhood-onset progressive contractures-limb-girdle weakness-muscle dystrophy syndrome
TTN	Orphanet:609	Tibial muscular dystrophy
TTN	Orphanet:707983	Early-onset autosomal recessive TTN-related distal myopathy
CORIN	Orphanet:275555	Preeclampsia
CCDC141	Orphanet:478	Kallmann syndrome
DSP	Orphanet:154	Familial isolated dilated cardiomyopathy
DSP	Orphanet:158687	Lethal acantholytic erosive disorder
DSP	Orphanet:2032	Idiopathic pulmonary fibrosis
DSP	Orphanet:293165	Skin fragility-woolly hair-palmoplantar keratoderma syndrome
DSP	Orphanet:293888	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant
DSP	Orphanet:293899	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant
DSP	Orphanet:293910	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant
DSP	Orphanet:369992	Severe dermatitis-multiple allergies-metabolic wasting syndrome
DSP	Orphanet:476096	Erythrokeratodermia-cardiomyopathy syndrome
DSP	Orphanet:50942	Striate palmoplantar keratoderma
DSP	Orphanet:65282	Carvajal syndrome
LRP4	Orphanet:3152	Sclerosteosis
LRP4	Orphanet:3258	Cenani-Lenz syndrome
LRP4	Orphanet:98913	Postsynaptic congenital myasthenic syndrome
PMS2	Orphanet:144	Lynch syndrome
PMS2	Orphanet:252202	Constitutional mismatch repair deficiency syndrome
PRKRA	Orphanet:210571	Dystonia 16

Cohort genes → proteins

11 cohort genes, 9 distinct canonical proteins.

Evidence partition

Subset	Genes
multi_evidence	11

Cohort genes (full)

Symbol	HGNC	Ensembl	UniProt	Name	Evidence
TTN	HGNC:12403	ENSG00000155657	Q8WZ42	Titin	gencc,clinvar
PLEKHA3	HGNC:14338	ENSG00000116095	Q9HB20	Pleckstrin homology domain-containing family A member 3	clinvar
CORIN	HGNC:19012	ENSG00000145244	Q9Y5Q5	Atrial natriuretic peptide-converting enzyme	clinvar
CCDC141	HGNC:26821	ENSG00000163492	Q6ZP82	Coiled-coil domain-containing protein 141	clinvar
DSP	HGNC:3052	ENSG00000096696	P15924	Desmoplakin	clinvar
FKBP7	HGNC:3723	ENSG00000079150	Q9Y680	Peptidyl-prolyl cis-trans isomerase FKBP7	clinvar
TTN-AS1	HGNC:44124	ENSG00000237298		TTN antisense RNA 1	clinvar
CYLD-AS1	HGNC:55352	ENSG00000261644		CYLD antisense RNA 1	clinvar
LRP4	HGNC:6696	ENSG00000134569	O75096	Low-density lipoprotein receptor-related protein 4	clinvar
PMS2	HGNC:9122	ENSG00000122512	P54278	Mismatch repair endonuclease PMS2	clinvar
PRKRA	HGNC:9438	ENSG00000180228	O75569	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	clinvar

Cohort function summary

Lead sentence per gene, UniProt-curated.

Symbol	Protein name	Function (lead sentence)
TTN	Titin	Key component in the assembly and functioning of vertebrate striated muscles.
PLEKHA3	Pleckstrin homology domain-containing family A member 3	Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane.
CORIN	Atrial natriuretic peptide-converting enzyme	Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing.
CCDC141	Coiled-coil domain-containing protein 141	Plays a critical role in cortical radial and GnRH neurons migration during brain development.
DSP	Desmoplakin	A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion.
FKBP7	Peptidyl-prolyl cis-trans isomerase FKBP7	PPIases accelerate the folding of proteins during protein synthesis.
LRP4	Low-density lipoprotein receptor-related protein 4	Mediates SOST-dependent inhibition of bone formation.
PMS2	Mismatch repair endonuclease PMS2	Component of the post-replicative DNA mismatch repair system (MMR).
PRKRA	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis.

