Dystocia

Summary

Dystocia (MONDO:0006737) is a disease and 12 clinical trials. Top therapeutic interventions include oxytocin. A subtype of pregnancy disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 12

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	dystocia
Mondo ID	MONDO:0006737
EFO	EFO:1000911
MeSH	D004420
UMLS	C0013418
MedGen	3939
Is cancer (heuristic)	no

Disease family

This is a subtype of pregnancy disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › obstetric disorder › pregnancy disorder › dystocia

Related subtypes (28): funisitis, chorea gravidarum, luteoma of pregnancy, polyhydramnios, impetigo herpetiformis, gestational diabetes, placenta disorder, pemphigoid gestationis, hyperemesis gravidarum, pruritic urticarial papules and plaques of pregnancy, familial gestational hyperthyroidism, pseudohyperaldosteronism type 2, aromatase deficiency, acute fatty liver of pregnancy, malignancy diagnosed during pregnancy, postpartum psychosis, peripartum cardiomyopathy, gestational trophoblastic neoplasm, hypertension, pregnancy-induced, chronic intervillositis of unknown etiology, pregnancy disorder with abortive outcome, postpartum amenorrhea-galactorrhea syndrome, pregnancy associated osteoporosis, twin anemia-polycythemia sequence, twin-reversed arterial perfusion sequence, selective intrauterine growth restriction, amniotic fluid embolism, vasa previa

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Oxytocin	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Propranolol.

Clinical trials & evidence

Clinical trials

Clinical trials: 12.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE4	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02487797	PHASE4	COMPLETED	Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation
NCT00279071	PHASE2	TERMINATED	Use of Acupuncture for Stimulation of Labour
NCT02643108	Not specified	ACTIVE_NOT_RECRUITING	Lateral Episiotomy or Not in Vacuum Assisted Delivery in Non-parous Women
NCT01107158	Not specified	TERMINATED	LXRs, Cholesterol Metabolism and Uterine Dystocia
NCT01291355	Not specified	COMPLETED	Maternal Positioning and Occipitoposterior Fetal Position
NCT01530113	Not specified	UNKNOWN	Childhood Sexual Abuse, Vaginismus and Labor Dystocia
NCT02486822	Not specified	UNKNOWN	Labor Scale Versus WHO Partograph in the Management of Labor
NCT02741141	Not specified	TERMINATED	A Comparative Study of the Effect of Two Partographs on the Cesarean Section Rate in Women in Spontaneous Labour
NCT02934516	Not specified	UNKNOWN	Push With Lower Uterine Segment Support
NCT02941393	Not specified	COMPLETED	Internal Versus External Tocodynamometry and Labor Outcome
NCT04649593	Not specified	COMPLETED	The Study of Giving Birth, a Study About Treatment of Labor Dystocia
NCT05341076	Not specified	UNKNOWN	Labor Scale Versus WHO Partograph for Management of Labor (ScaLP)

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
OXYTOCIN	4	3
CHEMBL4303358	0	1