Ductal breast carcinoma in situ and lobular carcinoma in situ

Summary

Ductal breast carcinoma in situ and lobular carcinoma in situ (MONDO:0006184) is a cancer and 1 clinical trial. A subtype of breast carcinoma in situ — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	ductal breast carcinoma in situ and lobular carcinoma in situ
Mondo ID	MONDO:0006184
EFO	EFO:1000221
NCIT	C4195
UMLS	C0334383
MedGen	83137
Is cancer (heuristic)	yes

Also known as: DCIS and LCIS of breast · DCIS and LCIS of the breast · ductal and lobular breast carcinoma in situ · ductal and lobular carcinoma in situ of breast · ductal and lobular carcinoma in situ of the breast · ductal carcinoma in situ with lobular carcinoma in situ of breast · ductal carcinoma in situ with lobular carcinoma in situ of the breast · intraductal and lobular breast carcinoma in situ · intraductal and lobular carcinoma in situ of breast · intraductal and lobular carcinoma in situ of the breast · intraductal carcinoma and lobular carcinoma in situ · non-infiltrating ductal and non-infiltrating lobular breast carcinoma · non-infiltrating ductal with non-infiltrating lobular carcinoma of breast · non-infiltrating ductal with non-infiltrating lobular carcinoma of the breast · non-invasive ductal and non-invasive lobular breast carcinoma · non-invasive ductal and non-invasive lobular carcinoma · non-invasive ductal breast carcinoma with non-invasive lobular breast carcinoma · non-invasive ductal carcinoma with non-invasive lobular carcinoma of breast · non-invasive ductal carcinoma with non-invasive lobular carcinoma of the breast · non-invasive ductal with non-invasive lobular breast carcinoma

Disease family

This is a subtype of breast carcinoma in situ. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › carcinoma › in situ carcinoma › breast carcinoma in situ › ductal breast carcinoma in situ and lobular carcinoma in situ

Related subtypes (3): lobular neoplasia, breast apocrine carcinoma in situ, ductal breast carcinoma in situ

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01841749	Not specified	COMPLETED	Management of Ductal Carcinoma in Situ or Pure Micro-invasive Extended Breast