Protein-family classification

Druggable: 3 · Difficult: 2 · Unknown: 6 · Druggable fraction: 0.27

Family distribution

Cohort families vs a genome-wide background (hypergeometric, BH-FDR; fold = observed/expected). Counts kept; sorted by enrichment, so the catch-all Other/Unknown bucket no longer leads.

Family	Genes	Fold	FDR
Protease	1	3.3×	0.416
Scaffold/PPI	2	3.1×	0.416
Antibody/Immunoglobulin	1	2.6×	0.416
Kinase	1	2.5×	0.416
Other/Unknown	6	1.0×	0.654

Per-gene assignment

Symbol	Family	Druggable?	EC	InterPro (top 3)
TTN	Kinase	yes	2.7.11.1	Prot_kinase_dom, Ig_sub2, Ig_sub
PLEKHA3	Scaffold/PPI	no		PH_domain, PH-like_dom_sf, Boi1/Boi2-like
CORIN	Protease	yes		SRCR, Trypsin_dom, LDrepeatLR_classA_rpt
CCDC141	Antibody/Immunoglobulin	yes		Spectrin_repeat, Ig_sub2, Ig_sub
DSP	Scaffold/PPI	no		Plectin_repeat, SH3_domain, Spectrin/alpha-actinin
FKBP7	Other/Unknown	no		PPIase_FKBP_dom, EF_hand_dom, EF-hand-dom_pair
TTN-AS1	Other/Unknown	no
CYLD-AS1	Other/Unknown	no
LRP4	Other/Unknown	no		LDLR_classB_rpt, EGF, EGF-like_Ca-bd_dom
PMS2	Other/Unknown	no		MutL/Mlh/PMS, DNA_mismatch_S5_2-like, Ribsml_uS5_D2-typ_fold_subgr
PRKRA	Other/Unknown	no		dsRBD_dom, PRKRA_DSRM_1, PRKRA_DSRM_2

Expression context

Cohort genes with no expression data: 0.

10 cohort genes are a single-cell marker in ≥1 SCXA experiment.

Breadth distribution (Bgee present_calls)

Bucket	Genes
narrow (1-5 tissues)	0
moderate (6-20)	0
broad (>20)	11
unknown	0

Top tissues across cohort

Tissue	Cohort genes
biceps brachii	2
skeletal muscle tissue of biceps brachii	2
right atrium auricular region	2
gluteal muscle	1
endothelial cell	1
epithelial cell of pancreas	1
oviduct epithelium	1
cardiac muscle of right atrium	1
heart right ventricle	1
myocardium	1
adrenal tissue	1
heart left ventricle	1
hair follicle	1
skin of hip	1
upper leg skin	1
calcaneal tendon	1
left ovary	1
stromal cell of endometrium	1
gastrocnemius	1
hindlimb stylopod muscle	1

Per-gene tissue summary (top 30)

Symbol	Bgee breadth	FANTOM5 breadth	SCXA	Top tissues
TTN	223	broad	marker	biceps brachii, gluteal muscle, skeletal muscle tissue of biceps brachii
PLEKHA3	259	ubiquitous	marker	epithelial cell of pancreas, oviduct epithelium, endothelial cell
CORIN	176	tissue_specific	marker	cardiac muscle of right atrium, heart right ventricle, myocardium
CCDC141	149	broad	marker	heart left ventricle, adrenal tissue, right atrium auricular region
DSP	253	ubiquitous	marker	skin of hip, upper leg skin, hair follicle
FKBP7	230	ubiquitous	marker	stromal cell of endometrium, calcaneal tendon, left ovary
TTN-AS1	174	ubiquitous	marker	hindlimb stylopod muscle, gastrocnemius, right atrium auricular region
CYLD-AS1	126		yes	granulocyte, monocyte, leukocyte
LRP4	242	ubiquitous	marker	ventricular zone, dorsal motor nucleus of vagus nerve, medial globus pallidus
PMS2	143	ubiquitous	marker	thymus, prefrontal cortex, male germ line stem cell (sensu Vertebrata) in testis
PRKRA	294	ubiquitous	marker	sperm, skeletal muscle tissue of biceps brachii, biceps brachii

Protein interactions among cohort

Intra-cohort edges: 1.

