Dyskinesia of esophagus

Summary

Dyskinesia of esophagus (MONDO:0004729) is a disease and 26 clinical trials. Top therapeutic interventions include prucalopride, codeine phosphate, and famotidine. A subtype of esophageal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 26

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	dyskinesia of esophagus
Mondo ID	MONDO:0004729
MeSH	D015154
DOID	DOID:9192
ICD-10-CM	K22.4
ICD-11	581725607
SNOMED CT	266434009
UMLS	C0014858
MedGen	41868
Is cancer (heuristic)	no

Also known as: dyskinesia of esophagus · esophageal motility disorder · oesophageal dysmotility · oesophageal motor disorder

Disease family

This is a subtype of esophageal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › upper digestive tract disorder › esophageal disorder › dyskinesia of esophagus

Related subtypes (19): esophageal atresia, esophageal varices, esophagitis, megaesophagus, esophageal tuberculosis, esophageal leukoplakia, esophageal diverticulosis, gastroesophageal reflux disease, esophageal atresia/tracheoesophageal fistula, achalasia, Barrett esophagus, esophageal duplication cyst, tubular duplication of the esophagus, laryngotracheoesophageal cleft, isolated tracheo-esophageal fistula, congenital esophageal diverticulum, neoplasm of esophagus, esophageal ulcer, congenital esophageal stenosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 26.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	20
PHASE4	3
PHASE2	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05455359	PHASE4	RECRUITING	Gastrointestinal Dysmotility on Aspiration Risk
NCT02736734	PHASE4	COMPLETED	The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy Volunteers
NCT03784105	PHASE4	COMPLETED	Codeine on Pharyngeal and Esophageal Motility
NCT01302301	PHASE2	UNKNOWN	Endolumenal Partial Myotomy for Esophageal Motility Disorders
NCT01448993	PHASE2	COMPLETED	Effect of Azithromycin on Oesophageal Hypomotility
NCT05604261	PHASE2	UNKNOWN	A Study of Anaprazole Sodium Enteric-coated Tablets in the Treatment of Reflux Esophagitis
NCT05132816	Not specified	RECRUITING	High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux
NCT05272046	Not specified	ACTIVE_NOT_RECRUITING	Monopolar and Bipolar Current RFA Knife in POEM
NCT05380791	Not specified	RECRUITING	Effect of Esophageal Contractile Reserve on Changes in Esophageal Motility and Symptoms After ARS in Patients With GERD
NCT06878586	Not specified	NOT_YET_RECRUITING	Diagnostic Evaluation of Esophageal Motility Disorders Using the Chicago IV Protocol in Egypt
NCT07496840	Not specified	RECRUITING	Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM)
NCT01234428	Not specified	COMPLETED	Esophageal Dysmotility and Dilatation After Laparoscopic Gastric Banding
NCT01447823	Not specified	UNKNOWN	Observational Field Study of Acute Esophageal Food Bolus Impaction by Mean Esophageal Manometry and 24h-pH-monitoring
NCT01658865	Not specified	UNKNOWN	Assessment of Esophageal Motility With Transnasal Endoscopy
NCT02663206	Not specified	WITHDRAWN	Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in Spastic Esophageal Disorders
NCT03012854	Not specified	UNKNOWN	Different Surgical Procedures of Peroral Endoscopic Myotomy(POEM) for Esophageal Achalasia
NCT03100357	Not specified	UNKNOWN	Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery
NCT03347903	Not specified	COMPLETED	Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease
NCT03662490	Not specified	UNKNOWN	Correlation Between Clinical Signs and High-resolution Manometry Data in Children
NCT03904004	Not specified	UNKNOWN	Pressure and Flow Study Before and After Treatments for EMD. The pFlow Study
NCT05402462	Not specified	UNKNOWN	Esophageal Motility Disorders in Patients With Non-cardiac Chest Pain at Assiut University Hospital
NCT05913011	Not specified	UNKNOWN	Prevalence of IEM Among Upper GIT Symptoms
NCT06314893	Not specified	TERMINATED	Establishing a Correlation Between HRM and UGI MM Studies
NCT06329583	Not specified	COMPLETED	Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry
NCT06629025	Not specified	COMPLETED	The Clinical Manifestation and Prognosis of Pediatric Esophageal Motility Disorders
NCT06918730	Not specified	COMPLETED	U-POEM vs CO2-POEM

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PRUCALOPRIDE	4	2
CODEINE PHOSPHATE	4	1
FAMOTIDINE	4	1
RABEPRAZOLE	4	1
ANAPRAZOLE	3	1
CHEMBL4747028	0	1