Dysautonomia
diseaseOn this page
Summary
Dysautonomia (MONDO:0044872) is a disease and 30 clinical trials. Top therapeutic interventions include pyridostigmine, baclofen, and esmolol. A subtype of autonomic nervous system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- ClinVar variants: 1
- Clinical trials: 30
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | dysautonomia |
| Mondo ID | MONDO:0044872 |
| NCIT | C53439 |
| UMLS | C0013363 |
| MedGen | 8511 |
| Is cancer (heuristic) | no |
Also known as: dysautonomia
Data availability: 1 ClinVar variant.
Disease family
This is a subtype of autonomic nervous system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › autonomic nervous system disorder › dysautonomia
Related subtypes (12): idiopathic peripheral autonomic neuropathy, autonomic neuropathy, autonomic nervous system neoplasm, Frey syndrome, harlequin syndrome, chronic hiccup, pure autonomic failure, baroreflex failure, autonomic dysreflexia, sympathetic nervous system disorder, parasympathetic nervous system disorder, central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease
Subtypes (1): primary dysautonomia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
ClinVar germline variants
1 retrieved; paginated sample, class counts are floors:
1 uncertain significance
| ClinVar | Variant (HGVS) | Gene | Classification | Review |
|---|---|---|---|---|
| 267889 | 46;XX;inv(14)(q24.1q32.1)dn | Uncertain significance | criteria provided, single submitter |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 30.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 24 |
| PHASE2 | 3 |
| PHASE1 | 2 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06073886 | PHASE2 | RECRUITING | Personalized Brain Stimulation to Treat Chronic Concussive Symptoms |
| NCT00221689 | PHASE2 | TERMINATED | Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients |
| NCT01343329 | PHASE1/PHASE2 | WITHDRAWN | Controlling Hyperadrenergic Activity in Neurologic Injury |
| NCT03674541 | PHASE2 | COMPLETED | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome |
| NCT04121338 | PHASE1 | COMPLETED | Temporary Celiac Ganglion Block as a Test Before Celiac Ganglion Resection for Dysautonomia-Related Bowel Dysmotility |
| NCT05638620 | PHASE1 | COMPLETED | Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Long COVID |
| NCT04806620 | Not specified | RECRUITING | Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research |
| NCT05041387 | Not specified | RECRUITING | Data Collection of Standard Care of Patients in the EMG Section |
| NCT05400174 | Not specified | RECRUITING | Blood Pressure Effects on Cognition and Brain Blood Flow in PD |
| NCT05741112 | Not specified | RECRUITING | The Long COVID-19 Wearable Device Study |
| NCT06554834 | Not specified | RECRUITING | Effects of Osteopathic Technique on Autonomic Nervous System Activity |
| NCT06863207 | Not specified | RECRUITING | Autonomic Reactivity and Personalized Neurostimulation |
| NCT07405515 | Not specified | ACTIVE_NOT_RECRUITING | Pathophysiology of Dysautonomia and Postural Tachycardia Syndrome (POTS) in Post-viral Syndromes and COVID-19 |
| NCT07409363 | Not specified | NOT_YET_RECRUITING | Non-invasive Vagus Nerve Stimulation for Chronic Musculoskeletal Pain |
| NCT07481292 | Not specified | ENROLLING_BY_INVITATION | Neuro-Emotional Release: Veins and Endocrine System (NERVE) Therapy for Children With Dysautonomia |
| NCT00565526 | Not specified | COMPLETED | Evaluation of the Role of the Autonomic Nervous System in Sj(SqrRoot)(Delta)Gren s Syndrome |
| NCT01367977 | Not specified | COMPLETED | Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life |
| NCT01692561 | Not specified | COMPLETED | MRI to Assess the Effects of Dysautonomia and Chronic Nausea on Brain Transmitters |
| NCT02931773 | Not specified | UNKNOWN | Autonomic Cardiovascular Neuropathy in Recently Diagnosed DM2 Patients (ACNDM2) |
| NCT03185247 | Not specified | COMPLETED | Implementation of Transdx Group for POTS |
| NCT03681080 | Not specified | COMPLETED | Concentration and Attentional Deficits in POTS and Other Autonomic Neuropathies |
| NCT04502199 | Not specified | UNKNOWN | Dysautonomic Phenotype in Male Patients With MECP2 Mutation |
| NCT05515640 | Not specified | UNKNOWN | Dysautonomia and Systemic Interactions in Traumatic Brain Injury |
| NCT05566379 | Not specified | COMPLETED | Mindfulness in Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia |
| NCT05630040 | Not specified | COMPLETED | VNS for Long-COVID-19 |
| NCT05681455 | Not specified | UNKNOWN | Physiotherapy for Persistent Function by Superficial Neuromodulation |
| NCT05812209 | Not specified | COMPLETED | Stellate Ganglion Block to Treat Long COVID 19 Case Series |
| NCT05855356 | Not specified | UNKNOWN | Post Covid-19 Dysautonomia Rehabilitation Randomized Controlled Trial |
| NCT07029191 | Not specified | COMPLETED | Screening for Alterations in the Autonomic Nervous System |
| NCT07255573 | Not specified | COMPLETED | Diagnostic Accuracy of The Water Immersion Wrinkle Test for Small Fiber Neuropathy |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PYRIDOSTIGMINE | 4 | 2 |
| BACLOFEN | 4 | 1 |
| ESMOLOL | 4 | 1 |
| PROPRANOLOL | 4 | 1 |
Related Atlas pages
- Drugs: Pyridostigmine, Baclofen, Esmolol, Propranolol