Hub genes (top 10 by interactor count)

Symbol	Interactor count
TTN	4,237
DSP	2,897
PMS2	2,658
PRKRA	2,410
FKBP7	2,058
CORIN	1,291
CCDC141	1,255
LRP4	1,250
PLEKHA3	810
TTN-AS1	0

Intra-cohort edges

A	B	Sources
FKBP7	PLEKHA3	string_interaction

Structural data

PDB: 6 · AlphaFold-only: 3 · No structure: 2

Cohort genes with PDB structures (top 30)

Symbol	UniProt	PDB entries
TTN	Q8WZ42	64
PMS2	P54278	9
DSP	P15924	4
PLEKHA3	Q9HB20	3
PRKRA	O75569	2
LRP4	O75096	1

AlphaFold-only cohort genes (top 30 by pLDDT)

Symbol	UniProt	pLDDT
FKBP7	Q9Y680	86.12
CCDC141	Q6ZP82	72.36
CORIN	Q9Y5Q5	70.20

Function

Pathway analysis

Distinct Reactome pathways touched by cohort: 20. Enrichment computed across 11 evidence-associated genes (7 with Reactome annotation).

Pathways by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 7 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

Pathway	Cohort genes	Fold	FDR	Sample cohort genes
Defective Mismatch Repair Associated With MLH1	1	815.7×	0.012	PMS2
Defective Mismatch Repair Associated With PMS2	1	815.7×	0.012	PMS2
Small interfering RNA (siRNA) biogenesis	1	163.1×	0.029	PRKRA
Apoptotic cleavage of cell adhesion proteins	1	148.3×	0.029	DSP
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	1	116.5×	0.029	PMS2
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	1	116.5×	0.029	PMS2
Physiological factors	1	96.0×	0.030	CORIN
MicroRNA (miRNA) biogenesis	1	65.3×	0.038	PRKRA
Striated Muscle Contraction	1	44.1×	0.048	TTN
RND1 GTPase cycle	1	37.9×	0.048	DSP
RND3 GTPase cycle	1	37.1×	0.048	DSP
Synthesis of PIPs at the plasma membrane	1	30.2×	0.054	PLEKHA3
TP53 Regulates Transcription of DNA Repair Genes	1	25.9×	0.058	PMS2
ECM proteoglycans	1	21.5×	0.065	LRP4
PKR-mediated signaling	1	20.1×	0.065	PRKRA
Platelet degranulation	1	12.6×	0.091	TTN
Formation of the cornified envelope	1	12.6×	0.091	DSP
Extracellular matrix organization	1	9.0×	0.118	LRP4
Keratinization	1	8.0×	0.125	DSP
Neutrophil degranulation	1	3.3×	0.267	DSP

GO biological processes by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 8 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

