Drug-induced methemoglobinemia

Summary

Drug-induced methemoglobinemia (MONDO:0018740) is a disease. A subtype of methemoglobinemia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 21

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		242	Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

21 HPO clinical features (Orphanet curated; top 21 by frequency):

HPO ID	Term	Frequency
HP:0012119	Methemoglobinemia	Very frequent (80-99%)
HP:0000739	Anxiety	Frequent (30-79%)
HP:0000961	Cyanosis	Frequent (30-79%)
HP:0001289	Confusion	Frequent (30-79%)
HP:0001941	Acidosis	Frequent (30-79%)
HP:0001962	Palpitations	Frequent (30-79%)
HP:0002013	Vomiting	Frequent (30-79%)
HP:0002094	Dyspnea	Frequent (30-79%)
HP:0002315	Headache	Frequent (30-79%)
HP:0002321	Vertigo	Frequent (30-79%)
HP:0012378	Fatigue	Frequent (30-79%)
HP:0012418	Hypoxemia	Frequent (30-79%)
HP:0001259	Coma	Occasional (5-29%)
HP:0001279	Syncope	Occasional (5-29%)
HP:0001649	Tachycardia	Occasional (5-29%)
HP:0002027	Abdominal pain	Occasional (5-29%)
HP:0002329	Drowsiness	Occasional (5-29%)
HP:0007185	Loss of consciousness	Occasional (5-29%)
HP:0011675	Arrhythmia	Occasional (5-29%)
HP:0001250	Seizure	Very rare (<1-4%)
HP:0002098	Respiratory distress	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	drug-induced methemoglobinemia
Mondo ID	MONDO:0018740
Orphanet	464453
ICD-11	746336827
NCIT	C101045
SNOMED CT	191390009
UMLS	C0472781
MedGen	632786
GARD	0021930
Is cancer (heuristic)	no

Also known as: acquired methemoglobinemia · drug induced methemoglobinemia

Disease family

This is a subtype of methemoglobinemia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › hematologic disorder › erythrocyte disorder › hemoglobinopathy › methemoglobinemia › drug-induced methemoglobinemia

Related subtypes (1): hereditary methemoglobinemia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.