Dyscalculia

Summary

Dyscalculia (MONDO:0001552) is a disease and 3 clinical trials. A subtype of learning disability — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• ClinVar variants: 2
• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	dyscalculia
Mondo ID	MONDO:0001552
MeSH	D060705
DOID	DOID:12568
ICD-10-CM	F81.2
ICD-11	308101648
NCIT	C97165
SNOMED CT	47916000
UMLS	C0869474
MedGen	452779
Is cancer (heuristic)	no

Also known as: dyscalculia · dyscalculia (disease) · mathematics disorder

Data availability: 2 ClinVar variants · 1 HPO phenotype.

Disease family

This is a subtype of learning disability. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › mental disorder › developmental disorder of mental health › specific developmental disorder › learning disability › dyscalculia

Related subtypes (2): writing disorder, reading disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

ClinVar germline variants

2 retrieved; paginated sample, class counts are floors:

1 likely pathogenic, 1 pathogenic

ClinVar	Variant (HGVS)	Gene	Classification	Review
268035	46;XX;t(19;21)(q13.3;q22.3)dn		Pathogenic	criteria provided, single submitter
267898	46;XY;inv(7)(p15q34)mat		Likely pathogenic	criteria provided, single submitter

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05201534	Not specified	RECRUITING	Interventions in Mathematics and Cognitive Skills
NCT03354481	Not specified	COMPLETED	Automatization of Counting Procedures in Children With Dyscalculia
NCT05709418	Not specified	UNKNOWN	Intervention for Low-performing First Graders in Mathematics