GO term	Cohort genes	Fold	FDR	Sample cohort genes
positive regulation of presynaptic membrane organization	1	2106.5×	0.016	LRP4
regulation of systemic arterial blood pressure by atrial natriuretic peptide	1	702.2×	0.016	CORIN
skeletal muscle myosin thick filament assembly	1	702.2×	0.016	TTN
sarcomerogenesis	1	702.2×	0.016	TTN
synaptic assembly at neuromuscular junction	1	702.2×	0.016	LRP4
regulation of regulatory ncRNA processing	1	702.2×	0.016	PRKRA
somatic recombination of immunoglobulin gene segments	1	526.6×	0.016	PMS2
regulation of renal sodium excretion	1	526.6×	0.016	CORIN
skeletal muscle thin filament assembly	1	351.1×	0.016	TTN
positive regulation of isotype switching to IgA isotypes	1	351.1×	0.016	PMS2
ventricular compact myocardium morphogenesis	1	300.9×	0.016	DSP
detection of muscle stretch	1	300.9×	0.016	TTN
bundle of His cell-Purkinje myocyte adhesion involved in cell communication	1	300.9×	0.016	DSP
postsynaptic membrane assembly	1	300.9×	0.016	LRP4
desmosome organization	1	263.3×	0.016	DSP
amyloid-beta clearance by cellular catabolic process	1	263.3×	0.016	LRP4
siRNA processing	1	234.1×	0.016	PRKRA
skeletal muscle acetylcholine-gated channel clustering	1	234.1×	0.016	LRP4
protein localization to cell-cell junction	1	234.1×	0.016	DSP
positive regulation of skeletal muscle acetylcholine-gated channel clustering	1	234.1×	0.016	LRP4
cardiac muscle hypertrophy	1	210.7×	0.016	TTN
cerebral cortex radially oriented cell migration	1	210.7×	0.016	CCDC141
presynaptic membrane assembly	1	210.7×	0.016	LRP4
outer ear morphogenesis	1	191.5×	0.016	PRKRA
positive regulation of isotype switching to IgG isotypes	1	191.5×	0.016	PMS2
generation of neurons	1	191.5×	0.016	LRP4
RISC complex assembly	1	191.5×	0.016	PRKRA
obsolete protein kinase A signaling	1	175.5×	0.016	TTN
peptide cross-linking	1	175.5×	0.016	DSP
cardiac muscle tissue morphogenesis	1	175.5×	0.016	TTN

Therapeutics

Drug target analysis

Approved (phase 4): 0 · Phase ≥3: 0 · Phased (≥1): 0 · Undrugged: 11

Druggability breadth: 3 of 11 evidence-associated genes (27%) have a ChEMBL target (buckets above are over the deeply-mined display cohort).

Top cohort targets by molecule count

Symbol	Molecules	Max phase
TTN	0	0
PLEKHA3	0	0
CORIN	0	0
CCDC141	0	0
DSP	0	0
FKBP7	0	0
TTN-AS1	0	0
CYLD-AS1	0	0
LRP4	0	0
PMS2	0	0

Bioactivity and enzyme data

Enzyme cohort genes (≥1 EC): 1.

Cohort genes with ChEMBL bioactivity (full, sorted by assay count)

Symbol	Assays	Type breakdown
DSP	2	Binding:2
TTN	1	Binding:1
PMS2	1	Binding:1

Cohort enzymes (BRENDA EC)

Symbol	EC numbers	Names
TTN	2.7.11.1	non-specific serine/threonine protein kinase

Pharmacogenomics

Cohort genes with a PharmGKB record: 9; with CPIC/DPWG dosing guidelines: 0.

No cohort gene has a CPIC/DPWG genotype-guided dosing guideline (PharmGKB).

Chemical tractability of cohort targets

0 approved/phased compounds have measured bioactivity against a cohort gene (and aren’t yet in disease-level trials). This is a research / tractability signal, NOT a therapeutic recommendation — a bioactivity row often reflects off-target or screening binding (e.g. promiscuous kinase inhibitors against a cohort kinase), implying no disease mechanism.

Druggability pyramid

Cohort genes binned by druggability tier (high → low):

Tier	Definition	Genes	Symbols
A	Approved (phase 4 drug)	0
B	Phased (≥1) drug, not yet approved	0
C	Druggable family + PDB, no drug	1	TTN
D	Druggable family + AlphaFold only, no drug	2	CORIN, CCDC141
E	Difficult family or no structure, no drug	8	PLEKHA3, DSP, FKBP7, TTN-AS1, CYLD-AS1, LRP4, PMS2, PRKRA

Undrugged target profiles

11 cohort genes are undrugged. Ranked by ‘starting-point quality’ (assay depth + drugged-partner adjacency).

Symbol	ChEMBL assays	Drugged partners (top 3)
TTN	1	—
PLEKHA3	0	—
CORIN	0	—
CCDC141	0	—
DSP	2	—
FKBP7	0	—
TTN-AS1	0	—
CYLD-AS1	0	—
LRP4	0	—
PMS2	1	—
PRKRA	0	—

Clinical trials & evidence

Clinical trials

Clinical trials: 0.